Khan Lab, Pathology and Laboratory Medicine
Western University
Created February 2008; Last updated September 17, 2014 [Z.Khan]
Schulich School of Medicine & Dentistry
Western University
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Todorovich SM and Khan ZA. Elevated T-box 2 in infantile hemangioma stem cells maintains an adipogenic differentiation-competent state. Dermatoendocrinol. 5: 352-357, 2013.
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McArthur K, Darling MR, and Khan ZA. Establishing an in vitro model of salivary gland tumors. The Cutting Edge: a publication of the American Association of Pathologists Assistants. In press.
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Kleiman A, Keats EC, Chan NG, and Khan ZA. Elevated IGF2 prevents leptin induction and terminal adipocyte differentiation in hemangioma stem cells. Exp Mol Pathol. 94: 126-36, 2013.
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MacDonald AJ and Khan ZA. Expression of blood-brain barrier-specific antigens in non-brain derived endothelial cells despite lack of astrocyte interactions. Br J Med Med Res 3: 29-40, 2013.
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Chen S, Chakrabarti R, Keats EC, Chen M, Chakrabarti S, Khan ZA. Regulation of vascular endothelial growth factor expression by extra domain B segment of fibronectin in endothelial cells. Invest Ophthalmol Vis Sci. 53(13):8333-43, 2012.
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Welten CM, Keats EC, Ang LC, and Khan ZA. Hemangioblastoma stromal cells show committed stem cell phenotype. Can J Neurol Sci. 39, 821-827, 2012.
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Roach EE, Chakrabarti R. Park NI, Keats EC, Yip J, Chan NG, and Khan ZA. Intrinsic regulation of hemangioma involution by platelet-derived growth factor. Cell Death Dis. 3, e328, 2012.
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Keats E and Khan ZA. Unique responses of stem cell-derived vascular endothelial and mesenchymal cells to high levels of glucose. PLoS ONE 7. e38752, 2012.
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Kleiman A, Keats EC, Chan NG, and Khan ZA. Evolution of hemangioma endothelium. Exp Mol Pathol. 93:264-272, 2012. | |
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Keats EC and Khan ZA. Vascular stem cells in diabetic complications: evidence for a role in the pathogenesis and the therapeutic promise. Cardiovasc Diabetol. 11(1): 37, 201. | |
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Khan ZA and Chakrabarti S. Glucose-induced cellular signalling in diabetic retinopathy. In: Visual Dysfunction in Diabetes: The Science of Patient Impairment and Health Care. Tombran-Tink J, Barnstable CJ, Gardner TW (Eds.). Humana Press. Chapter 13, pp 211-232, 2012.
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Khan ZA and Chakrabarti S. Chronic diabetic complications: endothelial cells at the frontline. In: Frontiers in Cardiovascular Drug Discovery. Choudhary MI, Rahman A (Eds.). Bentham Science Publishers Ltd, 1,121-137, 2010. |
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Khan ZA, Chakrabarti S. Response: Inhibition of p300 and nuclear factor-kappaB by curcumin and its role in diabetic nephropathy. Nutrition. 25: 975-976, 2009.
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Chiu J, Khan ZA, Farhangkhoee H, and Chakrabarti S. Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor κB. Nutrition. 25: 964-972, 2009. |
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Dudley AC, Khan ZA, Shih SC, Kang SY, Zwaans BM, Bischoff J, and Klagsbrun M. Calcification of multipotent prostate tumor endothelium. Cancer Cell. 14: 201-211, 2008.
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Melero-Martin JM, De Obaldia ME, Kang SY, Khan ZA, Yuan L, Oettgen P, and Bischoff J. Engineering vascular networks in vivo with human postnatal progenitor cells isolated from blood and bone marrow. Circ Res. 103: 194-202, 2008.
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Khan ZA, Boscolo E, Picard A, Psutka S, Melero-Martin JM, Bartch TC, Mulliken JB, Bischoff J. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. J Clin Invest. 118: 2592-2599, 2008.
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Picard A, Boscolo E, Khan ZA, Bartch T, Mulliken JB, Vazquez MP, Bischoff J. IGF-2 expression and localization in congenital versus common hemangioma. Ped Res. 63: 263-267, 2008. |
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Khan ZA, Chakrabarti S. Cellular signaling and potential new treatment targets in diabetic retinopathy. Exp Diabetes Res. 2007/31861, 2007.
