ÿþ<html> <meta http-equiv="content-type" content="text/html;charset=ISO-8859-1"> <head> <title>E.R.GILLIES-LAGUGNE-LABARTHET research homepage</title> <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1"> <SCRIPT language=JavaScript> button_home= new Image();button_home.src = "home.jpg"; button_home_b=new Image();button_home_b.src = "homeb.jpg"; button_members=new Image();button_members.src= "staff.jpg"; button_members_b=new Image();button_members_b.src = "staffb.jpg"; button_research=new Image();button_research.src="research.jpg"; button_research_b=new Image();button_research_b.src="researchb.jpg"; button_publications=new Image();button_publications.src= "publications.jpg"; button_publications_b=new Image();button_publications_b.src = "publicationsb.jpg"; button_positions=new Image();button_positions.src= "positions.jpg"; button_positions_b=new Image();button_positions_b.src = "positionsb.jpg"; button_teaching=new Image();button_teaching.src= "teaching.jpg"; button_teaching_b=new Image();button_teaching_b.src = "teachingb.jpg"; button_news=new Image();button_news.src= "news.jpg"; button_news_b=new Image();button_news_b.src = "newsb.jpg"; button_contactus=new Image();button_contactus.src= "contactus.jpg"; button_contactus_b=new Image();button_contactus_b.src = "contactusb.jpg"; function imageChange(imageID,imageName){document.images[imageID].src = eval(imageName + ".src");} </SCRIPT> </head> <body bgcolor="#FFFFFF"> <table width="900" height="460" border="0" align="center" cellpadding="0" cellspacing="0" id="main"> <tr align="left"> <td height="130" colspan="2"><div align="right"> <table width="900" height="130" border="0" cellpadding="0" cellspacing="0"> <tr> <td height="100"><img src="top1.jpg" width="100" height="100" border="0"></td> <td height="100"><img src="top2.jpg" width="100" height="100" border="0"></td> <td height="100"><img src="top4.jpg" width="100" height="100" border="0"></td> <td height="100"><img src="top3.jpg" width="100" height="100" border="0"></td> <td height="100"><img src="top5.jpg" width="100" height="100" border="0"></td> <td height="100"><img src="top6.jpg" width="100" height="100" border="0"></td> <td height="100"><a href="imag1.html"><img src="tower75.gif" width="100" height="100" border="0"></a></td> </a> </td> </tr> </table> </div> </td> </tr> <tr> <td width="200" align="left" valign="top" background="back.jpg"><table width="10" height="100" border="0" align="left" cellpadding="0" cellspacing="5"> </tr> <tr> <td width="190" ><a href="index.html" onMouseOver="imageChange('button_home1', 'button_home_b')" onMouseOut="imageChange('button_home1', 'button_home')"> <img src="home.jpg" width="190" name="button_home1" border="0"> </a> </td> </tr> <tr> <td height="20"><a href="staff.html" onMouseOver="imageChange('button_members1', 'button_members_b')" onMouseOut="imageChange('button_members1','button_members')"> <img src="staff.jpg" width="190" name="button_members1" border="0"> </a> </td> </tr> <tr> <td width="190" ><a href="research.html" onMouseOver="imageChange('button_research1', 'button_research_b')" onMouseOut="imageChange('button_research1', 'button_research')"> <img src="research.jpg" width="190" name="button_research1" border="0"> </a> </td> </tr> <tr> <td width="190" ><a href="publications.html" onMouseOver="imageChange('button_publications1', 'button_publications_b')" onMouseOut="imageChange('button_publications1','button_publications')"> <img