Welcome to the DeKoter Lab

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Welcome to the Homepage of the DeKoter Lab

The goal of our research is to identify genetic causes of diseases affecting the immune system, including primary immunodeficiency and leukemia. These diseases can be caused by mutation of genes encoding transcription factors. We are particularly interested in highly related transcription factors of the E26 transformation-specific (ETS) family called PU.1, Spi-B, and Spi-C. These proteins play diverse roles in regulating development and function of B lymphocytes and myeloid cells. We use a variety of methods to perform these studies including genetically modified mouse models, primary cell culture, chromatin immunoprecipitation, and gene expression analysis. Please follow the links to learn more about our current research activities.

Our research team currently includes three graduate students, a postdoctoral fellow, and a research technician. Our laboratory regularly accepts undergraduates as summer students, honors thesis students, or scholars elective students. We are funded by operating grants from the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada.

News

Congratulations to Sophie and Jess on winning CIHR and NSERC CGS-M awards!

Welcome to Devanshi, a summer volunteer in the lab.

Congratulations to Lauren on winning a CAAIF/Allergen to support work on allergy and asthma research! Lauren will work with Dr. Lisa Cameron for these studies. Link to press release

Recent publications

Solomon LA et al., Coordination of myeloid differentiation with reduced cell cycle progression by PU.1 induction of microRNAs targeting cell cycle regulators and lipid metabolism. Mol. Cell. Biol. pii:e00013-17, 2017. Link

Batista et al., PU.1 regulates Ig light chain transcription and rearrangement in pre-B cells during B cell development. J. Immunol., 198(4):1565-1574, 2017. Link

Current projects

We work on proteins called transcription factors and their role in gene regulation during B cell and macrophage development. Transcription factors such as PU.1, Spi-B, and Spi-C play roles in immune development and in diseases such as immune deficiency. Click here to learn more!

Twitter @rdekoter