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Xin X, Chen S, Khan ZA, Chakrabarti S. Akt activation and augmented fibronectin production in hyperhexosemia. Am J Physiol Endcrinol Metab. 293: E1036-E1044, 2007.
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Melero-Martin JM, Khan ZA, Picard A, Wu X, Paruchuri S, Bischoff J. In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Blood. 109: 4761-4768, 2007.
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Chen S, Khan ZA, Karmazyn M, Chakrabarti S. Cardiomyocyte hypertrophy in diabetes: role of vasoactive factors and mitogen activated protein kinase (MAPK) activation. Diabetes Metab Res Rev. 23: 356-367, 2007. |
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Paruchuri S, Yang JH, Rabkin-Aikawa E, Melero Martin JM, Khan ZA, Loukogeorgakis S, Schoen FJ, Bischoff J. Human pulmonary valve progenitor cells exhibit endothelial/ mesenchymal plasticity in response to VEGF-A and TGFβ2. Circ Res. 99: 861-869, 2006.
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Kaur H, Chen S, Xin X, Chiu J, Khan ZA, Chakrabarti S. Diabetes-induced extracellular matrix protein expression is mediated by transcription co-activator p300. Diabetes. 55: 3104-3111, 2006.
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Khan ZA, Melero-Martin JM, Wu X, Paruchuri S, Boscolo E, Mulliken J, Bischoff J. Endothelial progenitor cells from infantile hemangioma and from umbilical cord blood display unique cellular responses to endostatin. Blood. 108: 915-921, 2006.
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Farhangkhoee H, Khan ZA, Karmazyn M, Chakrabarti S. Differential effects of curcumin on vasoactive factors in the diabetic rat heart. Nutr Metab. 3: 27-35, 2006. | |
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Khan ZA, Chakrabarti S. Therapeutic targeting of endothelial dysfunction in chronic diabetic complications. Recent Pat. Cardiovasc. Drug Discovery. 1: 167-175, 2006. | |
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Siddiqui I, Khan ZA, Moussa M, Garcia B, Zhong R, Chakrabarti S. Endothelin-mediated oncofetal fibronectin expression in chronic allograft nephropathy. Transplantation. 82: 406-414, 2006. | |
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Khan ZA, Farhangkhoee H, Chakrabarti S. Endothelins: regulators of extracellular matrix production in diabetes. Exp Biol Med. 231: 1022-1029, 2006. | |
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Khan ZA, Farhangkhoee H, Chakrabarti S. Towards newer molecular targets for chronic diabetic complications. Curr Vasc Pharmacol. 4: 45-57, 2006. | |
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Farhangkhoee H, Khan ZA, Kaur H, Xin X, Chen S, Chakrabarti S. Diabetic cardiomyopathy: pathogenesis and potential treatment targets. Pharmacol Ther. 111: 384-399, 2006. |
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Chakrabarti S, Khan ZA. Endothelins and microvascular endothelial responses in diabetes. In: Microvascular Research: Biology and Pathology. Elsevier Science, 671-676, 2005.
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Khan ZA, Farhangkhoee H, Chan BM, Shashi U, Barbin YP, Chen S, Chakrabarti, S. ED-B fibronectin and angiogenesis – a novel mechanistic pathway. Angiogenesis. 8: 183-196, 2005.
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Khan ZA, Farhangkhoee H, Barbin YP, Adams P, Chakrabarti S. Glucose-mediated expression of novel iron transporters in vascular endothelial cells. Free Radic Res. 39: 1203-1210, 2005.
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Khan ZA, Cuartero J, Chan BM, Uniyal S, Barbin YP, Chakrabarti S. ED-B fibronectin in non-small cell lung carcinoma. Exp Lung Res. 31: 701-711, 2005. | |
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Xin X, Khan ZA, Chen S, Chakrabarti S. Glucose-induced Akt1 phosphorylation mediates fibronectin synthesis in endothelial cells. Diabetologia. 48: 2428-2436, 2005. | |
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Farhangkhoee H, Khan ZA, Barbin YP, and Chakrabarti S. Upregulation of CD36 in diabetes-induced oxidative stress and vascular endothelial cell dysfunction. Diabetologia. 48: 1401-1410, 2005. | |
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Aleryani S, Cluette-Brown JE, Khan ZA, Hasaba H, de Hereda LL, Laposata M. Fatty acid methyl esters are detectable in the plasma and their presence correlates with liver dysfunction. Clinica Chimica Acta. 359: 141-149, 2005.