src="publications.jpg" width="190" name="button_publications1" border="0"> </a> </td> </tr> <tr> <td width="190" > <a href="positions.html" onMouseOver="imageChange('button_positions1', 'button_positions_b')" onMouseOut="imageChange('button_positions1', 'button_positions')"> <img src="positions.jpg" width="190" name="button_positions1" border="0"> <tr> <td width="190"><a href="teaching.html" onMouseOver="imageChange('button_teaching1', 'button_teaching_b')" onMouseOut="imageChange('button_teaching1','button_teaching')"> <img src="teaching.jpg" width="190" name="button_teaching1" border="0"> </a> </td> </tr> <tr> <td width="190" > <a href="news.html" onMouseOver="imageChange('button_news1', 'button_news_b')" onMouseOut="imageChange('button_news1', 'button_news')"> <img src="news.jpg" width="190" name="button_news1" border="0"> </a> </td> </tr> <tr> <td width="190" > <a href="contactus.html" onMouseOver="imageChange('button_contactus1', 'button_contactus_b')" onMouseOut="imageChange('button_contactus1', 'button_contactus')"> <img src="contactus.jpg" width="190" name="button_contactus1" border="0"> </a> </td> </tr> </table> <td width="700" valign="top"><div align="left"> <h4 align="center"><font face="Arial, Helvetica, sans-serif"></p> <p align="left"> <h2><P align=left>Journal Articles</h2><br> <P align=left> <h2><P align=left>2012</h2><br> <P align=left> 39. Knight, D. K.; Stutchbury, R.; Imruck, D.; Halfpap, C.; Lin, S.; Langbein, U.; Gillies, E. R.; Mequanint, K.*  Focal Contact Formation of Vascular Smooth Muscle Cells on Langmuir-Blodgett and Solvent Cast Films of Poly(ester amide)s submitted <br><br> 38. Amos, R. C.; Bonduelle, C. V.; Nazemi, A.; Gillies, E. R.*  Tuning Polymersome Surfaces: Functionalization with Dendritic Groups submitted <br><br> 37. Zilinskas, G. J.; Soleimani, A.; Gillies, E. R.*  Poly(ester amide)-poly(ethylene oxide) graft copolymers: towards micellar drug delivery vehicles submitted<br><br> 36. Karamdoust, S.; Yu, B.; Bonduelle, C. V.; Liu, Y.; Davidson, G.; Stojcevic, G.; Yang, J.; Lau, W. M.; Gillies, E. R.* "A Simple and Selective Method for the Generation of Antibacterial Surfaces." J. Mat. Chem. in press. <br><br> 35. Wong, A. D.; DeWit, M. A.; Gillies, E. R.* "Amplified Release Through the Stimulus Triggered Degradation of Self-Immolative Dendrimers, Oligomers, and Linear Polymers." Adv. Drug Delivery Rev. in press <br><br> <h2><P align=left>2011</h2><br> <P align=left> 34. Thompson, D.B.; Trebicky, T.; Crewdson, P.; Matthew J. McEachran; Stojcevic, G.; Arsenault, G.; Lau, W. M.; Gillies, E. R.* "Functional Polymer Laminates from Hyperthermal Hydrogen Induced Cross-linking" Langmuir, 2011, 27, 14820-14827.<br><br> 33. Bonduelle, C. V.; Karamdoust, S.; Gillies, E. R.* "Synthesis and Assembly of Butyl Rubber-Poly(ethylene oxide) Graft Copolymers: From Surface Patterning to Resistance to Protein Adsorption." Macromolecules, 2011, 44, 6405-6415.<br><br> 32. Knight, D. K.; Gillies, E. R.; Mequanint, K.*  Vascular Smooth Muscle Cell Interactions on Biodegradable Poly(ester amide)s. Biomacromolecules, 2011, 12, 1275-1287.<br><br> 31. Bonduelle, C. V.; Lau, W. M.; Gillies, E. R.*  Preparation of Protein and Cell Resistant Surfaces by Hyperthermal Hydrogen Induced Cross-linking of Poly(ethylene oxide) ACS Appl. Mater. Interfaces, 2011, 3, 1740 1748.<br><br> 30. Nazemi, A.; Amos, R. C.; Bonduelle, C. V.; Gillies, E. R.*  Dendritic Surface Functionalization of Biodegradable Polymer Assemblies. J. Polym. Sci. A: Polym. Chem. 2011, 49, 2546 2559.