Notes:
| Mutant Designation | Nucleotide Changes | Amino Acid Changes | Reference(s) | Notes on phenotype etc. |
| 2-36 | del 563-667 | del 2-36 | (B. Zerler et al., 1987; R.W. Stein et al., 1990; H. Wang et al., 1991; D. Kalman et al., 1993; D.A. Taylor et al., 1993; I. Kitabayashi et al., 1995; K. Somasundaram et al., 1996) | does not repress transcription, transform with ras, inhibit PC12 differentiation, induce c-jun expression or induce mitosis, impaired for induction of DNA synthesis, does not bind p300, AP-2, or myogenin or induce p300 phosphorylation |
| 9S | del 638-1228 | del 29-289 | (E. Moran et al., 1986; H. Wang et al., 1991) | 9S cDNA, "unstable" 55 residue product, spliced into different frame, C-terminal addition of CLNLSLSPSQ NRSLQDLPAV LKWRLLS |
| 10S (30K) | del 638-853, 975-1228 | del 27-98 and 140-186 | (C. Stephens and E. Harlow, 1987; S. Gopalakrishnan et al., 1996) | 10S cDNA, double splice product, host range, CR3 transactivation defective, does not transform with ras or E1B, does not induce p110-GAP complex formation |
| 10S/11S | del 638-853 | del 27-98 | (C. Stephens and E. Harlow, 1987) | expresses only 10S and 11S double splice products, host range, does not transform with ras or E1B |
| 11S (35K) | del 638-853, 1113-1228 | del 27-98 | (C. Stephens and E. Harlow, 1987) | 11S cDNA, host range, does not transform with ras or E1B |
| 12S | del 975-1228 | del 140-186 | (B. Zerler et al., 1986; C. Stephens and E. Harlow, 1987) | 12S cDNA, host range, CR3 transactivation defective |
| 12S:CTdl1339 | termination linker after 1339 | del 222-289 | (M.P. Quinlan et al., 1988) | 12S product only |
| 12S-CTRL22 | ins PIDG at 4 | (H.A. Zieler et al., 1995) | 12S product only | |
| 12S-delta4-22 | del 584-625, ins? | del 4-22, ins SA | (H.A. Zieler et al., 1995) | 12S product only |
| 12S-delta4-22, 121-138 | del 584-625, ins?, del 830-973 | del 4-22, ins SA, del121-128 | (H.A. Zieler et al., 1995) | does not complement web1 or web2 mutants in yeast, 12S product only |
| 12S-delta9-22 | del 584-625 | del 9-22 | (H.A. Zieler et al., 1995) | 12S product only |
| 12S-delta9-22, 121-138 | del 584-625, del 830-973 | del 9-22 and 121-128 | (H.A. Zieler et al., 1995) | does not complement web1 or web2 mutants in yeast, 12S product only |
| 12S-delta23-85 | del 626-814 | del 23-85 | (H.A. Zieler et al., 1995) | does not complement web1 or web2 mutants in yeast, 12S product only |
| 12S-delta86-106 | del 815-877 | del 86-106 | (H.A. Zieler et al., 1995) | 12S product only |
| 12S-delta86-120 | del 815-919 | del 86-120 | (H.A. Zieler et al., 1995) | 12S product only |
| 12S-delta91-138 | del 830-973 | del 91-138 | (H.A. Zieler et al., 1995) | does not complement web2 mutants in yeast, 12S product only |
| 12S-delta121-126 | del 920-937 | del 121-126 | (H.A. Zieler et al., 1995) | 12S product only |
| 12S-delta121-138 | del 920-973 | del 121-138 | (H.A. Zieler et al., 1995) | 12S product only |
| 12S-delta141-176 | del 1234-1341 | del 187-222 | (H.A. Zieler et al., 1995) | 12S product only |
| 12S-delta177-219 | del 1342-1470 | del 223-265, ins SGIP | (H.A. Zieler et al., 1995) | 12S product only |
| 12S:dlA | del 1368-1523 | del 232-283 | (M.P. Quinlan et al., 1988; S. Gopalakrishnan et al., 1996) | 12S product only, does not induce p110-GAP complex formation |
| 12S-PM2,3 | R to A at 2, H to D at 3 | (H.A. Zieler et al., 1995) | 12S product only | |
| 12S-PM2,3,124 | R to A at 2, H to D at 3, C to G at 124 | (H.A. Zieler et al., 1995) | weakly complements web1 mutants in yeast, 12S product only | |
| 12S-TR22 | ins stop codon at 625 | del 23-289 | (H.A. Zieler et al., 1995) | truncated protein, does not complements web1 or web2 mutants in yeast, 12S product only |
| 12S-TR220 | ins stop codon at 1473 | del 267-289 | (H.A. Zieler et al., 1995) | truncated protein, not recognized by M73, 12S product only |
| 13S | del 1113-1228 | none | (B. Zerler et al., 1986; C. Stephens and E. Harlow, 1987) | 13S cDNA, does not transform with E1B |
| 15-35 | del 602-664 | del 15-35 | (R.W. Stein et al., 1990; D.A. Taylor et al., 1993; I. Kitabayashi et al., 1995) | does not repress transcription, transform with ras, induce c-jun expression, bind p300 or myogenin or induce p300 phosphorylation |
| 18-0 | del 613-616, replace with AGCCGAATTC GG | L at 19 replaced with RIR | (T. Subramanian et al., 1988) | defective for transformation with E1B and ras |
| 38-67 | del 38 to 67, ins SSR | (P. Raychaudhuri et al., 1991; H.A. Zieler et al., 1995) | does not free E2F from inhibitory binding proteins or complement web2 mutants in yeast | |
| 47-0 | del 702-705 | D and L at 48 and 49 replaced with V | (M. Kuppuswamy et al., 1988) | defective for immortalization but not transformation with ras |
| 51-116 | del 710-907 | del 51-116 | (R.W. Stein et al., 1990; P. Raychaudhuri et al., 1991; I. Kitabayashi et al., 1995) | does not repress transcription, induce c-jun expression or bind p300, but still transforms with ras, does not free E2F from inhibitory binding proteins or induce p300 phosphorylation |
