Publications by Peter Chidiac


2016
  1. Chidiac, P. RGS proteins destroy spare receptors: Effects of GPCR-interacting proteins and signal deamplification on measurements of GPCR agonist potency. Methods. 2016 Jan 1;92:87-93. doi: 10.1016/j.ymeth.2015.08.011.   PDF

  2. Narla C, Scidmore T, Jeong J, Everest M, Chidiac P, Poulter MO. A switch in G protein coupling for type 1 corticotropin-releasing factor receptors promotes excitability in epileptic brains. Sci Signal. 2016 Jun 14;9(432):ra60. doi: 10.1126/scisignal.aad8676.   PDF

2015
  1. Chidiac P, Hebert TE. GPCR Retreat 2014: a good view leads to many discoveries!. J Recept Signal Transduct Res. 2015 Jun;35(3):208-12. doi: 10.3109/10799893.2015.1072977.  

  2. Bernhardt ML, Lowther KM, Padilla-Banks E, McDonough CE, Lee KN, Evsikov AV, Uliasz TF, Chidiac P, Williams CJ, Mehlmann LM. Regulator of G-protein signaling 2 (RGS2) suppresses premature calcium release in mouse eggs. Development. 2015 Aug 1;142(15):2633-40. doi: 10.1242/dev.121707.   PDF

  3. Zhao P, Chidiac P. Regulation of RGS5 GAP activity by GPSM3. Mol Cell Biochem. 2015 Jul;405(1-2):33-40. doi: 10.1007/s11010-015-2393-3.   PDF

2014
  1. Thompson MD, Cole DE, Jose PA, Chidiac P. G protein-coupled receptor accessory proteins and signaling: pharmacogenomic insights. Methods Mol Biol. 2014;1175:121-52. doi: 10.1007/978-1-4939-0956-8_7.   PDF

  2. Chidiac P, Sobiesiak AJ, Lee KN, Gros R, Nguyen CH. The eIF2B-interacting domain of RGS2 protects against GPCR agonist-induced hypertrophy in neonatal rat cardiomyocytes. Cell Signal. 2014 Jun;26(6):1226-34. doi: 10.1016/j.cellsig.2014.02.006.   PDF

2013
  1. Zhao P, Cladman W, Van Tol HH, Chidiac P. Fine-tuning of GPCR signals by intracellular G protein modulators. Prog Mol Biol Transl Sci. 2013;115:421-53. doi: 10.1016/B978-0-12-394587-7.00010-5.   PDF

  2. Chidiac P, Hebert TE. GPCR Retreat 2012: timing is everything. J Recept Signal Transduct Res. 2013 Jun;33(3):129-34. doi: 10.3109/10799893.2012.759592.  

  3. Zhao P, Nunn C, Ramineni S, Hepler JR, Chidiac P. The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins. J Cell Biochem. 2013 Jun;114(6):1414-23. doi: 10.1002/jcb.24483.   PDF

2012
  1. Nguyen CH, Zhao P, Sobiesiak AJ, Chidiac P. RGS2 is a component of the cellular stress response. Biochem Biophys Res Commun. 2012 Sep 14;426(1):129-34. doi: 10.1016/j.bbrc.2012.08.050.   PDF

  2. Jones DL, Tuomi JM, Chidiac P. Role of Cholinergic Innervation and RGS2 in Atrial Arrhythmia. Front Physiol. 2012 Jun 29;3:239. doi: 10.3389/fphys.2012.00239.   PDF

  3. Zhang T, Lu X, Li J, Chidiac P, Sims SM, Feng Q. Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia. Basic Res Cardiol. 2012 Mar;107(2):254. doi: 10.1007/s00395-012-0254-8.   PDF

2011
  1. Nunn C, Zhao P, Zou MX, Summers K, Guglielmo CG, Chidiac P. Resistance to age-related, normal body weight gain in RGS2 deficient mice. Cell Signal. 2011 Aug;23(8):1375-86. doi: 10.1016/j.cellsig.2011.03.020.   PDF