<br><br> 29. DeWit, M. A.; Gillies, E. R.* " Design, Synthesis, and Cyclization of 4-Aminobutyric Acid Derivatives: Potential Candidates as Self-Immolative Spacers" Org. Biomol. Chem. 2011, 9, 1846 - 1854.<br><br> 28. Atkins, K. M.; Martinez, F. M.; Nazemi, A.; Scholl, T. J.; Gillies, E. R.* "Poly(para-phenylene ethynylene)s functionalized with Gd(III) chelates as potential MRI contrast agents." Can. J. Chem. 2011, 89, 47-56.<br><br> <h2><P align=left>2010</h2><br> <P align=left> 27. Bonduelle, C. V.; Gillies, E. R.*  Patterning of a Butyl Rubber-Poly(ethylene oxide) Graft Copolymer Revealed by Protein Adsorption. Macromolecules, 2010, 43, 9230-9233. <br><br> 26. DeWit, M. A.; Beaton, A.; Gillies, E. R. "A Reduction Sensitive Cascade Biodegradable Linear Polymer." J. Polym. Sci. A: Polym. Chem. 2010, 48, 3977-3985.<br><br> 25. Isimjan, T. T.; De Bruyn, J. R.; Gillies, E. R.*  Self-Assembly of Supramolecular Polymers from Beta-Strand Peptidomimetic-Poly(ethylene oxide) Hybrids." Macromolecules, 2010, 43, 4453 4459.<br><br> 24. Colin V. Bonduelle; Gillies, E. R.*  Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides.  Pharmaceuticals, 2010, 3(3), 636-666.<br><br> 23. Martin, A. L.; Hickey, J. L.; Ablack, A. L.; Lewis J. D.; Luyt, L. G.; Gillies, E. R.*  Synthesis of Bombesin Functionalized Iron Oxide Nanoparticles and Their Specific Uptake in Prostate Cancer Cells Journal of Nanoparticle Research, 2010, 12, 1599.<br><br> <h2><P align=left>2009</h2><br> <P align=left> 22. DeWit, M. A.; Gillies E. R.*  A Cascade Biodegradable Polymer Based on Alternating Cyclization and Elimination Reactions. J. Am. Chem. Soc. 2009, 131, 18327-18334.<br><br> 21. Watson, J. L.; Gillies, E. R.*  Amphipathic Beta-strand mimics as potential membrane active antibiotics. J. Org. Chem. 2009, 74, 5953-5960.<br><br> 20. Atkins, K. M.; Lopez, D.; Knight, D. K.; Mequanint, K.; Gillies, E. R.*  A Versatile Approach for the Syntheses of Poly(ester amide)s with Pendant Functional Groups. J. Polym. Sci. A: Polym. Chem. 2009, 47, 3757-3772.<br><br> 19. Martin, A. L.; Li, B.; Gillies, E. R.*  Surface Functionalization of Nanomaterials with Dendritic Groups: Towards Enhanced Binding to Biological Targets. J. Am. Chem. Soc. 2009, 131, 734-741.<br><br> <h2><P align=left>2008</h2><br> <P align=left> 18. Martin, A. L.; Bernas, L. M.; Rutt, B. K.; Foster, P. J.; Gillies, E. R.*  Enhanced Cell Uptake of Superparamagnetic Iron Oxide Nanoparticles Functionalized with Dendritic Guanidines. Bioconjugate Chem. 2008, 19, 2375-2384.<br><br> 17. Marquestaut, N. ; Martin, A. ; Talaga, D. ; Servant, L. ; Ravaine, S. ; Reculusa, S. ; Bassani, D. M. ; Gillies, E. R. ; Lagugné-Labarthet, F. *  Raman Enhancement of Azobenzene Monolayers on Substrates Prepared by Langmuir-Blodgett Deposition and E-beam lithography Techniques. Langmuir, 2008, 24, 11313-11321.<br><br> 16. De Wit, M. A.; Wang, Z.; Atkins, K. M.; Mequanint, K.*; Gillies, E. R.*  "Syntheses, characterization, and functionalization of poly(ester amide)s with pendant amine functional groups" J. Polym. Sci. A: Polym. Chem. 2008, 46, 6376-6392.<br><br> <h2><P align=left>2007</h2><br> <P align=left> 15. Li, B.; Martin, A. L. ; Gillies, E. R.*  Multivalent polymer vesicles via surface functionalization Chem. Commun. 2007, 48, 5217-5219.<br><br> 14. Shirude, P. S.; Gillies, E. R.; Ladame, S.; Godde, F.; Shin-ya, K.; Huc, I.*; Balasubramanian, S.