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Fukuda G, Yoshitake N, Khan ZA, Kanazawa M, Notoya Y, Che XF, Akiyama S, Tomoda A, Chakrabarti S, Odawara M. 2-Amino-phenoxazine-3-one attenuates glucose-induced augmentation of embryonic form of myosin heavy chain, endothelin-1 and plasminogen activator inhibitor-1 in human umbilical vein endothelial cells. Biol Pharm Bull. 28: 797-801, 2005.
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Khan ZA, Barbin YP, Farhangkhoee H, Beier N, Scholz W, Chakrabarti S. Serum- and glucocorticoid-regulated kinase in glucose-induced oncofetal fibronectin expression. Biochem Biophys Res Commun. 329: 275-280, 2005.
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Fukuda G, Khan ZA, Barbin YP, Farhangkhoee H, Tilton RG, Chakrabarti S. Endothelin mediated remodeling in aortas of diabetic rats. Diabetes Metab Res Rev. Rev. 21: 367-375, 2005 |
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Chen S, Khan ZA, Barbin Y, Chakrabarti S. Pro-oxidant role of heme oxygenase in mediating glucose-induced endothelial cell damage. Free Radic Res. 38: 1301-1310, 2004.
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Xin X, Khan ZA, Chen S, Chakrabarti S. Glucose-induced and endothelin-mediated extracellular signal regulated kinase in fibronectin synthesis. Lab Invest. 84: 1451-1459, 2004. | |
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Khan ZA, Babrin YP, Cukiernik M, Adams P, Chakrabarti S. Heme oxygenase-mediated iron accumulation in the liver. Can J Physiol Pharmacol. 82: 448-456, 2004. | |
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Chakrabarti S, Khan ZA, Cukiernik M, Zhang W, Sima AAF. C-peptide in retinal microangiopathy in diabetes. Exp Diabesity Res. 5:1-6, 2004. | |
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Kowluru R, Kowluru A, Chakrabarti S, Khan Z. Potential contributory role of h-ras, a small G-protein, in the development of retinopathy in diabetic rats. Diabetes. 53:775-783, 2004. | |
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Cukiernik M, Hileeto D, Downey D, Evans T, Khan ZA, Karmazyn M, Chakrabarti S. Role of the sodium hydrogen exchanger-1 in mediating diabetes induced changes in the retina. Diabetes Metab Res Rev. 20:61-71, 2004.
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Khan ZA, Cukiernik M, Gonder JR, and Chakrabarti S. Oncofetal fibronectin in diabetic retinopathy. Invest Ophthalmol Vis Sci. 45:287-295, 2004. |
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Khan ZA and Chakrabarti S. Growth factors in proliferative diabetic retinopathy. Exp Diabesity Res. 4:287-301. 2003.
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Farhangkhoee F, Khan ZA, Mukherjee S, Cukiernik M, Barbin YP, Chakrabarti S. Heme oxygenase in diabetes-induced oxidative stress in the heart. J Mol Cell Cardiol, 35:1439-1448, 2003.
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Khan ZA, Chakrabarti S. Endothelins in chronic diabetic complications. Can J Physiol Pharmacol, 81:622-634, 2003. | |
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Adams P, Barbin YP, Khan ZA, Chakrabarti S. Expression of ferroportin in hemochromatosis liver. Blood Cells Mol Dis, 31:256-261, 2003. | |
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Chen S, Khan ZA, Cukiernik M, Chakrabarti S. Differential activation of NF-κB and AP-1 in target organs of diabetic complications. Am J Physiol Endocrinol Metab, 284:E1089-1097, 2003. |
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Chakrabarti S, Khan ZA, Cukiernik M, Fukuda G, Chen S, Mukherjee S. Alteration of endothelins: a common pathogenetic mechanism in chronic diabetic complications. Int J Exp Diabetes Res, 3:217-231, 2002. |
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Keats EC, Dominguez JM, Grant MB, and Khan ZA. Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis. Stem Cells. In press PMID: 24496952
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Kum JJY and Khan ZA. Propranolol inhibits growth of hemangioma-initiating cells but does not induce apoptosis. Pediatr Res. 75: 381-388, 2014.
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