| 73-120 | del 776-919 | del 73-120 | (R.W. Stein et al., 1990) | |
| 76-120 | del 785-919 | del 76-120 | (R.W. Stein et al., 1990) | |
| 81-120 | del 800-919 | del 81-120 | (R.W. Stein et al., 1990; H.G. Wang et al., 1995) | does not immortalize primary BRK cells |
| 89A | T to G at 824 | S to A at 89 | (D.J. Dumont et al., 1989) | no longer phosphorylated at 89, migrates faster on SDS-PAGE, new Bsp1286I site introduced |
| 120-1 | insert GCCGAATTCG GC after 919 | insert AEFG between 120 and 121 | (M.N. Kuppuswamy and G. Chinnadurai, 1987) | |
| 125-7 | del 935-938 replace with CCGAATTCGG | E at 126 replaced with PDS | (T. Subramanian et al., 1988) | abortive foci with ras |
| 130-3 | del 951-953 | replace P and S at 131 and 132 with R | (M.N. Kuppuswamy and G. Chinnadurai, 1987) | |
| 137ED | E to D at 137 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 138ED | E to D at 138 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 139GA | G to A at 139 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 140ED | E to D at 140 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 140EQ | E to Q at 140 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 141ED | E to D at 141 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 141EQ | E to Q at 141 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 142FY | F to Y at 142 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 143VL | V to L at 143 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 144LI | L to I at 144 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 145DE | D to E at 145 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 145DN | D to N at 145 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation impaired | |
| 146YF | Y to F at 146 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 147VL | V to L at 147 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective | |
| 148ED | E to D at 148 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 148EQ | E to Q at 148 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 149HF | H to F at 149 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 149HY | H to Y at 149 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 150PG | P to G at 150 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation impaired | |
| 150-1 | ins CCGGAATTCCGA after 1009 | ins PEFR between 150 and 151 | (M.N. Kuppuswamy and G. Chinnadurai, 1987) | |
| 151GA | G to A at 151 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 152HF | H to F at 152 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 153GA | G to A at 153 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 154CS | C to S at 149 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, mutation of zinc finger cysteine | |
| 155RK | R to K at 155 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 156ST | S to T at 156 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 157CS | C to S at 157 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, mutation of zinc finger cysteine | |
| 158HF | H to F at 158 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 160HY | H to Y at 160 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation impaired | |
| 161RK | R to K at 161 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 162RK | R to K at 162 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 163NQ | N to Q at 163 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 164TS | T to S at 164 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 165GA | G to A at 165 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 166DE | D to E at 166 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 166DN | D to N at 166 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 167PG | P to G at 167 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 168DE | D to E at 168 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 169IL | I to L at 169 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 170MI | M to I at 170 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 171CS | C to S at 171 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, mutation of zinc finger cysteine | |
| 172ST | S to T at 172 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective | |
| 173LI | L to I at 173 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 173LF | L to F at 173 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation impaired | |
| 174CS | C to S at 174 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, mutation of zinc finger cysteine | |
| 175YF | Y to F at 175 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation impaired | |
| 176-E | ins CTAG at 1343 | 222-289, extra S | (T. Subramanian et al., 1989) | defective for immortalization, enhanced transformation with ras, enhanced metastatic and tumorigenic potential |
