::: Representative publications :::

Leung LS, Luo T, Ma J, Herrick I. (2014) Brain areas that influence general anesthesia. Progress in Neurobiology 122:24-44.

Tai, SK, Ma J, Leung LS (2014) Medial septal cholinergic neurons modulate isoflurane anesthesia. Anesthesiology 120(2):392-402.

Ma J and Leung LS (2014) Deep brain stimulation of the medial septum or nucleus accumbens alleviates psychosis-relevant behavior in ketamine-treated rats. Behav Brain Res 266C:174-182

Leung LS, Ma J, Shen B, Nachim I, Luo T (2013) Medial septal lesion enhances general anesthesia response. Exp Neurology 247:419-428.

Boyce R and Leung LS (2013) Loss of dendritic inhibition in the hippocampus after repeated early-life hyperthermic seizures in rats. Epilepsy Research, 103(1):62-72.

Ma J, Tai, SK, Leung LS (2012) Septohippocampal GABAergic neurons mediate the altered behaviors induced by N-methyl-D-aspartate receptor antagonists. Hippocampus 22(12):2208-18.

Tsai ML, Crutchley MC, Boyce R, Ma J, Boon F, Cain DP, Leung LS (2012) Long-lasting auditory gating deficit accompanied by GABAB receptor dysfunction in the hippocampus after early-life limbic seizures in rats. Physiology & Behavior 106(4):534-41.

Tai, SK and Leung LS (2012) Vestibular stimulation enhances hippocampal long-term potentiation via activation of cholinergic septohippocampal cells. Behav Brain Res 232(1):174-82.

Hutchison RM, Womelsdorf T, Gati JS, Leung LS, Menon RS, Everling S (2012) Resting-state connectivity identifies four primary functional networks in macaque cingulate cortex. Cerebral Cortex 22(6):1294-308.

Tai SK and Leung LS (2012) Activation of the hippocampus by cholinergic septohippocampal neurons during vestibular stimulation. Hippocampus 22(4):914-25.

Leung LS (2011) Intracellular theta phase precession generated by intrinsic subthreshold membrane currents. J Neuroscience 31(34):12282-96. PDF

Ma J and Leung LS (2011) Hippocampal GABAB receptor blockade affects sensory and sensorimotor gating in Long-Evans rats. Pyschopharmacology 217(2):167-76.

Luo T and Leung LS (2011) Involvement of tuberomammillary histaminergic neurons in isoflurane anesthesia. Anesthesiology 115(1):36-43. PDF

Hutchison RM, Leung LS, Mirsattari SM, Gati JS, Menon R, Everling S (2011) Functional networks in the macaque brain revealed by independent component analysis of resting-state fMRI. Neuroimage 56(3):1546-55.

Leung LS, Petropoulos S, Shen B, Luo T, Herrick I, Rajakumar, Ma J (2011) Lesion of cholinergic basal forebrain neurons enhances the response to general anesthetics. Exp Neurol 228: 259–269. PDF

Fung TK, Peloquin P, Wu K, Leung LS (2011) Differential long-term depression in CA3 but not in dentate gyrus following low-frequency stimulation of the medial perforant path. Synapse 65(7):677-86.

Womelsdorf T, Vinck M, Leung LS, Everling S (2010) Selective theta-synchronization of choice-relevant information subserves goal-directed behavior. Frontiers Human Neurosci 4:210.

Luo T and Leung LS (2010) Endogenous histamine facilitates long-term potentiation in the hippocampus during walking. J Neuroscience 30:7845-7852. PDF

Hutchison RM, Mirsattari SM, Jones CK, Gati JS, Leung LS (2010) Functional networks in the anesthetized rat brain revealed by independent component analysis of resting-state fMRI. J Neurophysiology 103:3398-3406. PDF

Ma J, Boyce R, Leung LS (2010) Nucleus accumbens mu opioid receptors mediate postictal depression after an amygdaloid kindled seizure in rats. Epilepsy and Behavior 17(2):165-171.

Qu L, Boyce R, Leung LS (2010) Seizures in the developing brain result in a long-lasting decrease in GABAB inhibitory postsynaptic potential in the rat hippocampus. Neurobiol Dis 37(3):704-710. PDF

Leung LS and Peloquin P (2010) Cholinergic modulation differs between basal and apical dendritic excitation of hippocampal CA1 pyramidal cells. Cerebral Cortex 20(8): 1865-1877.

