Publications
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Research
S. Chakrabarti, MBBS India, FRCP(C); Ph.D., U of Manitoba
Dr. S. Chakrabarti, Department of Pathology, DSB 4011, UWO
Our research focuses on chronic diabetic complications.Hyperglycemia is the key initiating factor in the pathogenesis of chronic diabetic complications. Several secondary and tertiary biochemical mechanisms may be triggered as a result of sustained hyperglycemia. These mechanisms may in turn modulate several proteins which may be of importance in chronic diabetic complications. We are investigating pathogenetic mechanisms of several of these chronic diabetic complications. Diabetic retinopathy and cardiomyopathy are two major areas of research in our laboratory.
Current projects involve analyses of epigenetic mechanisms such as histone acetylation, microRNA alteration and their relationship with alterations of vasoactive factors and extracellular matrix protein production. We further correlate these changes with functional and structural alteration in the organs affected by chronic diabetic complications such as retina, kidney and heart in an attempt to develop potential therapies. We investigate cells, animals with diabetes and human tissues using a wide variety of techniques.
We are also involved in a multi-disciplinary research group studying various aspects of heart failure, its causes, pathogenesis and treatment as diabetes is one of the major causes of heart failure. We are also part of Ontario ginseng innovation and research consortium (OGIRC),where we are investigating preventive effects of ginseng on chronic diabetic complications.
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