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* Zhong, R., Tucker, J., Zhang, Z., Wall, W., Grant, D., Quan, D., Garcia, B., Gao, Z.H., Asfar, S., Sharpe, M., et al. 2003. The long-term survival of baboon-to-monkey kidney and liver xenografts. Xenotransplantation 10:398-409.

* Zhong, R., Luo, Y., Yang, H., Garcia, B., Ghanekar, A., Luke, P., Chakrabarti, S., Lajoie, G., Phillips, M.J., Katopodis, A.G., et al. 2003. Improvement in human decay accelerating factor transgenic porcine kidney xenograft rejection with intravenous administration of gas914, a polymeric form of alphaGAL. Transplantation 75:10-19.

* Wang, H., Hosiawa, K.A., Min, W., Yang, J., Zhang, X., Garcia, B., Ichim, T.E., Zhou, D., Lian, D., Kelvin, D.J., et al. 2003. Cytokines regulate the pattern of rejection and susceptibility to cyclosporine therapy in different mouse recipient strains after cardiac allografting. J Immunol 171:3823-3836.

* Wang, H., Hosiawa, K.A., Garcia, B., Shum, J.B., Dutartre, P., Kelvin, D.J., and Zhong, R. 2003. Treatment with a short course of LF 15-0195 and continuous cyclosporin A attenuates acute xenograft rejection in a rat-to-mouse cardiac transplantation model. Xenotransplantation 10:325-336.

* Wang, H., Hosiawa, K.A., Garcia, B., Shum, J.B., Dutartre, P., Kelvin, D.J., and Zhong, R. 2003. Attenuation of acute xenograft rejection by short-term treatment with LF15-0195 and monoclonal antibody against CD45RB in a rat-to-mouse cardiac transplantation model. Transplantation 75:1475-1481.

* Yang, H., Chen, G., Kanai, N., Shum, J., Garcia, B., Huang, X., Min, W., Luo, Y., Dutartre, P., and Zhong, R. 2003. Monotherapy with LF 15-0195, an analogue of 15-deoxyspergualin, significantly prolongs renal allograft survival in monkeys. Transplantation 75:1166-1171.

* Bedard, E.L., Kim, P., Jiang, J., Parry, N., Liu, L., Wang, H., Garcia, B., Li, X., McFadden, G., Lucas, A., et al. 2003. Chemokine-binding viral protein M-T7 prevents chronic rejection in rat renal allografts. Transplantation 76:249-252.

* Luo, Y., Levy, G., Garcia, B.M., Yang, H., Phillips, J., Noble, L., Chakrabarti, S., Grant, D., and Zhong, R. 2003. Ex vivo and extracorporeal perfusion with hDAF pig kidneys. Xenotransplantation 10:410-421.

* Min, W.P., Zhou, D., Ichim, T.E., Xia, X., Zhang, X., Yang, J., Huang, X., Garcia, B., Dutartre, P., Jevnikar, A.M., et al. 2003. Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells. Transplantation 75:1160-1165.

* Min, W.P., Zhou, D., Ichim, T.E., Strejan, G.H., Xia, X., Yang, J., Huang, X., Garcia, B., White, D., Dutartre, P., et al. 2003. Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J Immunol 170:1304-1312.

* Zhou, D., O'Brien, C., Shum, J., Garcia, B., Min, W., Jevnikar, A.M., Dutartre, P., and Zhong, R. 2003. LF 15-0195, a novel immunosuppressive agent prevents rejection and induces operational tolerance in a mouse cardiac allograft model. Transplantation 76:644-650.

* Ghanekar, A., Lajoie, G., Luo, Y., Yang, H., Choi, J., Garcia, B., Cole, E.H., Greig, P.D., Cattral, M.S., Phillips, M.J., et al. 2002. Improvement in rejection of human decay accelerating factor transgenic pig-to-primate renal xenografts with administration of rabbit antithymocyte serum. Transplantation 74:28-35.

* Kellersmann, R., Lazarovits, A., Grant, D., Garcia, B., Chan, B., Kellersmann, A., Wang, H., Jevnikar, A., Wagner, N., Muller, W., et al. 2002. Monoclonal antibody against beta7 integrins, but not beta7 deficiency, attenuates intestinal allograft rejection in mice. Transplantation 74:1327-1334.

* Luo, Y., Levy, G., Ding, J., Qi, J., Chakbrati, S., Garcia, B.M., Phillips, M.J., Kumar, N., Friend, P., Noble, L., et al. 2002. HDAF transgenic pig livers are protected from hyperacute rejection during ex vivo perfusion with human blood. Xenotransplantation 9:36-44.

* Ghanekar, A., Luo, Y., Yang, H., Garcia, B., Luke, P., Chakrabarti, S., Lajoie, G., Phillips, M.J., Katopodis, A., Cattral, M.S., et al. 2001. The alpha-Gal analog GAS914 ameliorates delayed rejection of hDAF transgenic pig-to-baboon renal xenografts. Transplant Proc 33:3853-3854.

* Ghanekar, A., Lajoie, G., Luo, Y., Yang, H., Choi, J., Garcia, B., Greig, P.D., Cattral, M.S., Cole, E.H., Phillips, M.J., et al. 2001. Treatment with rabbit antithymocyte serum permits a cyclophosphamide-free approach to prevention of hDAF transgenic porcine kidney xenograft rejection in baboons. Transplant Proc 33:3849-3850.