Luo T and Leung LS (2009) Basal Forebrain histaminergic transmission modulates electroencephalographic activity and emergence from isoflurane anesthesia. Anesthesiology 111:725-733.

Ma J and Leung LS (2009) Kindled seizure in the prefrontal cortex activated behavioral hyperactivity and increase in accumbens gamma oscillations through the hippocampus. Behav Brain Res 206(1):68-77.

Leung LS (2009) Kindling, long-term potentiation and spatial memory performance. Can J Neurol Sci 36 Suppl 2:S36-8.

Ma J, Tai SK, Leung LS (2009)  Ketamine-induced deficit of auditory gating in the hippocampus of rats is alleviated by medial septal inactivation and antipsychotic drugs. Psychopharmacology 206:457-67.

Long JL, Shen B, Luo T, Stewart L, McMurran TJA, Leung LS (2009) Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. Exp Neurology 219(1):308-18. PDF

Qu L and Leung LS (2009) Effects of hyperthermia on neuronal inhibition in hippocampal neurons of immature and mature rats, J Neuroscience Research 87(12):2773-2785.

Long JL, Ma J, Leung LS (2009). Behavioral depression induced by an amygdala seizure and the opioid fentanyl was mediated through the nucleus accumbens. Epilepsia 50(8):1953-61.

Hutchison RM, Chidiac P, Leung LS (2009) Hippocampal long-term potentiation is enhanced in urethane-anesthetized RGS2 knockout mice, Hippocampus 19(8):687-91.

Qu L and Leung LS (2008) Mechanisms of hyperthermia-induced depression of GABAergic synaptic transmission in the immature rat hippocampus. J Neurochemistry 106(5): 2158–2169. PDF

Dorlap S and Leung LS (2008). Cholinergic modulation of hippocampal CA1 basal-dendritic long-term potentiation. Neurobiology of learning and memory 90(2): 382–388.

Tsai ML, Shen B, Leung LS (2008) Seizures induced by GABAB receptor blockade in early-life induced long-term GABAB receptor hypofunction and kindling facilitation. Epilepsy Res 79: 187- 200.

Leung LS, Canning KJ, Peloquin P (2008) Paired-pulse depression of excitatory postsynaptic current sinks in hippocampal CA1 in vivo. Hippocampus 18(10):1008-1020.

Mirsattari SM, Shen B, Leung LS, Rajakumar N (2008) A gliotoxin model of occipital seizures in rats.  Seizure 17(6):483-489.

Qu L, Liu X, Wu C, Leung LS (2007) Hyperthermia decreases GABAergic synaptic transmission in hippocampal neurons of immature rats. Neurobiology of Disease 27: 320–327

Mirsattari SM, Ives JR, Leung LS, Menon RS (2007) EEG monitoring during functional magnetic resonance imaging in animal models. Epilepsia 48(Suppl. 4): 37–46.

Leung LS and Shen B (2007). GABAB receptor blockade induced gamma rhythm and state-dependent theta rhythm in the hippocampus of behaving rats. Hippocampus 17(4): 281-91.

Ma J and Leung LS (2007) The supramammillo-septal-hippocampal pathway mediates sensorimotor gating impairment and hyperlocomotion induced by MK-801 and ketamine. Psychopharmacology (Berl) 191(4): 961-74.

Leung LS, Wu K (2006) Epilepsy-based changes in hippocampal excitability: cause or effect?  In “Intractable Epilepsies”, Blume WT et al. (Ed.), Lippincott, Adv Neurol 97: 63-68.PDF

Leung LS and Shen B (2006) Hippocampal partial kindling decreased hippocampal GABA-B receptor efficacy and wet dog shakes in behaving rats. Behavioral Brain Research 173 (2): 274-281.

Leung LS and Peloquin P (2006) GABAB receptors inhibit backpropagating dendritic spikes in hippocampal CA1 pyramidal cells in vivo.  Hippocampus 16(4): 388-407.

