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Laboratory and Facilities :::
Laboratories located in the
Medical Sciences Building of the University of Western Ontario
Currently applying single
cell, systems, behavioral, imaging and computational techniques to the study of
neuronal oscillations, hippocampal and limbic physiology and models of
epilepsy.
Single cell recordings include whole-cell recordings in vitro
and intracellular recordings in vivo.
Systems recordings include extracellular recordings of field
potentials and units and computational models. Analytical techniques include
current source density analysis of field potentials, power spectral and
coherence analysis.
Behavioral models include acute drug-induced models of
schizophrenia. Behavioral tests include prepulse inhibition, spatial mazes and
open field behaviors.
Compartment computational models to explain generation and significance of neuronal
oscillations in the hippocampus
Functional magnetic resonance
imaging of the brain of animals (at
Robarts’ Research Institute)
Epilepsy models including kindling, kainic
acid and pilocarpine induced status epilepticus, immature seizures induced by hyperthermia
and GABA-B receptor antagonist.