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2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004
| 2003 | 2002 | 2001 | 2000 | 1999
| earlier work "Validation of
Membrane Protein Topology Models by Oxidative Labeling and Mass
Spectrometry" Y. Pan, X. Ruan, M. A. Valvano, and L. Konermann J. Am. Soc. Mass Spectrom.
in press (2012).
"Conformational Dynamics of a Membrane Transport Protein Probed by H/D Exchange and Covalent Labeling: The Glycerol Facilitator" Y. Pan, H. Piyadasa, J. D. O'Neil, and L. Konermann J. Mol. Biol. in press (2012). "Correction of both NBD1 energetics and domain interface is required to restore Delta F508 CFTR folding and function" W. M. Rabeh, F. Bossard, H. Xu, T. Okiyoneda, M. Bagdany, C. M. Mulvihill, K. Du, S. di Bernardo, Y. Liu, L. Konermann, A. Roldan, G. L. Lukacs Cell 148, 150-163 (2012). Online Access. "Modeling the Behavior of Coarse-Grained Polymer Chains in Charged Water Droplets: Implications for the Mechanism of Electrospray Ionization" Elias Ahadi and Lars Konermann J. Phys. Chem. B 116, 104–112 (2012). Online access. Supporting Information (MPEG video): hydrophobic/folded polymer chain, hydrophobic/unfolded polymer chain hydrophilic/folded polymer chain, hydrophilic/unfolded polymer chain   back to top 2011 "Hydrogen Exchange Mass Spectrometry of Bacteriorhodopsin Reveals Light-Induced Changes in the Structural Dynamics of a Biomolecular Machine" Y. Pan, L. Brown, and L. Konermann J. Am. Chem. Soc. 133, 20237–20244 (2011). Online access.  "Ejection of Solvated Ions from Electrosprayed Methanol/Water Nanodroplets Studied by Molecular Dynamics Simulations" E. Ahadi and L. Konermann J. Am. Chem. Soc. 133, 9354–9363 (2011). Online access. Supporting Information (MPEG video): water droplet, water/methanol droplet, methanol droplet    "Temporal Development of Protein Structure During S100A11 Folding and Dimerization Probed by Oxidative Labeling and Mass Spectrometry" B. B. Stocks, A. Rezvanpour, G. S. Shaw, and L. Konermann J. Mol. Biol. 409, 669-679 (2011). Online access.  "Hydrogen Exchange
Mass Spectrometry for Studying Protein Structure and Dynamics" L.
Konermann, J. Pan, and Y.-H. Liu Chem.
Soc. Rev. 40, 1224-1234 (2011). Online
access.
 "An Electrostatic
Charge Partitioning Model for the Dissociation of Protein Complexes in
the Gas Phase" S. V. Sciuto, J. Liu, and L. Konermann, J. Am. Soc. Mass Spectrom. 22 1679-1689
(2011). Online
access.
"Protein Folding Mechanisms Studied by Pulsed Oxidative Labeling and Mass Spectrometry" L. Konermann, Y. Pan, and B. B. Stocks Curr. Op. Struct. Biol. 21, 634-640 (2011). Online access. "Probing the Metal Composition of Ternary 12-12´-16 Nanoclusters via Electrospray Ionization Mass Spectrometry" A. Howarth, J. Liu, L. Konermann, and J. F. Corrigan Z. Anorg. Allg. Chem. 637, 1203-1206 (2011). Online access. "Protein-Protein Binding Affinities In Solution Determined by Electrospray Mass Spectrometry" J. Liu and L. Konermann J. Am. Soc. Mass Spectrom. 22, 408-417 (2011). Online access. back to top
"Surface Charge of
Electrosprayed Water Nanodroplets: A Molecular Dynamics Study" E. Ahadi
and L. Konermann  "Site-Directed
Mutagenesis Combined with Oxidative Methionine Labeling for Probing
Structural Transitions of a Membrane Protein by Mass Spectrometry" Y.
Pan, L. Brown, and L. Konermann J.
Am. Soc. Mass Spectrom. 21,
1947-1956 (2010). Online
access.