| 176ML | M to L at 176 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 176MK | M to K at 176 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective | |
| 176-9 | del 1345-1574, ins AAACGCCTAG GCCTTAA | del 224-284 | (T. Subramanian et al., 1989) | defective for immortalization, enhanced transformation with ras, enhanced metastatic and tumorigenic potential |
| 177RK | R to K at 177 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation impaired | |
| 178TS | T to S at 178 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 179CS | C to S at 179 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 180GA | G to A at 180 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 180GC | G to C at 180 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation impaired | |
| 180GN | G to N at 180 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 180GD | G to D at 180 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, trans-dominant suppressor of wt CR3 mediated activation | |
| 181MI | M to I at 181 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 182FY | F to Y at 182 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 183VL | V to L at 183 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, trans-dominant suppressor of wt CR3 mediated activation | |
| 184YF | Y to F at 184 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation impaired, trans-dominant suppressor of wt CR3 mediated activation | |
| 185SG | S to G at 185 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, trans-dominant suppressor of wt CR3 mediated activation | |
| 185SI | S to I at 185 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, trans-dominant suppressor of wt CR3 mediated activation | |
| 185SN | S to N at 185 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, trans-dominant suppressor of wt CR3 mediated activation | |
| 185SR | S to R at 185 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, trans-dominant suppressor of wt CR3 mediated activation | |
| 185ST | S to T at 185 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, trans-dominant suppressor of wt CR3 mediated activation | |
| 185SY | S to Y at 185 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, trans-dominant suppressor of wt CR3 mediated activation | |
| 186PG | P to G at 186 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, trans-dominant suppressor of wt CR3 mediated activation | |
| 187VL | V to L at 187 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, trans-dominant suppressor of wt CR3 mediated activation | |
| 188ST | S to T at 188 | (L.C. Webster and R.P. Ricciardi, 1991) | CR3 transactivation defective, trans-dominant suppressor of wt CR3 mediated activation | |
| 188+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 188 | none | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 188- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 188 | none | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 188c | ins CGGATC after 188 | none | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 189ED | E to D at 189 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 190PG | P to G at 190 | (L.C. Webster and R.P. Ricciardi, 1991) | ||
| 222-3 | ins GGAATTCC after 1341 | insert REFP between 222 and 223 | (T. Subramanian et al., 1988) | |
| 420+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 420 | none | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 420- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 420 | none | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 420c | ins CGGATC after 420 | none | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 477+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 477 | none | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 477- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 477 | none | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 477c | ins CGGATC after 477 | none | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 548+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 548 | none | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 548- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 548 | none | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 548c | ins CGGATC after 548 | none | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 638R | ins Xba I linker at 638 | del 28-289 | (E.A. Davenport and E.J. Taparowsky, 1990; S.A. Enkemann et al., 1990) | does not transform C3H 10T1/2 cells with ras, or repress troponin I expression in 23A2 myoblasts, introduces new Xba I site, truncated protein |
| 690 | replace 354-689 with 290-626 of Ad12 | del 1-43, ins Ad12 residues | (T. Jelinek and F.L. Graham, 1992; D.S. Pereira et al., 1995) | reduced transformation with E1B, reduced MHC class I expression, hybrid CR1 region |
| 717+ | ins GGATCCAATT GTTATCCGCT CACAATTGGG TCAGGATCC after 717 | ins DPIVIRSQLGQDP between 53 and 54 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, reduced ras transformation |
