Interacting Protein | Function(s) | PubMed Link(s) | Protein Link | E1A Region(s) of Interaction |
AP-2 | helix-span-helix transcription factor | A | A | interacts with N-terminus |
ATF-1 | bZIP transcription factor | A, B | A | interacts with CR3 zinc finger motif |
ATF-2 | bZIP transcription factor | A, B, C | A | interacts with CR3 zinc finger motif |
ATF-3 | bZIP transcription factor | A, B | A | interacts with CR3 zinc finger motif |
BS69 | repressor of transactivation | A, B | A | interacts with CR2 and CR3 |
CBF | CCAAT-box-binding transcription factor | A | A | interacts with CR3 |
CBP | transcriptional co-activator histone acetyltransferase |
A, B | A | interacts with N-terminus and CR1 |
c-Jun | bZIP transcription factor | A, B | A | interacts with CR3 |
CtBP | transcriptional repressor | A | A | interacts with C-terminal PLDLS motif |
dnaK | E.coli chaperone protein | A | A | Not Known |
Dr1 | negative regulator of TBP | A | A | interacts with N-terminus |
Dyrk1 | dual-specificity kinase | A | A | interacts with C-terminus |
E12 | bHLH transcription factor | A | A | interacts with N-terminus and CR1 |
Hsp70 | chaperone protein | A | A | co-localizes with E1A in the nucleus, not shown to interact directly |
Myogenin | myogenic regulator bHLH transcription factor |
A | A | interacts with N-terminus and CR1 |
Necdin | neuron-specific growth supressor | A | A | interacts with exon 1 |
p21(CIP1/WAF1) | cyclin dependent kinase inhibitor | A | A | interacts with N-terminus and CR1 |
p27 (Kip1) | cyclin dependent kinase inhibitor | A | A | Not Known |
p107 | cell cycle regulator transcriptional modulator |
A | A | interacts with CR1 and CR2 |
p130 | cell cycle regulator transcriptional modulator |
A, B, C | A | interacts with CR1 and CR2 |
p202 | interferon activated gene | A | A | interacts with CR2 |
p300 | transcriptional co-activator histone acetyltransferase |
A | A | interacts with N-terminus and CR1 |
p400 | SWI2/SNF2-related protein | A | A | interacts with N-terminus and CR1 |
p/CAF | transcriptional regulator histone acetyltransferase |
A, B, C | A | interacts with N-terminus and CR3 |
RIIalpha | regulatory subunit of PKA | A | A | interacts with N-terminus of Ad12 E1A |
RACK1 | receptor for activated protein kinase C | A | A | Not Known |
RAN | GTPase | A | A | interacts with first 29 amino acids of E1A |
RAP30 | component of TFIIF | A | A | interacts with first 29 amino acids of E1A |
RAR beta | nuclear hormone receptor transcription factor |
A | A | interacts with C-terminus of CR3 (within residues 151-191) |
RB | cell cycle regulator tumor suppressor transcriptional modulator |
A, B, C, D | A | interacts primarily with LXCXE motif in CR2, interaction with CR1 contributes to a lesser extent |
S4 | component of 26S proteosome | A | A | interacts with N-terminus |
Smad1,2,3 | transcription factors activated by TGF-beta | A | 1, 2, 3 | Not Known |
Sp1 | zinc-finger transcription factor | A | A | interacts with CR3 |
Sug1/S8 | transcription factor, component of 26S proteosome |
A, B | A | interacts with N-terminus |
Sur-2/mediator | subunit of SRB/mediator complex | A | A | interacts with CR3 (zinc finger) |
TAF(II)110 | TBP associated factor | A, B | A | interacts with CR3 |
TAF(II)135 | TBP associated factor | A | A | interacts with CR3 |
TAF(II)250 | TBP associated factor | A | A | interacts with CR3 |
TBP | TATA box binding protein | A, B, C, D | A | interacts with the N-terminus (residues 1-29) and the zinc-finger region (within residues 147-177) |
TR | Thyroid hormone receptor | A, B | A | interacts with N-terminus and CR3 |
TRRAP | ATM-related protein | A, B | A | interacts with CR2 (within residues 76-140) |
UBC9 | ubiquitin-conjugating enzyme | A | A | interacts with CR2 (within residues 76-140) |
USF | bHLH transcription factor | A | A | interacts with CR3 |
YY1 | zinc finger transcription factor | A, B | A | interacts with N-terminus and CR3 |