 "Calcium-Induced Structural Transitions of the Calmodulin-Melittin System Studied by Electrospray Mass Spectrometry: Conformational Sub-Populations and Metal-Unsaturated Intermediates" J. Pan and L. Konermann Biochemistry 49, 3477–3486 (2010). Online access.   "Characterizing Short-Lived Protein Folding Intermediates by Top-Down Hydrogen Exchange Mass Spectrometry" J. Pan, J. Han, C. H. Borchers, and L. Konermann Anal. Chem., 82 8591-8597 (2010). Online access. "Mass Spectrometry Combined with Oxidative Labeling for Exploring Protein Structure and Folding" L. Konermann, B. B. Stocks, Y. Pan, and X. Tong Mass Spectrom. Rev. 29 651-667 (2010). Online access. "Time-Dependent Changes in Side Chain Solvent Accessibility During Cytochrome c Folding Probed By Pulsed Oxidative Labeling and Mass Spectrometry" B. B. Stocks and L. Konermann J. Mol. Biol. 398, 362-373 (2010). Online access. back to top "Hydrogen/Deuterium Exchange Mass Spectrometry with Top-Down Electron Capture Dissociation for Characterizing Structural Transitions of a 17 kDa Protein" J. Pan, J. Han, C. H. Borchers, and L. Konermann J. Am. Chem. Soc. 131, 12801–12808 (2009). Online access.  "Phosphorylation-Induced Activation of the Response Regulator VraR from Staphylococcus aureus: Insights from Hydrogen Exchange Mass Spectrometry" Y.-H. Liu, A. Belcheva, L. Konermann*, and D. Golemi-Kotra* J. Mol. Biol. 391, 149-163 (2009). Online access. Cover feature. Click on image for larger version.  "Irreversible Thermal Denaturation of Cytochrome c Studied by Electrospray Mass Spectrometry" J. Liu and L. Konermann J. Am. Soc. Mass Spectrom. 20, 819-828 (2009). Online access.  "Formation of Monomeric S100B and S100A11 Proteins at Low Ionic Strength" N. Marlatt, B. L. Boys, L. Konermann, and G. S. Shaw Biochemistry, 48 1954–1963 (2009). Online access.  "A Simple Model for the Disintegration of Highly Charged Solvent Droplets during Electrospray Ionization" L. Konermann J. Am. Soc. Mass Spectrom. 20, 496-506 (2009). Online access.  "Structural Characterization of an Integral Membrane Protein in its Natural Lipid Environment by Oxidative Methionine Labeling and Mass Spectrometry" Y. Pan, B. B. Stocks, L. Brown, and L. Konermann Anal. Chem. 81, 28-35 (2009). Online access. "Structural Characterization of Short-Lived Protein Unfolding Intermediates by Laser-Induced Oxidative Labeling and Mass Spectrometry" B. B. Stocks and L. Konermann Anal. Chem. 81, 20-27 (2009). Online access. "Mapping the Structure of an Integral Membrane Protein under Semi-Denaturing Conditions by Laser-Induced Oxidative Labeling and Mass Spectrometry" Y. Pan, L. Brown, and L. Konermann J. Mol. Biol. 394, 968-981 (2009). Online access. "Solution-Phase Chelators for Suppressing Nonspecific Protein-Metal Interactions in Electrospray Mass Spectrometry" J. Pan, K. Xu, X. Yang, W.-Y. Choy, and L. Konermann Anal. Chem. 81, 5008-5015 (2009). Online access. "Protein Oxidative Modifications During Electrospray Ionization: Solution Phase Electrochemistry or Corona Discharge-Induced Radical Attack?" B. L. Boys, M. C. Kuprowski, J. J. Noël, and L. Konermann Anal. Chem. 81, 4027-4034 (2009). Online access. "Molecular Dynamics Simulations of Electrosprayed Water Nanodroplets: Internal Potential Gradients, Location of Excess Charge Centers, and 'Hopping' Protons" E. Ahadi and L. Konermann J. Phys. Chem. B 113, 7071-7080 (2009). Online access. "Protein Folding and