| 717- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 717 | del 54-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, does not repress the E1A enhancer, does not transform with E1B or ras |
| 717c | ins CGGATC after 717 | ins DP between 53 and 54 | (D.S. Bautista et al., 1991) | introduces new Bam HI site, reduced transformation with E1B |
| 734 | G to A at 734 | E to K at 59 | (J.W. Lillie et al., 1987) | transforms poorly with ras, does not efficiently repress beta-globin expression |
| 741 | C to A at 741 | A to E at 61 | (J.W. Lillie et al., 1987) | does not transform with ras, does not repress beta-globin expression |
| 753 | replace 354-752 with 290-692 of Ad12 | del 1-64, ins Ad12 residues | (T. Jelinek and F.L. Graham, 1992; D.S. Pereira et al., 1995) | reduced transformation with E1B, reduced MHC class I expression, hybrid CR1 region |
| 774 | T to C at 774 | L to S at 72 | (J.W. Lillie et al., 1987) | does not transform with ras, does not repress beta-globin expression |
| 777 | C to T at 777 | A to V at 73 | (J.W. Lillie et al., 1987) | does not transform with ras, does not repress beta-globin expression |
| 812+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 812 | ins DPIVIRSQLG QDP between 85 and 86 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 812- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 812 | del 86-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, does not repress the E1A enhancer, does not transform with E1B or ras |
| 812c | ins CGGATC after 812 | ins DP between 85 and 86 | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 814N | ins Xba I linker at 814 | del 89-289 | (E.A. Davenport and E.J. Taparowsky, 1990; S.A. Enkemann et al., 1990) | does not transform C3H 10T1/2 cells with ras, or repress troponin I expression in 23A2 myoblasts, introduces new Xba I site, truncated protein |
| 819+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 819 | ins GSNCWPLTIG SGS between 87 and 88 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, reduced transformation with E1B |
| 819- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 819 | del 88-289, ins GS | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, does not transform with E1B or ras |
| 819c | ins CGGATC after 819 | ins GS between 87 and 88 | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 827 | replace 354-826 with 290-739 of Ad12 | del 1-90, ins Ad12 residues | (T. Jelinek and F.L. Graham, 1992; D.S. Pereira et al., 1995) | reduced transformation with E1B, reduced MHC class I expression |
| 827+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 827 | ins DPIVIRSQLG QDP between 90 and 91 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, reduced transformation with E1B |
| 827- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 827 | del 91-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, does not repress the E1A enhancer, does not transform with E1B |
| 827c | ins CGGATC after 827 | ins DP between 90 and 91 | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 863+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 863 | ins DPIVIRSQLG QDP between 102 and 103 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 863- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 863 | del 103-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, does not repress the E1A enhancer, does not transform with E1B |
| 863c | ins CGGATC after 863 | ins DP between 102 and 103 | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 882+ | ins GGATCCAATT GTTATCCGCT CACAATTGGG TCAGGATCC after 882 | ins DPIVIRSQLG QDP between 108 and 109 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, reduced transformation with E1B |
| 882- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 882 | del 109-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, does not repress the E1A enhancer, does not transform with E1B or ras |
| 882c | ins CGGATC after 882 | ins DP between 108 and 109 | (D.S. Bautista et al., 1991) | introduces new Bam HI site, reduced transformation with E1B |
| 884+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 884 | ins DPIVIRSQLG QDP between 109 and 110 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, reduced transformation with E1B |
| 884- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 884 | del 110-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, does not repress the E1A enhancer |
| 884c | ins CGGATC after 884 | ins DP between 109 and 110 | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 906+ | ins GGATCCAATT GTTATCCGCT CACAATTGGGT CAGGATCC after 906 | ins DPIVIRSQLG QDP between 116 and 117 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 906- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 906 | del 117-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, does not repress the E1A enhancer, does not transform with E1B or ras |