2010
  1. Nunn C, Zou MX, Sobiesiak AJ, Roy AA, Kirshenbaum LA, Chidiac P. RGS2 inhibits beta-adrenergic receptor-induced cardiomyocyte hypertrophy. Cell Signal. 2010 Aug;22(8):1231-9. doi: 10.1016/j.cellsig.2010.03.015.   PDF

  2. Zhao P, Nguyen CH, Chidiac P. The proline-rich N-terminal domain of G18 exhibits a novel G protein regulatory function. J Biol Chem. 2010 Mar 19;285(12):9008-17. doi: 10.1074/jbc.M109.057174.   PDF

  3. Tuomi JM, Chidiac P, Jones DL. Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouse. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H554-61. doi: 10.1152/ajpheart.00779.2009.   PDF

2009
  1. Xiang FL, Lu X, Hammoud L, Zhu P, Chidiac P, Robbins J, Feng Q. Cardiomyocyte specific overexpression of human stem cell factor improves cardiac function and survival post myocardial infarction in mice. Circulation. 2009 Sep 22;120(12):1065-74, 9 p following 1074. doi: 10.1161/CIRCULATIONAHA.108.839068.   Full Text

  2. Nguyen CH, Ming H, Zhao P, Hugendubler L, Gros R, Kimball SR, Chidiac P. Translational control by RGS2. J Cell Biol 2009 Sep 7;186(5):755-65. doi: 10.1083/jcb.200811058.   PDF

  3. Aziziyeh AI, Li TT, Pape C, Pampillo M, Chidiac P, Possmayer F, Babwah AV, Bhattacharya M. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. Cell Signal. 2009 Jul;21(7):1207-17. doi: 10.1016/j.cellsig.2009.03.011.   PDF

  4. Hutchison RM, Chidiac P, Leung LS. Hippocampal long-term potentiation is enhanced in urethane-anesthetized RGS2 knockout mice. Hippocampus. 2009 Aug;19(8):687-91. doi: 10.1002/hipo.20582.   PDF

2008
  1. Chidiac P, Hebert TE. Meeting review: advances from the GPCR Retreat. J Recept Signal Transduct Res. 2008;28(1-2):3-14. doi: 10.1080/10799890801941962.   PDF

2007
  1. Wieland T, Lutz S, Chidiac P. Regulators of G protein signalling: a spotlight on emerging functions in the cardiovascular system. Curr Opin Pharmacol. 2007 Apr;7(2):201-7.   PDF

2006
  1. Roy AA, Nunn C, Ming H, Zou MX, Penninger J, Kirshenbaum LA, Dixon SJ, Chidiac P. Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts. J Biol Chem. 2006 Oct 27;281(43):32684-93.   PDF

  2. Abramow-Newerly M, Ming H, Chidiac P. Modulation of subfamily B/R4 RGS protein function by 14-3-3 proteins. Cell Signal. 2006 Dec;18(12):2209-22.   PDF

  3. Nunn C, Mao H, Chidiac P, Albert PR. RGS17/RGSZ2 and the RZ/A family of regulators of G-protein signaling. Semin Cell Dev Biol. 2006 Jun;17(3):390-9.   PDF

  4. Zou MX, Roy AA, Zhao Q, Kirshenbaum LA, Karmazyn M, Chidiac P. RGS2 is upregulated by and attenuates the hypertrophic effect of alpha1-adrenergic activation in cultured ventricular myocytes. Cell Signal. 2006 Oct;18(10):1655-63.   PDF

  5. Abramow-Newerly M, Roy AA, Nunn C, Chidiac P. RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins. Cell Signal. 2006 May;18(5):579-91.   PDF

  6. Roy AA, Baragli A, Bernstein LS, Hepler JR, Hebert TE, Chidiac P. RGS2 interacts with Gs and adenylyl cyclase in living cells. Cell Signal. 2006 Mar;18(3):336-48.   PDF