Protein-Ligand Interactions Monitored by Electrospray Mass Spectrometry“ P. L. Ferguson, M. C. Kuprowski, B. L. Boys, D. J. Wilson, J. Pan, and L. Konermann, Curr. Anal. Chem. 5, 186-204 (2009). Online access. "Biochemical Reaction Kinetics Studied by Time-Resolved Electrospray Ionization Mass Spectrometry" L. Konermann, J. Pan, and D. J. Wilson, in Mass Spectrometry Analysis of Proteins, Editor: J. Whitelegge. Series: Comprehensive Analytical Chemistry, Vol. 52; Elsevier, Amsterdam, The Netherlands, Chapter 5, 103-126 (2009). More information. "Electron Capture Dissociation of Electrosprayed Protein Ions for Spatially-Resolved Hydrogen Exchange Measurements" J. Pan, J. Han, C. H. Borchers, and L. Konermann J. Am. Chem. Soc. 130, 11574-11575 (2008). Online access.  "Protein structure and dynamics studied by mass spectrometry: H/D exchange, hydroxyl radical labeling, and related approaches" L. Konermann, X. Tong, and Y. Pan J. Mass Spectrom. 43, 1021-1036 (2008). Cover feature. Click on image for larger version. Online access.  "Conformational Dynamics of Free and Catalytically Active Thermolysin Are Indistinguishable by H/D Exchange Mass Spectrometry" Y.-H. Liu and L. Konermann, Biochemistry 47, 6342-6351 (2008). Online access.  "Non-Uniform Isotope Patterns Produced by Collision-Induced Dissociation of Homogeneously Labeled Ubiquitin: Implications for Spatially-Resolved H/D Exchange ESI-MS Studies“ P. L. Ferguson and L. Konermann, Anal. Chem. 80, 4078-4086 (2008). Online access. "Gamma-Ray-Mediated Oxidative Labeling for Detecting Protein Conformational Changes by Electrospray Mass Spectrometry" X. Tong, J. C. Wren, and L. Konermann, Anal. Chem. 80, 2222-2231 (2008). Online access. "Mass Spectrometry-Based Methods for Studying Kinetics and Dynamics in Biological Systems" L. Konermann, J. Messinger, and W. Hillier, Biophysical Techniques in Photosynthesis, Vol. 2 (T.J. Aartsma and J. Matysik, eds.) Series: Advances in Photosynthesis and Respiration. Springer, Dordrecht, 167-190 (2008). More information. "Time-Resolved
Electrospray Mass Spectrometry" L. Konermann,
D. J. Wilson, and D. A. Simmons, Protein Structures:
Methods in Protein Structure and Stability Analysis, Editors: V. N. Uversky
and E. A. Permyakov, Nova Science
Publishers, Inc., New York. Chapter 2.1, 95-119 (2008). More
information.
"Diversity of Penicillin-Binding Proteins: Resistance Factor FmtA of Staphylococcus Aureus" X. Fan, Y.-H. Liu, D. Smith, L. Konermann, K.W. M. Siu and D. Golemi-Kotra J. Biol. Chem. 282, 35143-35152 (2007). Online access. "Effects of Zinc Binding on the Structure and Dynamics of the Intrinsically Disordered Protein Prothymosin α: Evidence for Metalation as an Entropic Switch" S. Yi, B. L. Boys, A. Brickenden, L. Konermann, and W.-Y. Choy Biochemistry 46 13120-13130 (2007). Online access.  "Symmetric Behavior of Hemoglobin α and β Subunits During Acid-Induced Denaturation Observed by Electrospray Mass Spectrometry" B. L. Boys, M. C. Kuprowski, and L. Konermann Biochemistry 46, 10675 -10684 (2007). Online access.  "Effects of Protein Concentration on the Extent of Gamma-Ray-Mediated Oxidative Labeling Studied by Electrospray Mass Spectrometry" X. Tong, J. C. Wren, and L. Konermann, Anal. Chem. 79, 6376-6382 (2007). Online access. "Analysis of Protein Mixtures by Electrospray Mass Spectrometry: Effects of Conformation and Desolvation Behavior on the Signal Intensities of Hemoglobin Subunits" M. C. Kuprowski, B. L. Boys, and L. Konermann, J. Am. Soc. Mass Spectrom.18, 1279-1285 (2007). Online access.  "A Minimalist Model for Exploring Conformational Effects on the Electrospray Charge State Distribution of Proteins" L. Konermann J. Phys. Chem. B 111, 6534-6543 (2007). Online access. "Signal Response of Co-Existing Protein Conformers in Electrospray Mass Spectrometry" M. C. Kuprowski and L. Konermann, Anal. Chem. 79, 2499-2506 (2007). Online access. "A Temperature-Jump Stopped-Flow System for Monitoring Chemical Kinetics Triggered by Rapid Cooling" B. L. Boys and L. Konermann, Talanta 71 1276–1281 (2007). Online access. "Folding and Assembly of Hemoglobin Monitored by Electrospray Mass Spectrometry Using an On-line Dialysis System" B. L. Boys and L. Konermann, J. Am. Soc. Mass Spectrom. 18, 8-16 (2007). Cover feature. Click on image for larger version. Online access, download statistics.  "Hydrogen/Deuterium Scrambling During Quadrupole-Time-of-Flight MS/MS Analysis of a Zinc-Binding Protein Domain" P. L. Ferguson, J. Pan, D. J. Wilson, B. Dempsey, G. Lajoie, B. Shilton, and L. Konermann, Anal. Chem. 79, 153-160 (2007). Online access. "Time-Resolved ESI-MS" L. Konermann, J. Pan, D. A. Simmons, and D. J. Wilson The Encyclopedia of Mass Spectrometry, Vol. 6 (Editors: M. L. Gross and R. M. Caprioli), Elsevier, Amsterdam 802-810 (2007). More information. back to top
"Enzyme conformational dynamics during catalysis and in the 'resting state' monitored by hydrogen/deuterium exchange mass spectrometry" Y.-H. Liu and L. Konermann, FEBS Lett. 580 5137-5142 (2006). Online access. "Exploring the Relationship Between Funneled Energy Landscapes and Two-State Protein Folding" L. Konermann Proteins: Structure, Function, and Bioinformatics 65, 153-163 (2006). Online access. "Folding Kinetics of the S100A11 Protein Dimer Studied by Time-Resolved Electrospray Mass Spectrometry and Pulsed Hydrogen/Deuterium Exchange" J. Pan, A. C. Rintala-Dempsey, Y. Li, G. S. Shaw, and L. Konermann Biochemistry 45, 3005-3013 (2006). Featured as April 2006 Hot Article. Online access.  "Pulsed Hydrogen/Deuterium Exchange MS/MS for Studying the Relationship between Noncovalent Protein Complexes in Solution and in the Gas-Phase after Electrospray Ionization" B. M. Hossain and L. Konermann Anal. Chem. 78, 1613-1619 (2006). Online access. "Protein Folding Mechanisms Studied by Time-Resolved Electrospray Mass Spectrometry" L. Konermann, J. Pan, and D. J. Wilson Biotechniques 40, 135-141 (2006). Online access. back to top "Ultrarapid Desalting of Protein Solutions for
Electrospray
Mass Spectrometry in a Microchannel Laminar Flow Device" D. J. Wilson
and L. Konermann Anal.
Chem. 77,
6887-6894 (2005). Online
access. "Mass spectrometry-based approaches to protein-ligand interactions" S. M. Schermann, D. A. Simmons, and L. Konermann Exp. Rev. Proteomics 2, 475-485 (2005). Online access. "Pulsed Hydrogen Exchange and Electrospray Charge-State Distribution as Complementary Probes of Protein Structure in Kinetic Experiments: Implications for Ubiquitin Folding" J. Pan, D. J. Wilson, and L. Konermann Biochemistry 44, 8627-8633 (2005). Online access.  "Do Electrospray Mass Spectra Reflect the Ligand Binding State of Proteins in Solution? " B. M. Hossain, D. A. Simmons, and L. Konermann, Can. J. Chem. (Special Issue: Dedicated to Professor P. Kebarle) 83, 1953-1960 (2005). Online access. 