| 906c | ins CGGATC after 906 | ins DP between 116 and 117 | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 908+ | ins CGGATCCAAT TGTTATCCGCT CACAATTGG GTCAGGATC after 908 | ins DPIVIRSQLG QDP between 117 and 118 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, does not repress the E1A enhancer, transforms poorly with ras |
| 908- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 908 | del 118-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, does not repress the E1A enhancer, does not transform with E1B or ras |
| 908c | ins CGGATC after 908 | ins DP between 117 and 118 | (D.S. Bautista et al., 1991) | introduces new Bam HI site, transforms poorly with ras |
| 917-975 | replace 918-974 with 815-932 of Ad12 | del 122-139, ins Ad12 residues | (T. Jelinek et al., 1994; D.S. Pereira et al., 1995) | transforms poorly with E1B, weak ability to induce tumours in syngeneic rats, reduced MHC class I expression, deletes 12S splice donor site |
| 917-1227 | replace 918-1226 with 815-1142 of Ad12 | del 122-184, ins Ad12 residues | (T. Jelinek et al., 1994; D.S. Pereira et al., 1995) | transforms poorly with E1B, weak but significant ability to induce tumours in syngeneic rats, reduced MHC class I expression, deletes 12S splice donor site |
| 928 | T to G at 929? | C to G at 124 | (E. Moran et al., 1986; B. Zerler et al., 1987; P. Raychaudhuri et al., 1991; H. Wang et al., 1991; D. Kalman et al., 1993) | does not transform or inhibit PC12 differentiation, does not bind pRb, does not induce mitosis efficiently, does not free E2F from inhibitory binding proteins |
| 936 | A to G at 936 | E to G at 126 | (J.W. Lillie et al., 1986) | does not transform with ras, does not repress beta-globin expression |
| 953 | A to G at 953 | S to G at 132 | (J.W. Lillie et al., 1986) | does not transform with ras, does not repress beta-globin expression |
| 961 | G to A at 962? | E to K at 135 | (E. Moran et al., 1986; P. Raychaudhuri et al., 1991) | does not free E2F from inhibitory binding proteins |
| 975 | replace 354-974 with 290-932 of Ad12 | del 1-139, ins Ad12 residues | (T. Jelinek and F.L. Graham, 1992; T. Jelinek et al., 1994; D.S. Pereira et al., 1995) | transforms poorly with E1B, variable ability to induce tumours in syngeneic rats, greatly reduced MHC class I expression, transformed cells not lysed efficiently by allogeneic or syngeneic CTLs, deletes 12S splice donor site |
| 1008+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 1008 | ins GSNCWPLTIG SGS between 150 and 151 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, transforms poorly with E1B, "super" transforms with ras |
| 1008- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 1008 | del 151-289, ins GS | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, does not transform with E1B |
| 1008c | ins CGGATC after 1008 | ins GS between 150 and 151 | (D.S. Bautista et al., 1991) | introduces new Bam HI site, CR3 transactivation defective, host range, does not transform with E1B |
| 1036 | replace 354-1035 with 290-994 of Ad12 | del 1-158, ins Ad12 residues | (T. Jelinek and F.L. Graham, 1992; T. Jelinek et al., 1994; D.S. Pereira et al., 1995) | host range for replication, does not transform with Ad5 E1B, induces tumours in syngeneic rats, greatly reduced MHC class I expression, transformed cells not lysed efficiently by allogeneic or syngeneic CTLs, hybrid CR3 region |
| 1039+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 1039 | ins RIQLLSAHNW VRIR between 160 and 161 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, transforms poorly with E1B, "super" transforms with ras |
| 1039- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 1039 | del 161-289, ins RILTQL | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, does not transform with E1B, "super" transforms with ras |
| 1039c | ins CGGATC after 1039 | ins RI between 160 and 161 | (D.S. Bautista et al., 1991) | introduces new Bam HI site, "super" transforms with ras |
| 1056+ | ins GGATCCAATT GTTATCCGCT CACAATTGGG TCAGGATCC after 1056 | ins DPIVIRSQLG QDP between 166 and 167 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, transforms poorly with E1B, "super" transforms with ras |
| 1056- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 1056 | del 167-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, CR3 transactivation defective, host range, transforms poorly with E1B |
| 1056c | ins CGGATC after 1056 | ins DP between 166 and 167 | (D.S. Bautista et al., 1991) | introduces new Bam HI site, CR3 transactivation defective, host range, transforms poorly with E1B, "super" transforms with ras |
| 1098 | G to A at 1098 | G to D at 180 | (J.W. Lillie et al., 1986) | CR3 transactivation defective |
| 1112 | A to G at 1112 | S to G at 185 | (J.W. Lillie et al., 1986) | CR3 transactivation defective |