* Kellersmann, R., Zhong, R., Garcia, B., Gao, Z.H., Kellersmann, A., Kiyochi, H., and Grant, D.R. 2001. A short course of high-dose cyclophosphamide induces long-term survival of intestinal allografts in mice. Transpl Int 14:261-265.

* Deng, D.X., Jiang, J., Garcia, B., Zhong, R., and Chakrabarti, S. 2000. Endothelin-1, endothelin-3 and their receptors (endothelin(A) and endothelin(B)) in chronic renal transplant rejection in rats. Transpl Int 13:175-182.

* Gao, Z.H., Lazarovits, A.I., Wang, J., Xing, J., Garcia, B., Kellersmann, R., Kelvin, D., and Zhong, R. 2000. Allograft tolerance induced by cyclophosphamide without prior inoculation of donor cells--immune suppression and redirection. Transpl Immunol 8:65-73.

* Kellersman, R., Zhong, R., Kiyochi, H., Garcia, B., and Grant, D.R. 2000. Reconstruction of the intestinal lymphatic drainage after small bowel transplantation. Transplantation 69:10-16.

* Kellersmann, R., Zhong, R., Grant, D., Garcia, B., Blomer, A., Liu, W., Wagner, N., Muller, W., Jevnikar, A., Thiede, A., et al. 2000. Despite high levels of lymphocyte homing receptor alpha4beta7 integrin after small bowel allotransplantation, it is not critical for rejection. Transplant Proc 32:1267-1268.

* Kiyochi, H., Zhang, Z., Jiang, J., Wang, H., Garcia, B., Kellersmann, R., Blomer, A., Zhong, R., and Grant, D. 2000. Histologic comparison of small bowel, heart, and kidney xenografts in a rat to mouse model. Transplant Proc 32:964.

* Wang, H., DeVries, M.E., Deng, S., Khandaker, M.H., Pickering, J.G., Chow, L.H., Garcia, B., Kelvin, D.J., and Zhong, R. 2000. The axis of interleukin 12 and gamma interferon regulates acute vascular xenogeneic rejection. Nat Med 6:549-555.

* Zhang, Z., Lazarovits, A., Gao, Z., Garcia, B., Jiang, J., Wang, J., Xing, J.J., White, M., and Zhong, R. 2000. Prolongation of xenograft survival using monoclonal antibody CD45RB and cyclophosphamide in rat-to-mouse kidney and heart transplant models. Transplantation 69:1137-1146.

* Gao, Z., Zhong, R., Jiang, J., Garcia, B., Xing, J.J., White, M.J., and Lazarovits, A.I. 1999. Adoptively transferable tolerance induced by CD45RB monoclonal antibody. J Am Soc Nephrol 10:374-381.

* Kiyochi, H., Kellersmann, R., Blomer, A., Garcia, B.M., Zhang, Z., Zhong, R., and Grant, D.R. 1999. Rat-to-mouse small bowel xenotransplantation: a novel model for studying acute vascular and hyperacute xenograft rejection and xenogenic cell migration. Xenotransplantation 6:28-35.

* Kiyochi, H., Kellersmann, R., Blomer, A., Garcia, B., Zhang, Z., Zhong, R., and Grant, D. 1999. Pathology and cell migration in a novel rat-to-mouse small bowel xenotransplant model. Transplant Proc 31:587.

* Parry, N., Lazarovits, A.I., Wang, J., Garcia, B., Luke, P., Poppema, S., and Zhong, R. 1999. Cyclosporine inhibits long-term survival in cardiac allografts treated with monoclonal antibody against CD45RB. J Heart Lung Transplant 18:441-447.

* Wang, H., Rollins, S.A., Gao, Z., Garcia, B., Zhang, Z., Xing, J., Li, L., Kellersmann, R., Matis, L.A., and Zhong, R. 1999. Complement inhibition with an anti-C5 monoclonal antibody prevents hyperacute rejection in a xenograft heart transplantation model. Transplantation 68:1643-1651.

* Cagiannos, C., Zhong, R., Zang, Z., Jiang, J., Garcia, B.M., Chakrabarti, S., Jevnikar, A.M., Sinclair, N.R., and Grant, D.R. 1998. Effect of major histocompatibility complex expression on murine intestinal graft survival. Transplantation 66:1369-1374.

* Chan, B.M., Zheng, H., Wang, H., Uniyal, S., Garcia, B., Wang, J., and Zhong, R. 1998. Treatment of cardiac allografts with established leukocyte infiltration by modulation of alpha4 (CD49d) and leukocyte function-associated antigen-1 (CD11a/CD18) integrin function. Transplantation 66:277-283.

* Kellersmann, R., Zhong, R., Gao, Z.H., Garcia, B., Zhang, Z., Kiyochi, H., Xing, J.J., and Grant, D. 1998. Beneficial effects of microsurgical lymphatic reconstruction after intestinal transplantation in rats. Transplant Proc 30:2642.

* Kiyochi, H., Grant, D., Zhang, Z., Garcia, B., Kellersmann, R., Wang, H., and Zhong, R. 1998. Rat-to-mouse small bowel xenotransplantation: novel models to study hyperacute and acute humoral rejection. Transplant Proc 30:2589.

Dept. Pathology at UWO

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Dept. Pathology at LHSC