Translational Ovarian Cancer Research Program

Trevor G. Shepherd and Mark W. Nachtigal (2008) Constitutively-active bone morphogenetic protein receptor signalling reduces ovarian cancer cell adhesion and intraperitoneal tumour formation. Manuscript to be submitted .

Trevor G. Shepherd , Brigitte L. Theriault and Mark W. Nachtigal (2008) Autocrine BMP4 signalling regulates ID3 proto -oncogene expression in human ovarian cancer cells. Gene, in press.

Natasza A. Kurpios, Lesley MacNeil, Trevor G. Shepherd and John A. Hassell (2008) The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland development. Submitted to Developmental Biology .

Brigitte L. Theriault, Trevor G. Shepherd , Michelle L. Mujoomdar and Mark W. Nachtigal (2007) BMP4 signalling induces EMT and promotes the aggressive phenotype of human ovarian cancer cells. Carcinogenesis 28 : 1153-62.

Trevor G. Shepherd , Brigitte L. Theriault, Elizabeth Campbell & Mark W. Nachtigal (2006) Primary culture of ovarian surface epithelial cells and ascites-derived ovarian cancer cells from patients. Nat Protocols 1 : 2643-9.

Yangxin Fu, Laura M. O'Connor, Trevor G. Shepherd , Mark W. Nachtigal (2003) The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor ß (TGFß) induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun , 310 : 391-7 .

Trevor G. Shepherd and Mark W. Nachtigal (2003) Identification of a putative autocrine bone morphogenetic protein (BMP) signaling pathway in human ovarian surface epithelium (OSE) and ovarian cancer (OC) cells. Endocrinology 144 : 3306-14.

Yangxin Fu, Elizabeth J. Campbell Dwyer, Trevor G. Shepherd and Mark W. Nachtigal (2003) Promoter hypermethylation and histone deacetylation contribute to reduced PACE4 gene expression in human ovarian cancer cells. Molec Cancer Res 1 : 569-76.

Natasza A. Kurpios, Nancy Sabolic, Trevor G. Shepherd , Gina Fidalgo and John A. Hassell (2003) Function of PEA3 ets transcription factors in mammary gland development and oncogenesis. J Mammary Gland Biol Neoplasia . 8 : 177-90.

Lesley D. Dunfield, Trevor G. Shepherd and Mark W. Nachtigal (2002) Primary culture and mRNA analysis of human ovarian cells. Biol Proced Online 4 : 55-61.

Trevor G. Shepherd , Lisa Kockeritz, Michelle R. Szrajber, William J. Muller and John A. Hassell (2001) The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis. Curr Biol 11 : 1739-1748.

Trevor Shepherd and John A. Hassell (2001) Role of Ets transcription factors in mammary gland development and oncogenesis. J Mam Gland Biol Neoplasia 6 : 129-140.

Nelson K. S. Khoo, John F. Bechberger, Trevor Shepherd , Shari L. Bond, Keith R. McCrae, G. Scot Hamilton, and Peeyush K. Lala (1998) SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. I. Mechanisms responsible for hyperinvasiveness and resistance to anti-invasive action of TGFbeta. Int J Cancer 77 : 429-39.