| 1227 | replace 354-1226 with 290-1142 of Ad12 | del 1-184, ins Ad12 residues | (T. Jelinek and F.L. Graham, 1992; T. Jelinek et al., 1994; D.S. Pereira et al., 1995) | transforms poorly with E1B, induces tumours in syngeneic rats, greatly reduced MHC class I expression, transformed cells not lysed efficiently by allogeneic or syngeneic CTLs |
| 1267+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 1267 | ins DPIVIRSQLG QDP between 198 and 199 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, does not repress the E1A enhancer efficiently, transforms poorly with E1B |
| 1267- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 1267 | del 199-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, does not repress the E1A enhancer efficiently, transforms poorly with E1B |
| 1267c | ins CGGATC after 1267 | ins DP between 198 and 199 | (D.S. Bautista et al., 1991) | introduces new Bam HI site, does not repress the E1A enhancer |
| 1304+ | ins GGATCCAATT GTTATCCGCT CACAATTGGG TCAGGATCC after 1304 | ins DPIVIRSQLG QDP between 210 and 211 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 1304- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 1304 | del 211-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, transforms poorly with E1B |
| 1304c | ins CGGATC after 1304 | ins DP between 210 and 211 | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 1304N | ins Xba I linker at 1304 | del 213-289 | (E.A. Davenport and E.J. Taparowsky, 1990) | enhanced focus formation with ras in C3H 10T1/2 cells, introduces new Xba I site, truncated protein |
| 1376+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 1376 | ins GSNCWPLTIG SGS between 234 and 235 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 1376- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 1376 | del 235-289, ins GS | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, transforms poorly with E1B |
| 1376c | ins CGGATC after 1376 | ins GS between 234 and 235 | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 1408+ | ins CGGATCCAAT TGTTATCCGC TCACAATTGG GTCAGGATC after 1408 | ins DPIVIRSQLG QDP between 245 and 246 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 1408- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 1408 | del 246-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, transforms poorly with ras |
| 1408c | ins CGGATC after 1408 | ins DP between 245 and 246 | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 1415+ | ins GGATCCAATT GTTATCCGCT CACAATTGGG TCAGGATCC after 1415 | ins DPIVIRSQL GQDP between 247 and 248 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites |
| 1415- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 1415 | del 248-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, transforms poorly with E1B |
| 1415c | ins CGGATC after 1415 | ins DP between 248 and 289 | (D.S. Bautista et al., 1991) | introduces new Bam HI site |
| 1461 | replace 354-1460 with 290-1579 of Ad12 | del 1-261, ins Ad12 residues | (T. Jelinek and F.L. Graham, 1992) | transforms poorly with E1B |
| 1523+ | ins GGATCCAATT GTTATCCGCT CACAATTGGG TCAGGATCC after 1523 | ins DPIVIRSQLG QDP between 283 and 284 | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, slightly impaired for repression of the E1A enhancer |
| 1523- | ins CGGATCCTGA CCCAATTGTG AGCGGATAAC AATTGGATC after 1523 | del 284-289, ins DPDPIVSG | (D.S. Bautista et al., 1991) | introduces two new Bam HI sites, slightly impaired for repression of the E1A enhancer |
| 1523c | ins CGGATC after 1523 | ins DP between 283 and 284 | (D.S. Bautista et al., 1991) | introduces new Bam HI site, slightly impaired for repression of the E1A enhancer |
| Arg240 | R to T at 286 | (J.L. Douglas and M.P. Quinlan, 1996) | not localized exclusively to nucleus, not precipitated by M73 | |
| Arg242 | R to T at 288 | (J.L. Douglas and M.P. Quinlan, 1996) | not precipitated by M73 | |
| CTdl877 | deletion of 877 to 1339, inserted Xba I linker (CTCTAGAG) | del 107-289, ins L | (M.P. Quinlan et al., 1988; P. Whyte et al., 1988) | does not transform with ras, does not induce DNA synthesis |
| CTdl931 | deletion of 931 to 1339, inserted Xba I linker (CTCTAGAG) | del 125-289, ins L | (M.P. Quinlan et al., 1988; P. Whyte et al., 1988; P. Whyte et al., 1989) | does not transform with ras, does not induce DNA synthesis, does not bind pRb or p107 |
| CTdl934 | deletion of 934 to 1339, inserted Xba I linker (CTCTAGAG) | del 126-289, ins L | (M.P. Quinlan et al., 1988; P. Whyte et al., 1988; P. Whyte et al., 1989) | does not transform with ras, does not induce DNA synthesis, does not bind pRb or p107 |
| CTdl940 | deletion of 940 to 1339, inserted Xba I linker (CTCTAGAG) | del 128-289, ins L | (P. Whyte et al., 1988) | transforms poorly with ras |
| CTdl952 | deletion of 952 to 1339, inserted Xba I linker (CTCTAGAG) | del 132-289, ins L | (P. Whyte et al., 1988) | does not transform with ras |
| CTdl961 | deletion of 961 to 1339, inserted Xba I linker (CTCTAGAG) | del 135-289, ins L | (P. Whyte et al., 1988; P. Whyte et al., 1989) | binds pRb poorly |