"The reconstitution of unfolded myoglobin with hemin dicyanide is not accelerated by fly-casting" M. O. Crespin, B. L. Boys and L. Konermann, FEBS Lett. 579, 271-274 (2005). Online access. "Subunit Disassembly and Unfolding Kinetics of Hemoglobin Studied by Time-Resolved Electrospray Mass Spectrometry" D. A. Simmons, D. J. Wilson, G. A. Lajoie, A. Doherty-Kirby, and L. Konermann, Biochemistry 43, 14792-14801 (2004). Online access.
"2003 Fred Beamish Award Lecture - Exploring the Dynamics of Biological Systems by Mass Spectrometry" L. Konermann, Can. J. Chem. 82, 1565-1580 (2004). Cover feature. Click on image for larger version. Online access.
"Effects of Ground Loop Currents on Signal Intensities in Electrospray Mass Spectrometry" R. A. Ochran and L. Konermann, J. Am. Soc. Mass Spectrom. 15, 1748-1754 (2004). Online access. "Determination of Ligand-Protein Dissociation Constants by Electrospray Mass Spectrometry-Based Diffusion Measurements" S. M. Clark and L. Konermann, Anal. Chem. 76, 7077-7083 (2004). Online access. "Mechanistic Studies on Enzymatic Reactions by ESI-MS Using a Capillary Mixer With Adjustable Reaction Chamber Volume for Time-Resolved Measurements" D. J. Wilson and L. Konermann, Anal. Chem. 76, 2537-2543 (2004). Online access. "Screening for Noncovalent Ligand-Receptor Interactions by Electrospray Ionization Mass Spectrometry-Based Diffusion Measurements" S. M. Clark and L. Konermann, Anal. Chem. 76, 1257-1263 (2004). Online access. "A Capillary Mixer With Adjustable Reaction Chamber Volume for Millisecond Time-Resolved Studies by Electrospray Mass Spectrometry" D. J. Wilson and L. Konermann, Anal. Chem. 75, 6408-6414 (2003). Online access. "Conformational Dynamics of Partially Denatured Myoglobin Studied by Time-Resolved Electrospray Mass Spectrometry With Online Hydrogen-Deuterium Exchange" D. A. Simmons, S. D. Dunn and L. Konermann Biochemistry 42, 5896-5905 (2003). Online access. See also Biochemistry 42, 9248 (2003). "Protein Folding Kinetics and Mechanisms Studied by Pulse-Labeling and Mass Spectrometry " L. Konermann and D. A. Simmons Mass Spectrom. Rev. 22, 1-26 (2003). Online access. "Implementation of a Multifunctional Logic Gate Based on Folding/Unfolding Transitions of a Protein" A. S. Deonarine, S. M. Clark and L. Konermann Future Generation Computer Systems 19, 87-97 (2003). Online access. "Diffusion Measurements by Electrospray Mass Spectrometry for Studying Solution-Phase Noncovalent Interactions" S. M. Clark and L. Konermann J. Am. Soc. Mass Spectrom. 14, 430-441 (2003). Online access. Konermann, Lars (January 2003 ) "Protein Unfolding and Denaturants". In: Nature Encyclopedia of Life Sciences. London: Nature Publishing Group. Online access. "Method and Apparatus for the Detection of Noncovalent Interactions by Mass Spectrometry-Based Diffusion Measurements" L. Konermann and S. M. Clark US Patent Application and PCT Application, filed May 30, 2003. "Characterization of Transient Protein Folding Intermediates During Myoglobin Reconstitution by Time-Resolved Electrospray Mass Spectrometry with On-Line Isotopic Pulse Labeling" D. A. Simmons and L. Konermann Biochemistry 41, 1906-1914 (2002). Online access. "Taylor Dispersion Monitored by Electrospray Mass Spectrometry: A Novel Approach for Studying Diffusion in Solution" S. M. Clark, D. G. Leaist, and L. Konermann Rapid Commun. Mass Spectrom. 16, 1454-1462 (2002). Online access. "Pre-Steady State Kinetics of Enzymatic Reactions Studied by Electrospray Mass Spectrometry with On-Line Rapid-Mixing Techniques" L. Konermann and D. J. Douglas, Meth. Enzymol. 354 (Enzyme Kinetics and Mechanism, Part F), 50-64 (2002). "Electrochemically Induced pH Changes Resulting in Protein Unfolding in the Ion Source of an Electrospray Mass Spectrometer" L. Konermann, E. A. Silva, and O. F. Sogbein, Anal. Chem. 73, 4836-4844 (2001). Online access. "From Small-Molecule Reactions to Protein Folding: Studying Biochemical Kinetics by Stopped-Flow Electrospray Mass Spectrometry" B. M. Kolakowski and L. Konermann Anal. Biochem. 292, 107-114 (2001). Online access. "Stopped-Flow-Electrospray
Ionization Mass Spectrometry : A New Method for Studying Chemical
Reaction Kinetics in Solution" B. M. Kolakowski, D. A. Simmons, and L.