*  Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands. J. Am. Chem. Soc. 2007, 129, 39, 11890-11891.<br><br> 13. Gillies, E. R.; Deiss, F.; Staedel, C.; Schmitter, J.-M.; Huc, I.*  Development and biological assessment of fully water soluble helical aromatic amide foldamers. Angew. Chem. Int. Ed. 2007, 46, 4081-4084.<br><br><br> <h2><P align=left>2002-2006</h2><br> <P align=left> 12. Lee, C.; Gillies, E. R.; Dy, E.; Fox, M. E.; Cramer, A. T.; Fréchet, J. M. J.*; Dy, E. E.; Szoka, F. C.* "A Single Dose of Doxorubicin-functionalized Bow-tie Dendrimer Cures Mice Bearing C-26 Colon Carcinomas." Proc. Nat. Acad. Sci. USA, 2006, 45, 16649-16654.<br><br> 11. Gillies, E. R.; Dolain, C. ; Léger, J. M. ; Huc, I.*  Amphipathic helices from aromatic amino acid oligomers. J. Org. Chem. 2006, 71, 7931-7939. <br><br> 10. Gillies, E. R.; Dy, E.; Fréchet, J. M. J.*; Szoka, F. C.*  Biological Evaluation of Polyester Dendrimer-Poly(ethylene oxide)  Bow-Tie Hybrids with Tunable Molecular Weight and Architecture. Molecular Pharmaceutics 2005, 2, 129-138. <br><br> 9. Gillies, E. R.; Fréchet, J. M. J.*  pH-Responsive Copolymer Assemblies for Controlled Release of Doxorubicin. Bioconjugate Chem. 2005, 16, 361-368.<br><br> 8. Kwon, Y. J.; Standley, S. M.; Goodwin, A. P.; Gillies, E. R.; Fréchet, J. M. J.*  Directed Antigen Presentation Using Polymeric Microparticulate Carriers Degradable at Lysosomal pH for Controlled Immune Responses. Molecular Pharmaceutics 2005, 2, 83-91.<br><br> 7. Gillies, E. R.; Fréchet, J. M. J.*  Dendrimers and Dendritic Polymers in Drug Delivery. Drug Discovery Today, 2005, 10, 35-43.<br><br> 6. Gillies, E. R.; Goodwin, A. P.; Fréchet, J. M. J.*  Acetals as pH-Sensitive Linkages for Drug Delivery. Bioconjugate Chem. 2004, 15, 1254-1263.<br><br> 5. Gillies, E. R.; Fréchet, Jean M. J. *  Development of Acid Sensitive Copolymer Micelles for Drug Delivery. Pure and Applied Chem., 2004, 76, 1295-1308.<br><br> 4. Gillies, E. R.; Jonsson, T. B.; Fréchet, J. M. J.*  Stimuli-Responsive Supramolecular Assemblies of Linear-Dendritic Copolymers. J. Am. Chem. Soc. 2004, 126, 11936-11943.<br><br> 3. Gillies, E. R.; Fréchet, J. M. J.*  Self-Assembly of Supramolecular Dendritic Bow-Ties: Effect of Peripheral Functionality on Association Constants. J. Org. Chem. 2004, 69, 46-53.<br><br> 2. Gillies, E. R.; Fréchet, J. M. J.*  A New Approach Towards Acid Sensitive Copolymer Micelles for Drug Delivery. Chem. Commun. 2003, 14, 1640-1641.<br><br> 1. Gillies, E. R.; Fréchet, J. M. J.*  Designing Macromolecules for Therapeutic Applications: Polyester Dendrimer-Poly(ethylene oxide) "Bow-Tie" Hybrids with Tunable Molecular Weight and Architecture. J. Am. Chem. Soc. 2002, 124, 14137-14146.<br><br> <h2><P align=left>Book Chapters</h2><br> <P align=left> 2. DeWit, M. A.; Nazemi, A.; Karamdoust, S.; Beaton, A.; Gillies, E. R.*  Design, Synthesis and Assembly of Self-Immolative Linear Block Copolymers. ACS Symposium Series, in press.<br><br> 1. Gillies, E. R.  Glycodendrimers and Their Biological Applications in  Engineered Carbohydrate-Based Materials for Biomedical Applications: Polymers, Surfaces, Dendrimers, Nanoparticles, and Hydrogels Narain, R. Ed., John Wiley and Sons, Hoboken, New Jersey, 2011, 261-306.<br><br> <h2><P align=left>Patents</h2><br> <P align=left> 2. Gillies, E. R.; Bonduelle, C. V.; Karamdoust, S. K.; Stojcevic, G.; Ferrari, L. P.; Adkinson, D. K.  