| CTdl976 | deletion of 976 to 1339, inserted Xba I linker (CTCTAGAG) | del 140-289, ins L | (P. Whyte et al., 1988) | |
| CTdl979 | deletion of 979 to 1339, inserted Xba I linker (CTCTAGAG) | del 141-289, ins L | (P. Whyte et al., 1988) | |
| CTdl1109 | deletion of 1109 to 1339, inserted Xba I linker (CTCTAGAG) | del 151-289, ins L | (P. Whyte et al., 1988) | |
| CXdl | del 921-1007 | del 121-150 | (E. Moran et al., 1986; B. Zerler et al., 1987; B. Moran and B. Zerler, 1988; R.S. Ames et al., 1990; R.W. Stein et al., 1990; H. Wang et al., 1991; D. Kalman et al., 1993) | defective for transformation, CR3 transactivation and inhibition of PC12 differentiation, does not induce sensitivity to TNF, does not bind pRb, does not induce mitosis efficiently, deletes 12S splice site, extra amino acid (A) introduced at deletion site |
| DA21 | D to A at 21 | (H. Wang et al., 1993) | ||
| Del I | 23-150 | (T. Wada et al., 1990) | does not induce a G1 arrest in yeast | |
| Del II | 122-150 | (T. Wada et al., 1990) | ||
| Del III | 223-289, ins 111 residues from GAL7 gene | (T. Wada et al., 1990) | not localized to nucleus in yeast | |
| delta 23-107 | del 626-880 | del 23-107 | (Y. Tsuji et al., 1993) | delayed induction of sensitivity to TNF, does not show augmented sensitivity to TNF in response to IL-1 |
| delta 23-150 | del 626-1009 | del 23-150 | (Y. Tsuji et al., 1993) | does not induce sensitivity to TNF or show augmented sensitivity to TNF in response to IL-1 |
| delta 108-289 | ins Xba I linker (CTCTAGAG) and CTTG at 880 | del 108-289, ins L | (Y. Tsuji et al., 1993) | does not induce sensitivity to TNF or show augmented sensitivity to TNF in response to IL-1 |
| delta 140-146 | del 977-997 | del 140-146 | (J.V. Geisberg et al., 1995) | |
| delta 147-153 | del 998-1018 | del 147-153 | (J.V. Geisberg et al., 1995) | |
| delta 151-289 | ins Xba I linker (CTCTAGAG) at 1009 | del 151-289, ins L | (Y. Tsuji et al., 1993) | does not induce sensitivity to TNF or show augmented sensitivity to TNF in response to IL-1 |
| delta 154-159 | del 1019-1036 | del 154-159 | (J.V. Geisberg et al., 1995) | |
| delta 160-168 | del 1037-1063 | del 160-168 | (J.V. Geisberg et al., 1995) | |
| delta 169-174 | del 1064-1081 | del 169-174 | (J.V. Geisberg et al., 1995) | slight reduction in binding to dTAFII110 and hTAFII250 |
| delta 175-179 | del 1082-1096 | del 175-179 | (J.V. Geisberg et al., 1995) | |
| delta 180-188 | del 1097-1239 | del 180-188 | (L.C. Webster and R.P. Ricciardi, 1991; J.V. Geisberg et al., 1995) | defective for CR3 transactivation, trans-dominant suppressor of wt CR3 mediated activation, binds poorly to dTAFII110 and hTAFII250 |
| delta 223-289 | ins CTAG at 1343 | del 223-289 | (Y. Tsuji et al., 1993) | does not induce sensitivity to TNF or show augmented sensitivity to TNF in response to IL-1 |
| delta BR | del 1276-1323 | del 201-216 | (L. Zhu et al., 1993) | does not bind DNA |
| delta DL | del 1516-1526, ins ? | del 281-282, ins AS | (U. Schaeper et al., 1995) | does not bind CtBP |
| delta PL | del 1510-1515, ins ? | del 279-280, ins AS | (U. Schaeper et al., 1995) | does not bind CtBP |
| delta SC | del 1522-1527, ins ? | del 283-284, ins AS | (U. Schaeper et al., 1995) | does not bind CtBP efficiently |
| DL1 | del 141-182, ins AGSG | (M.L. Fahnestock and J.B. Lewis, 1989) | CR3 transactivation defective | |
| DL2 | del 110-135, ins GSG | (M.L. Fahnestock and J.B. Lewis, 1989) | ||
| dl181-193 | del 1354-1392 | del 227-239 | (J.M. Boyd et al., 1993) | improved transformation with ras, |
| dl310 | del 1324-1350 | del 217-225 | (N. Jones and T. Shenk, 1979; D. Urbanelli et al., 1989) | Xba I site at 1339 destroyed |
| dl311 | del 1282 to 1339 | del 203-289 | (N. Jones and T. Shenk, 1979; D. Urbanelli et al., 1989) | frame shift, host range, does not induce CTL response |
| dl312 | del 448-1349 | del 1-289 | (N. Jones and T. Shenk, 1979; G. Winberg and T. Shenk, 1984) | no E1A protein |
| dl313 | del 1334-3639 | del 220-289 | (N. Jones and T. Shenk, 1979; W.W. Colby and T. Shenk, 1981) | host range, not precipitated with M73 |
| dl314 | del about 430bp starting around 1009 | (N. Jones and T. Shenk, 1979) | host range, Xba I site at 1339 and Hpa I site at 1574 destroyed | |
| dl343 | del 621-622 | del 21-289 | (P. Hearing and T. Shenk, 1985) | frame shift, truncated protein |
| dl344 | del 861-883 | del 100-289 | (P. Hearing and T. Shenk, 1985) | frame shift, truncated protein |
| dl345 | del 858-906 | del 100-289 | (P. Hearing and T. Shenk, 1985) | frame shift, truncated protein |
| dl346 | del 859-906 | del 101-116 | (P. Hearing and T. Shenk, 1985; D. Yu et al., 1990) | does not repress neu expression |
| dl347 | del 975-1228 | del 140-186 | (G. Winberg and T. Shenk, 1984) | 12S cDNA only |
| dl348 | del 1113-1228 | none | (G. Winberg and T. Shenk, 1984) | no 12S product |
| dl520 (JOAC) | del 1107-1117 | del 140-186 | (K.P. Haley et al., 1984; J.F. Schneider et al., 1987) | no 13S mRNA, cold sensitive transformation with E1B, host range growth |