Poon N, Kloosterman F, Wu C, Leung LS (2006) Presynaptic GABAB receptors on glutamatergic terminals of CA1 pyramidal cells decrease in efficacy after partial hippocampal kindling. Synapse 59(3):125-34. PDF

Leung LS and Shen B (2006). Hippocampal CA1 kindling but not long-term potentiation disrupts spatial performance. Learning and Memory 13:18-26. PDF

Tsai ML and Leung LS (2006) Decrease of hippocampal GABAB-receptor mediated inhibition after hyperthermia-induced seizures in immature rats. Epilepsia 47(2):277-287. PDF

Ma J and Leung LS. (2006)  Limbic system participates in mediating the effects of general anesthetics. Neuropsychopharmacology 31(6):1177-92.  PDF

Stewart L and Leung LS (2005) Hippocampal melatonin receptors modulate seizure threshold. Epilepsia 46(4): 473-480. PDF

Leung LS, Canning KJ and Shen B (2005) Hippocampal afterdischarges after GABAB receptor blockade in the behaving rat.  Epilepsia 46(2):203-216. PDF

Liu XH and Leung LS (2004) Sodium-activated potassium conductance participates in the depolarizing afterpotential following a single action potential in rat hippocampal CA1 pyramidal cells. Brain Res 103: 185-192.  PDF

Ma J, Shen B, Rajakumar N, Leung LS (2004). The medial septum mediates impairment of prepulse inhibition of acoustic startle induced by a hippocampal seizure or phencyclidine. Behav Brain Res 155: 153-166.  PDF

Leung LS and Shen B (2004) Glutamatergic synaptic transmission participates in generating the hippocampal EEG. Hippocampus 4: 510 - 525.  PDF

Ma J and Leung LS (2004) Schizophrenia-like behavioral changes after partial hippocampal kindling. Brain Research 997: 111-118. PDF  

Leung LS, Shen B, Ma J, Rajakumar N (2003) Cholinergic activity enhances hippocampal long-term potentiation during walking in rats. J Neurosci 23: 9297-9304. PDF

Liu XH and Leung LS (2003) Partial hippocampal kindling increases GABAB receptor-mediated postsynaptic currents in CA1 pyramidal cells.  Epilepsy Research 57: 33–47. PDF

Stewart L and Leung LS (2003) Temporal lobe seizures alter the amplitude and timing of behavioral rhythms. Epilepsy & Behavior 4(2):153-60.

Wu K and Leung LS (2003)  Increased dendritic excitability in hippocampal CA1 in vivo in the kainic acid model of temporal lobe epilepsy: a study using current source density analysis”.  Neuroscience 116(2): 599-616. PDF

Leung LS and Wu C (2003)  Kindling suppresses primed-burst induced long-term potentiation in hippocampal CA1.  NeuroReport, 14: 211-214.

Liebregts M, McLachlan RS, Leung LS (2002) Hyperthermia induces age-dependent changes in rat hippocampal excitability. Ann Neurol 52(3): 318-326. PDF

Townsend G, Peloquin P, Kloosterman F, Leung LS (2002) Recording and marking with silicon multichannel electrodes.Brain Res Brain Res Protoc 9(2): 122-129.  PDF

Ma J, Leung LS (2002) Metabotropic glutamate receptors in the hippocampus mediate hippocampal gamma waves and behavioral hyperactvity after a hippocampal seizure. Behav Brain Res 133(1): 45-56. PDF

Ma J, Shen B, Stewart LS, Herrick IA, Leung LS (2002) The septohippocampal system participates in general anesthesia. J Neurosci 22: RC200. PDF

Kloosterman F, Peloquin P, Leung LS (2001). Apical and basal orthodromic population spikes in hippocampal CA1 in vivo show different origins and patterns of propagation. J Neurophysiol 86: 2435-2444. PDF

Wu K, Leung LS (2001) Enhanced but fragile inhibition in the dentate gyrus in vivo in the kainic acid model of temporal lobe epilepsy - a study using current source density analysis. Neuroscience, 104(2): 379-396. PDF


Selected Papers before 2001

Canning KJ, Wu K, Peolquin P, Kloosterman F, Leung LS (2000) Physiology of the entorhinal and perirhinal projections to the hippocampus studied by current source density analysis. Ann NY Acad Sci 911: 55-72.