2005
  1. Hepler JR, Cladman W, Ramineni S, Hollinger S, Chidiac P. Novel activity of RGS14 on Goalpha and Gialpha nucleotide binding and hydrolysis distinct from its RGS domain and GDI activity. Biochemistry. 2005 Apr 12;44(14):5495-502.   PDF

  2. Gan XT, Rajapurohitam V, Haist JV, Chidiac P, Cook MA, Karmazyn M. Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes. J Pharmacol Exp Ther. 2005 Jan;312(1):27-34.   PDF

  3. Twiner MJ, Chidiac P, Dixon SJ, Trick CG. Extracellular organic compounds from the ichthyotoxic red tide alga Heterosigma akashiwo elevate cytosolic calcium and induce apoptosis in Sf9 cells. Harmful Algae 4. 2005. 789?00.   PDF

2004
  1. Mao H, Zhao Q, Daigle M, Ghahremani MH, Chidiac P, Albert PR. RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling. J Biol Chem. 2004 Jun 18;279(25):26314-22.   PDF

  2. Bernstein LS, Ramineni S, Hague C, Cladman W, Chidiac P, Levey AI, Hepler JR. RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling. J Biol Chem. 2004 May 14;279(20):21248-56.   PDF

2003
  1. Roy AA, Lemberg KE, Chidiac P. Recruitment of RGS2 and RGS4 to the plasma membrane by G proteins and receptors reflects functional interactions. Mol Pharmacol. 2003 Sep;64(3):587-93.   PDF

  2. Chidiac P, Roy AA. Activity, regulation, and intracellular localization of RGS proteins. Receptors Channels. 2003;9(3):135-47.   PDF

  3. Chakraborty C, Barbin YP, Chakrabarti S, Chidiac P, Dixon SJ, Lala PK. Endothelin-1 promotes migration and induces elevation of [Ca2+]i and phosphorylation of MAP kinase of a human extravillous trophoblast cell line. Mol Cell Endocrinol. 2003 Mar 28;201(1-2):63-73.   PDF

2002
  1. Cladman W, Chidiac P. Characterization and comparison of RGS2 and RGS4 as GTPase-activating proteins for m2 muscarinic receptor-stimulated G(i). Mol Pharmacol. 2002 Sep;62(3):654-9.   PDF

  2. Chidiac P, Gadd ME, Hepler JR. Measuring RGS protein interactions with Gq alpha. Methods Enzymol. 2002;344:686-702.   PDF

  3. Chidiac P. Considerations in the evaluation of inverse agonism and protean agonism at G protein-coupled receptors. Methods Enzymol. 2002;343:3-16.   PDF

2001
  1. Santhanagopal A, Chidiac P, Horne WC, Baron R, Dixon SJ. Calcitonin (CT) rapidly increases NA(+)/H(+) exchange and metabolic acid production: effects mediated selectively by the C1A CT receptor isoform. Endocrinology. 2001 Oct;142(10):4401-13.   PDF

2000
  1. Scheschonka A, Dessauer CW, Sinnarajah S, Chidiac P, Shi CS, Kehrl JH. RGS3 is a GTPase-activating protein for g(ialpha) and g(qalpha) and a potent inhibitor of signaling by GTPase-deficient forms of g(qalpha) and g(11alpha). Mol Pharmacol. 2000 Oct;58(4):719-28.   PDF

1999
  1. Chidiac P, Markin VS, Ross EM. Kinetic control of guanine nucleotide binding to soluble Galpha(q). Biochem Pharmacol. 1999 Jul 1;58(1):39-48.   PDF

  2. Chidiac P, Ross EM. Phospholipase C-beta1 directly accelerates GTP hydrolysis by Galphaq and acceleration is inhibited by Gbeta gamma subunits. J Biol Chem. 1999 Jul 9;274(28):19639-43.   PDF

1998
  1. Zeng W, Xu X, Popov S, Mukhopadhyay S, Chidiac P, Swistok J, Danho W, Yagaloff KA, Fisher SL, Ross EM, Muallem S, Wilkie TM. The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling. J Biol Chem. 1998 Dec 25;273(52):34687-90.   PDF

