Assistant Professor

Department of Physiology and Pharmacology

Schulich School of Medicine & Dentistry

The University of Western Ontario

Associate Scientist, Children’s Health Research Institute, Developmental Biology Program

and Lawson Health Research Institute

Email: cheryle.seguin@schulich.uwo.ca

 

Séguin Lab

Dr. Séguin obtained her BSc (1999) and MSc (2001) from The University of Western Ontario and her PhD in the area of cell biology and tissue engineering from the University of Toronto (2005).  Following this, Dr. Séguin became a postdoctoral fellow under the supervision of Dr. Janet Rossant at the SickKids Hospital, working in the field of early mammalian development and stem cell biology. While at SickKids Hospital, Dr. Séguin assumed the role of Interim Manager and helped establish the Ontario Human Induced Pluripotent Stem Cell (iPSC) Facility, an endeavour funded by the Ontario Ministry of Innovation and spearheaded by Drs. James Ellis and Bill Stanford. In 2009, Dr. Séguin was recruited to the Department of Physiology and Pharmacology at The University of Western.


Our research group is focused on unraveling the mechanisms of mammalian stem cell differentiation for potential regenerative medicine applications.


Using transgenic technologies and tissue engineering strategies, one research theme is focused on the development of combinatorial approaches to generate pancreas restricted progenitor cells and their subsequent maturation to functional insulin secreting beta-cells as a strategy for the reversal of diabetes. 


In a second research theme, novel tissue-specific Cre mouse models are being employed to examine cell fate determination and undertake a comprehensive analysis of the phenotype of the distinctive cells within the mammalian intervertebral disc.  The long term goal of these studies is the development of bioengineering strategies to exploit the role of tissue specific stem cells for cell-based strategies for spine and skeletal tissue regenerative medicine.