Leung LS, Ma J, McLachlan RS (2000) Behaviors induced or disrupted by complex partial seizures Neuroscience & Biobehavioral Reviews 24: 763-775. PDF

Leung LS (1998) Generation of theta and gamma rhythms in the hippocampus. Neuroscience & Biobehavioral Reviews 22: 275-290. PDF

Leung LS, Yu H (1998) Theta-frequency resonance in hippocampal CA1 neurons in vitro demonstrated by sinusoidal current injection. Journal of Neurophysiology 79: 1592-1596. PDF

Wu C, Leung LS (1997) Partial hippocampal kindling decreases the efficacy of presynaptic GABAB autoreceptors in CA1. Journal of Neuroscience 17: 9261-9269. PDF

Canning KJ and Leung LS (1997) Lateral entorhinal, perirhinal and amygdala-entorhinal transition projections to hippocampal CA1 and dentate gyrus in the rat: a current source density study. Hippocampus 7: 643-655.

Leung LS, Brzozowski D, Shen B (1996) Partial hippocampal kindling affects retention but not acquisition, and place but not cue task on the radial arm maze. Behavioral Neuroscience 110: 1017-1024.

Ma J, Brudzynski SM, Leung LS (1996) Involvement of the nucleus accumbens-ventral pallidal pathway in postictal behavior induced by a hippocampal afterdischarge in rats. Brain Res 739: 26-35.

Leung LS, Roth L, Canning K (1995) Entorhinal inputs to the hippocampal CA1 and dentate gyrus in the rat: a current-source-density study.  J Neurophysiology 73:2392-2403.

Leung LS and Fu X-W (1994) Factors affecting paired-pulse facilitation in CA1 neurons in vitro.  Brain Research 650: 75-84.

Leung LS and Yim CY (1993) Rhythmic delta activities in the nucleus accumbens of anaesthetized and freely moving rats. Can J Physiology & Pharmacology 71: 311-320.

Kaibara T and Leung LS (1993) Basal versus apical dendritic long-term potentiation in hippocampal CA1: a current-source density study.  J Neuroscience 13: 2391-2404.

Zhao D and Leung LS (1991) Effects of hippocampal kindling on paired-pulse response in CA1 in vitro.  Brain Research 564:220-229.

Leung LWS and Yim CY (1991) Intrinsic membrane potential oscillations in hippocampal neurons in vitro.  Brain Research 553: 261-274.

Leung LS and Borst JGG (1987) Electrical activity in the cingulate cortex of the rat. I. Generating mechanisms and relations to behavior.  Brain Res 407: 68-80.

Leung LWS and Yim CY (1986) Intracellular records of theta rhythm in hippocampal CA1 cells of the rat.  Brain Res 367: 323-327.

Leung LWS (1985) Spectral analysis of hippocampal EEG in the freely moving rat: effects of centrally active drugs and relations to evoked potentials.  Electroenceph clin Neurophysiol 60: 65-77.

Leung LWS (1984) Pharmacology of theta phase shift in the hippocampal CA1 region of freely moving rats.  Electroenceph clin Neurophysiol 58: 457-466.

Leung LWS (1984) Theta rhythm during REM sleep and waking: correlations between power, phase and frequency.  Electroenceph clin Neurophysiol 58: 553-564.

Leung LWS (1984) Model of gradual phase shift of theta rhythm in the rat. J Neurophysiol 52:1051-1065.

Buzsaki G, Leung LWS, Vanderwolf, CH (1983) Cellular bases of hippocampal EEG in the behaving rat.  Brain Res Rev 6: 139-171.

Leung LWS (1982) Nonlinear feedback model of neuronal populations in the hippocampal CA1 region.  J. Neurophysiology 47: 845-868.

Leung LWS, Lopes da Silva FH, Wadman WJ (1982) Spectral characteristics of the hippocampal EEG in the freely moving rat. Electroenceph clin Neurophysiol 54: 203-219.

Leung LS (1980) Behavior-dependent evoked potentials in the hippocampal CA1 region of the rat.  I. Correlation with behavior and EEG.  Brain Res 198: 95-117.

Leung LS, Vanderwolf CH (1980) Behavior-dependent evoked potentials in the hippocampal CA1 region of the rat.  II. Effect of eserine, atropine, ether and pentobarbital.  Brain Res 198: 119-133.

Leung LS (1979) Orthodromic activation of the hippocampal CA1 region in the rat.  Brain Research 176: 49-63.

Leung LWS (1979) Potentials evoked by the alvear tract in hippocampus CA1 of rats.  I. Topographical projection, component analysis, and correlation with unit activities.  J Neurophysiol 42: 1557-70.

Leung LWS (1979) Potentials evoked by the alvear tract in hippocampal CA1 of rats.  II. Spatial field analysis.  J Neurophysiol 42: 1571-1589.


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