  2. Ingi T, Krumins AM, Chidiac P, Brothers GM, Chung S, Snow BE, Barnes CA, Lanahan AA, Siderovski DP, Ross EM, Gilman AG, Worley PF. Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity. J Neurosci. 1998 Sep 15;18(18):7178-88.   PDF

  3. Chidiac P. Rethinking receptor-G protein-effector interactions. Biochem Pharmacol. 1998 Mar 1;55(5):549-56.   PDF

1997
  1. Green MA, Chidiac P, Wells JW. Cardiac muscarinic receptors. Relationship between the G protein and multiple states of affinity. Biochemistry. 1997 Jun 17;36(24):7380-94.   PDF

  2. Chidiac P, Green MA, Pawagi AB, Wells JW. Cardiac muscarinic receptors. Cooperativity as the basis for multiple states of affinity. Biochemistry. 1997 Jun 17;36(24):7361-79.   PDF

  3. Rousseau G, Guilbault N, Da Silva A, Mouillac B, Chidiac P, Bouvier M. Influence of receptor density on the patterns of beta2-adrenocepter desensitization. Eur J Pharmacol. 1997 May 12;326(1):75-84.   PDF

1996
  1. Chidiac P, Nouet S, Bouvier M. Agonist-induced modulation of inverse agonist efficacy at the beta 2-adrenergic receptor. Mol Pharmacol. 1996 Sep;50(3):662-9.   PDF

  2. Yoshikawa T, Port JD, Asano K, Chidiak P, Bouvier M, Dutcher D, Roden RL, Minobe W, Tremmel KD, Bristow MR. Cardiac adrenergic receptor effects of carvedilol. Eur Heart J. 1996 Apr;17 Suppl B:8-16.   PDF

1995
  1. Labrecque J, Fargin A, Bouvier M, Chidiac P, Dennis M. Serotonergic antagonists differentially inhibit spontaneous activity and decrease ligand binding capacity of the rat 5-hydroxytryptamine type 2C receptor in Sf9 cells. Mol Pharmacol. 1995 Jul;48(1):150-9.   PDF

  2. Chidiac P. Receptor state and ligand efficacy. Trends Pharmacol Sci. 1995 Mar;16(3):83-5.   PDF

  3. Bouvier M, Moffett S, Loisel TP, Mouillac B, Hebert T, Chidiac P. Palmitoylation of G-protein-coupled receptors: a dynamic modification with functional consequences. Biochem Soc Trans. 1995 Feb;23(1):116-20.   PDF

  4. Bouvier M, Chidiac P, Hebert TE, Loisel TP, Moffett S, Mouillac B. Dynamic palmitoylation of G-protein-coupled receptors in eukaryotic cells. Methods Enzymol. 1995;250:300-14.   PDF

1994
  1. St-Onge S, Chidiac P, Brakier-Gingras L, Bouvier M. Beta-adrenergic receptor desensitization in the early stage of hereditary cardiomyopathy in hamsters. Can J Physiol Pharmacol. 1994 Aug;72(8):875-83.  

  2. Chidiac P, Hebert TE, Valiquette M, Dennis M, Bouvier M. Inverse agonist activity of beta-adrenergic antagonists. Mol Pharmacol. 1994 Mar;45(3):490-9.   PDF

1992
  1. Chidiac P, Wells JW. Effects of adenyl nucleotides and carbachol on cooperative interactions among G proteins. Biochemistry. 1992 Nov 10;31(44):10908-21.   PDF

1991
  1. Chidiac P, Nagy A, Sole MJ, Wells JW. Inefficient muscarinic transduction in cardiomyopathic Syrian hamsters. J Mol Cell Cardiol. 1991 Nov;23(11):1255-69.   PDF

1987
  1. Chidiac P, Goldberg MT. Lack of induction of nuclear aberrations by captan in mouse duodenum. Environ Mutagen. 1987;9(3):297-306.  

1986
  1. Goldberg MT, Chidiac P. An in vivo assay for small intestine genotoxicity. Mutat Res. 1986 Aug;164(4):209-15.   PDF