Welcome to the DeKoter Lab

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Welcome to the Homepage of the DeKoter Lab

The goal of our research is to identify genetic causes of diseases affecting the immune system, including primary immunodeficiency and leukemia. These diseases can be caused by mutation of genes encoding transcription factors. We are particularly interested in highly related transcription factors of the E26 transformation-specific (ETS) family called PU.1, Spi-B, and Spi-C. These proteins play diverse roles in regulating development and function of B lymphocytes and myeloid cells. We use a variety of methods to perform these studies including genetically modified mouse models, primary cell culture, chromatin immunoprecipitation, and gene expression analysis. Please follow the links to learn more about our current research activities.

Our research team currently includes three graduate students, a postdoctoral fellow, and a research technician. Our laboratory regularly accepts undergraduates as summer students, honors thesis students, or scholars elective students. We are funded by operating grants from the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada.

News

We're recruiting a postdoctoral scholar for a project on B cell leukemia. Please email Rodney DeKoter to ask for more information.

Congratulations to Carolina on winning the top PhD poster prize at the Canadian Society for Immunology Meeting on June 3!

Western recently hosted the 2018 Canadian Society for Immunology Meeting (June 1-4). Check out the YouTube Video!

Recent publications

Batista et al., Deletion of genes encoding PU.1 and Spi-B leads to B cell acute lymphoblastic leukemia associated with driver mutations in Janus Kinases. Published as a preprint on BioRxiv. Link

Solomon LA et al., Lenalidomide modulates gene expression in human ABC-DLBCL cells by regulating IKAROS interaction with an intronic control region of SPIB. Exp. Hematol. 56:46-57, 2017. Link

Current projects

We work on proteins called transcription factors and their role in gene regulation during B cell and macrophage development. Transcription factors such as PU.1, Spi-B, and Spi-C play roles in immune development and in diseases such as immune deficiency. Click here to learn more!

Twitter @rdekoter