Methods for Preparation of Novel Graft Copolymers PCT/CA2011/050487 Filed Aug. 11, 2011<br><br> 1. Gillies, E. R.; Bonduelle, C. V.; McEachran, M. J.; Stojcevic, G.; Arsenault, G.  Oxygenated Butyl Rubber as Compatibilizer for the Deposition of Hydrophilic Polymers on Butyl. PCT/CA2011/050488 Filed Aug. 11, 2011<br><br> <h2><P align=left>Conference Proceedings</h2><br> <P align=left> 13. Chen, E. K. Y.; DeWit, M. A.; Beaton, A.; Wong, A.; Gillies, E. R.*  Cascade Degradable Polymers  A New Approach to Biomaterials. Proc. 29th Ann. Meeting of Can. Biomat. Soc., Vancouver, Can., June 1-4, 2011.<br><br> 12. Homenick, C. M.; Atkins, K. M.; Mackey, V.; Maris, M.; Soleimani, R.; Gillies, E. R.*  Novel MRI Contrast Agents from Polymer-Based Gadolinium Complexes. Proc. 29th Ann. Meeting of Can. Biomat. Soc., Vancouver, Can., June 1-4, 2011.<br><br> 11. Bonduelle, C. V.; Nazemi, A.; Amos, R.; Martin, A.; Li, B.; Gillies, E. R.*  Surface Functionalized Polymersomes for Enhanced Cell Uptake and Binding to Biological Targets. 2010, Polymer Preprints, 51, 295-296.<br><br> 10. Bonduelle, C. V.; Karamdoust, S.; Thompson, D. B.; Trebicky, T.; Davidson, G.; Arsenault, G.; Lau, W. M.; Gillies, E. R.*  Preparation of Functional Polymer Surfaces by Hyperthermal Hydrogen Induced Cross-Linking. 2010, Polym. Mat. Sci. Eng.<br><br> 9. Zilinskas, G. J.; Gillies, E. R.*  Poly(ester amide) Nanoparticles for the Covalent Immobilization of Drugs. Proc. 29th Ann. Meeting of Can. Biomat. Soc., Kingston, Can., June 3-4, 2010.<br><br> 8. Knight, D. K.; Gillies, E. R.*; Mequanint, K.*  Functionalized Poly(ester amide)s as Tissue Engineering Scaffolds. Proc. 28th Ann. Meeting of Can. Biomat. Soc., Kingston, Can., June 3-4, 2010.<br><br> 7. DeWit, M. A.; Beaton, A.; Gillies, E. R.  Design and Synthesis of Cascade Degradable Linear Block Copolymers. Polymer Preprints, 2010, 51, 311-312.<br><br> 6. Knight, D. K.; Atkins, K. M.; DeWit, M. A.; Wang, Z.; Lopez, D.; Mequanint, K.; Gillies, E. R.  Functionalized Poly(ester amide)s as Scaffolds for Vascular Tissue Engineering. Polymer Preprints, 2010, 51, 37-38.<br><br> 5. Knight, D. K., Lopez, D., Atkins, K., Gillies, E. R., Mequanint, K.  Functionalized Poly(ester amide) Biomaterials Proc. 27th Ann. Meeting of Can. Biomat. Soc., Quebec City, Canada, May 20-23, 2009.<br><br> 4. Gillies, E. R.; Li, B.; Martin, A.  Surface Functionalized Polymer Vesicles for Controlled Biocompatibility, Cell Uptake, and Targeting.  2008, Polym. Mat. Sci. Eng. 98, 311-312.<br><br> 3. Gillies, E. R.; Martin, A. L.; Bernas, L.; Rutt, B. K.  Iron Oxide Nanoparticles with Functional Polymer Coatings: Contrast Agents for Magnetic Resonance Imaging. 2008, Polymer Preprints, 49(1), 848-849.<br><br> 2. Li, B.; Martin, A.; Maris, M.; Gillies, E. R.  Surface Functionalization Approaches for Polymer Vesicles: Controlling Biocompatibility, Cell Uptake, and Targeting Proc. 26th Ann. Meeting of Can. Biomat. Soc., London, Canada, May 25-27, 2007.<br><br> 1. Lee, C.; Gillies, E. R.; Yoshida, M.; Dy, E.; Szoka, F. C.; Fréchet, Jean M. J.  Polymers with dendritic architectures for drug delivery: Synthesis and biological evaluation. Polym. Mat. Sci. Eng. 2004, 91, 54-55.<br><br> </td> </font> <br> <br> <center> <font size="-1"><br>© F.L.L Nov. 2008. All Rights Reserved. &nbsp;</font><br> <font size="-1"> <a href="mailto:egillie@uwo.ca">egillie(at)uwo.ca</a><br> Last Updated: Feb 2012&nbsp; </font> </center> </tr></td> </p> </div> </td> </tr> &nbsp &nbsp </table> </body> </html>