Konermann Rapid Commun. Mass Spectrom. 14, 772-776 (2000). Online
access. "Method and apparatus for determining the rates of reactions in liquids by mass spectrometry " D. J. Douglas, L. Konermann, and B. A. Collings United States Patent 6054709, issued April 25, 2000. "Reconstitution
of Acid-Denatured Holo-Myoglobin Studied by Time-Resolved Electrospray
Ionization Mass Spectrometry", V. W. S. Lee, Y.-L. Chen, and L.
Konermann Anal. Chem. 71, 4154-4159 (1999). Online
access. "Protein Folding Studied by Electrospray Ionization Mass Spectrometry", L. Konermann, Science Progress 81, 123-140 (1998). "Unfolding
of Proteins Monitored by Electrospray Ionization Mass Spectrometry: A
Comparison of Positive and Negative Ion Modes", L. Konermann and D. J.
Douglas, J. Am. Soc. Mass Spectrom. 9, 1248-1254 (1998). "Stability of a Highly Charged Noncovalent Complex in the Gas Phase: Holomyoglobin", Y.-L. Chen, J. M. Campbell, B. A. Collings, L. Konermann, and D. J. Douglas, Rapid Commun. Mass Spectrom. 12, 1003-1010 (1998). "Acid-Induced
Unfolding of Cytochrome c at Different Methanol Concentrations:
Electrospray Ionization Mass Spectrometry Specifically Monitors Changes
in the Tertiary Structure", L. Konermann and D. J. Douglas, Biochemistry
36, 12296-12302 (1997). "Cytochrome c Folding Kinetics Studied by Time-Resolved Electrospray Ionization Mass Spectrometry" L. Konermann, B. A. Collings, and D. J. Douglas Biochemistry 36, 5554-5559 (1997). "The Use of a Long-Lifetime Component of Tryptophan to Detect Slow Orientational Fluctuations of Proteins" K. Döring, W. Beck, L. Konermann, and F. Jähnig Biophys. J. 72, 326-334 (1997). "Pigment Assignment in the Absorption Spectrum of the Photosystem II Reaction Center by Site-Selection Fluorescence Spectroscopy" L. Konermann, I. Yruela, and A. R. Holzwarth Biochemistry 36, 7498-7502 (1997). "Primary Processes and Structure of the Photosystem II Reaction Center. 5. Modeling of the Fluorescence Kinetics of the D1-D2-cyt-b559 Complex at 77 K" L. Konermann, G. Gatzen, and A. R. Holzwarth J. Phys. Chem. B 101, 2933-2944 (1997). "Analysis of the Absorption Spectrum of Photosystem II Reaction Centers: Temperature Dependence, Pigment Assignment and Inhomogeneous Broadening" L. Konermann, and A. R. Holzwarth Biochemistry 35, 829-842 (1996). "A Long Lifetime Component in the Tryptophan Fluorescence of Some Proteins" K. Döring, L. Konermann, T. Surrey, and F. Jähnig, Eur. Biophys. J. 23, 423-432 (1995). Home | Lars Konermann | Research | People | Publications | News
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