These notes and papers are password protected, are in .pdf format and are for the personal use of UWO students enrolled in Biochemistry 4450A.  Other reproduction of lecture notes is not permitted without permission from Dr. Rodenhiser. Published papers are copyrighted by the publishers and are provided for personal use only.

Tentative 2009 lecture schedule: 4450Aschedule2009.pdf

Lecture Notes and Required Readings: 2009

Lectures, Dates and Titles                                                             Downloadable from WebCT

Lecture 1 (September 10)   ... Course Introduction                           4450A2009lecture1.pdf                       

Lecture 2 (September 15) ... Hallmarks of Cancer                            4450A2009lecture2.pdf ; Hanahan

Lecture 3 (September 17) ... Cancer Genes: Viral Oncs and Rb      notes 03 ;  Sherr  

Lecture 4 (September 22) ... Cancer Genes: ras and p53                notes 04 ;  Downward ; ElDeiry  

Lecture 5 (September 24) ... Multistage Progression / 2 hit              notes 05 ;  Knudson ; Pane ; Hahn  

Lecture 6 (September 29) ... Genomic Instability                              notes 06 ;  Fodde ; Lengauer  

Lecture 7 (October 1) ... Immortality and Senescence                      notes 07 ; Masutomi ; Narita  

Lecture 8 (October 6) ... Model Organisms                                       notes 08 ; Hariharan ; Vandyke  

IN CLASS QUIZ ... OCTOBER 8  

Lecture 9 (October 13)   ... Genomic Integrity: Apoptosis                  notes 09 ; Igney ; Cory    

Lecture 10 (October 15) ... DNA repair overview                               notes 10 ; Bernstein

Lecture 11 (October 20) ... Nucleotide Excision repair                      notes 11 ; Costa ; Freidberg

Lecture 12 (October 22) ... Colon Cancer                                         notes 12 ; Chung ; Narayan  

Lecture 13 (October 27) ... Breast Cancer and BRCA genes           notes 13 ; Narod            

IN CLASS REVIEW (optional) ... OCTOBER 29

MIDTERM ... TENTATIVE Date: THURSDAY, OCTOBER 29 at 7 pm

Lecture 14 (November 1)  ... Genes / environment                           notes 14 ; Montesano  

Lecture 15 (November 5) ... Epigenetics and Cancer                       notes 15 ; Rodenhiser ; Esteller

Lecture 16 (November 10) ... Metastasis and Angiogenesis            notes 16 ; Chambers ; Bergers ; Ellis figures

Lecture 17 (November 12) ... Pharmacogenomics                           notes 17 ; Ulrich          

Lecture 18 (November 17) ... Molecular Diagnostics                        notes 18 ; Olopade           

Lecture 19 (November 19) ... Molecular profiling: arrays                  notes 19  ; Russo ; Simon  

Lecture 20 (November 24) ... Therapies: Antisense                         notes 20 ; Gleave ; Rayburn   

Lecture 21 (November 26) ... Therapies: Viral approaches              notes 21 ; Bell ; Guo (background only)

Lecture 22 (December 1) ... Reovirus                                               notes 22 ; Everts ; Hirasawa    

Lecture 23 (December 3) ... Summing up, Review, Feedback         Summary

     

biochemistry 4450a

The Molecular Genetics of Human Cancer

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Lecture Notes and Required Readings will be accessible from WebCT