Matthew G. Teeter, Ph.D. Bio News Research Publications


Scientist, Lawson Health Research Institute
Scientist, Robarts Research Institute
Assistant Professor, Medical Biophysics and Surgery
Schulich School of Medicine & Dentistry, Western University
E: matthew.teeter@lhsc.on.ca
T: 519-685-8500 ext 34957 (UH)
T: 519-661-2111 ext 24404 (RRI)
M: 339 Windermere Road, London, ON, N6A 5A5



Photo by Jesica Hurst, Schulich Communications



Bio

Dr. Matthew Teeter leads the basic science research program for the Joint Replacement Institute at London Health Sciences Centre, University Hospital. He is a Scientist at the Lawson Health Research Institute, Scientist at the Robarts Research Institute, and an Assistant Professor in the Departments of Medical Biophysics and Surgery, Schulich School of Medicine & Dentistry at Western University. Dr. Teeter’s research focuses on image-based orthopedic implant design and evaluation, including 3D printing technologies and imaging techniques such as micro-CT, CT, RSA, and single-plane fluoroscopy. He has a particular interest in implant wear, and directs the Implant Retrieval Laboratory at LHSC. Recent projects also include examining the use of wearable sensor to better direct and evaluate treatment for orthopaedic conditions. Dr. Teeter received his BSc in Biomedical Science from the University of Guelph and his PhD in Medical Biophysics from Western University, where he was a Graduate Fellow in Musculoskeletal Health Research and Leadership as part of the
Canadian Institutes of Health Research (CIHR) Joint Motion Program. He received national awards at all levels of his graduate and fellowship training from the CIHR. In 2012, he received the Mark Coventry Award for Best Science Paper from the Knee Society, and in 2015 was awarded the John Charles Polanyi Prize in Physiology or Medicine from the Province of Ontario. In 2016 he received an Ontario Early Researcher Award and a CIHR New Investigator Award. Dr. Teeter has an active interest in the commercialization of research innovations, and has taught courses on Scientific Communications in the Medical Biophysics graduate program, and on Research Translation in the Biomedical Engineering graduate program at Western University. He is also a co-founder and inaugural co-director of the Western Medical Innovation Fellowship program.



News

Some stories related to my work:

The Teeter Lab in Summer 2016
The Teeter Lab in Summer 2016.



Research

The majority of my research involves the application of medical imaging techniques to design or evaluate orthopaedic implants and other interventions for treating musculoskeletal disorders. In conducting this research I work in close collaboration with orthopaedic surgeons, imaging scientists, and biomedical engineers. Much of the orthopaedic research being accomplished in the City of London is described on Lawson's Orthopaedic Research website, including photos of my lab and infrastructure. I am a member of Western's Bone & Joint Institute and participate in the Collaborative Graduate Program in Musculoskeletal Health. I supervise graduate students in the Medical Biophysics, Biomedical Engineering, Kinesiology, Electrical and Computer Engineering, and MSc in Surgery graduate programs. I also supervise undergraduate students as part of summer projects, 3rd or 4th year projects, and co-op terms. Please contact me if you are interested in joining the lab. My research program is funded by CIHR, NSERC, The Arthritis Society, the Canadian Orthopaedic Foundation, Ontario Ministry of Research, Innovation, and Science, and from industry, among others. My main areas of research interest include:

3D geometry acquired by micro-CT Implant Retrievals
I developed a new technique using micro-CT imaging to measure and map deviations due to wear in implants that have undergone wear testing or that have failed and been retrieved from patients undergoing revision surgery. I also direct Canada’s first and largest implant retrieval laboratory, with over 3,000 failed hip, knee, and shoulder implants. Methods such as micro-CT, visual damage scoring, profilometry, SEM/EDX, and finite element analysis are used to evaluate the metal and plastic components used in joint replacement implants. Some representative projects can be found here, here, and here.

RSA Imaging
Radiostereometric analysis (RSA) uses calibrated biplane x-rays to quantify the migration and wear of implants over time. I use RSA to evaluate the safety and effectiveness of new implant designs and surgical techniques in patients, and am working on ways to combine RSA analysis with standard clinical follow-up images. I am also a founding member of the Canadian RSA Network, which coordinates multi-centre trials of news implants across the country. Representative projects can be found here, here, and here.
RSA Imaging Suite

Fluoroscopic image of a patient with a high tibial osteotomy Single-Plane Fluoroscopy
Our joints are made to let us move, so to evaluate them we need to use moving x-rays, or fluoroscopy. I use fluoroscopic imaging of patients while they are performing activities (such as a step-up or deep knee bend) to evaluate surgical techniques and implants. As part of a new facility at Fowler-Kennedy Sports Medicine Clinic, we are implementing single-plane fluoroscopy with 3D gait analysis, an instrumented treadmill, and virtual reality environment. Representative projects can be found here and here.

Additive Manufacturing
I use selective laser melting (SLM) to 3D print components in metals such as stainless steel, titanium, and cobalt-chrome. This builds directly off of previous work in reverse engineering implants using micro-CT, and evaluating different design factors. With collaborators I am designing new components to address periprosthetic infection and complex revision cases. A representative project can be found here.
Photo of implant produced from additive manufacturing

Photo of a wearable knee sensor system currently under development
Wearable Sensors
Patient outcome questionnaires have ceiling effects limiting their ability to differentiate subtle differences between patients, and advanced imaging can only be applied in limited clinical trial settings. Wearable sensor technology is rapidly improving and becoming more prevalent, and may offer a better, inexpensive way to evaluate patients with arthritis before and after interventions. With collaborators, I am using consumer activity monitors to track activity during recovery following hip replacement, developing a novel wearable sensor system to track knee flexion, and correlating sensor-measured motion at the shoulder to RSA measures of implant performance.



Publications

For the most up to date listing of my publications, search PubMed for "Teeter MG". I can also be found on Google Scholar, ResearcherID, and ResearchGate.

I also present my research at national and international conferences such as the Canadian Orthopaedic Research Society, Canadian Orthopaedic Association, Canadian Arthroplasty Society, Orthopaedic Research Society, American Academy of Orthopaedic Surgeons, International RSA Meeting, and the International Society for Technology in Arthroplasty.