| dl521 (D1/D2) | del 920-1139 | del 29-289 | (K.P. Haley et al., 1984) | 9S mRNA only, predicted 55 residue product, spliced into different frame, C-terminal addition of CLNLSLSPSQ NRSLQDLPAV LKWRLLS |
| dl522 (dl3) | del 1001-1071 | del 148-289, ins 42 mis-sense residues | (K.P. Haley et al., 1984) | normal 12S, truncated 13S mRNA |
| dl526 (G5/3, mCR1) | del 672-752, ins CCTCGATCGA GG | del 38-65, ins SSIEV | (J.F. Schneider et al., 1987; R. Offringa et al., 1990; T. Braun et al., 1992) | does not repress polyoma enhancer, down-modulate AP-1 or Myf-5 activity, immortalize or transform with ras |
| dl527 (GNC) | del 814-918 | del 86-120 | (J.F. Schneider et al., 1987) | |
| dl528 (GCX) | del 921-932, A to T at 933 | del 121-125, ins V | (J.F. Schneider et al., 1987) | impaired for repression of polyoma enhancer, does not immortalize or transform with ras |
| dl529 (G3/2, mCR2) | del 936-959, A to T at 933 | del 125-133, ins L | (J.F. Schneider et al., 1987; T. Braun et al., 1992) | impaired for repression of polyoma enhancer and for inhibition of Myf-5 activity, does not immortalize or transform with ras |
| dl530 (pMX) | insert 8 bp Xho I linker and CT after 1109, T to G at 975 | del 185-289, ins SRLQSCV | (J.F. Schneider et al., 1987; C.K. Krantz et al., 1996) | defective for CR3 transactivation, does not immortalize or induce susceptibility to lysis by NK cells, 13S product only |
| dl637N | deletion of 638 to 812, inserted Xho I linker | del 27-85, ins PRG | (P. Whyte et al., 1989; P.J. Duerksen-Hughes et al., 1991) | does not transform with ras or induce sensitivity to TNF, does not bind p300 or pRb |
| dl646N | deletion of 647 to 812, inserted Xho I linker | del 30-85, ins PRG | (P. Whyte et al., 1989; P.J. Duerksen-Hughes et al., 1991; M.J. Gutch and N.C. Reich, 1991; K.E. Boulukos and E.B. Ziff, 1993; M. Caruso et al., 1993; R. Eckner et al., 1994) | does not transform with ras, repress IFN stimulated gene expression, induce sensitivity to TNF, block differentiation in C2 myoblasts or PC12 cells, does not bind p300 or pRb |
| dl739N | deletion of 740 to 812, inserted Xho I linker | del 61-85, ins PRG | (P. Whyte et al., 1989) | does not transform with ras, does not bind p300 |
| dl742N | deletion of 743 to 812, inserted Xho I linker | del 62-85, ins PRG | (P. Whyte et al., 1989) | does not transform with ras, does not bind p300 |
| dl763N | deletion of 764 to 812, inserted Xho I linker | del 69-85, ins PRG | (P. Whyte et al., 1989) | abortive transformation with ras, does not bind p300 |
| dl787N | deletion of 788 to 812, inserted Xho I linker | del 77-85, ins PRG | (P. Whyte et al., 1989) | |
| dl793N | deletion of 794 to 812, inserted Xho I linker | del 79-85, ins PRG | (P. Whyte et al., 1989) | |
| dl799N | deletion of 800 to 812, inserted Xho I linker | del 81-85, ins PRG | (P. Whyte et al., 1989) | |
| dl805N | deletion of 806 to 812, inserted Xho I linker | del 83-85, ins PRG | (P. Whyte et al., 1989) | |
| dl811N | deletion of 812, inserted Xho I linker | del 85, ins PRG | (P. Whyte et al., 1989) | |
| dl813/919 | deletion of 814-918 | del 86-120 | (P. Whyte et al., 1988) | |
| dl891/1339 | deletion of 892 to 1338, inserted Xba I linker (CTCTAGAG) | del 111-221 | (P. Whyte et al., 1988; D.H. Kim et al., 1997) | does not transform with ras, does not induce p110-GAP complex formation |
| dl922/947 | deletion of 923 to 946, inserted Xba I linker (CTCTAGAG) | del 122-129 | (P. Whyte et al., 1989; C. Missero et al., 1991; M. Caruso et al., 1993; R. Sanchez Prieto et al., 1995) | does not bind pRb or p107, slightly impaired for induction of resistance to TGF-beta, does not block MyoD transcriptional activation function in C3H 10T1/2 cells or induce sensitivity to cisplatin or radiation, confers enhanced sensitivity to doxorubicin |
| dl975/1339 | deletion of 976 to 1338, inserted Xba I linker (CTCTAGAG) | del 139-221 | (P. Whyte et al., 1988) | does not transform with ras |
| dl1101 | del 569-634 | del 4-25 | (C. Egan et al., 1988; T.N. Jelsma et al., 1988; D. Caporossi and S. Bacchetti, 1990; R.W. Gedrich et al., 1992; J.S. Mymryk et al., 1992; M.E. Miller et al., 1995; R.S. Slack et al., 1995; J.M. Routes et al., 1996) | does not transform with ras, induce mitosis, repress SV40 transcription, block myogenic differentiation, induce differentiation in P19 cells, induce cytogenetic damage or induce c-fos expression in synergy with cAMP, does not block IFN stimulated gene expression or cytolytic resistance or induce a G1 growth arrest in yeast, does not bind p400 or p300 |
| dl1102 | del 635-664 | del 26-35 | (T.N. Jelsma et al., 1988) | does not bind p400, otherwise appears wt |
| dl1103 | del 647-706 | del 30-49 | (C. Egan et al., 1988; T.N. Jelsma et al., 1988; R.W. Gedrich et al., 1992; J.S. Mymryk et al., 1992; M.E. Miller et al., 1995) | does not transform with ras, induce mitosis, repress SV40 transcription, block myogenic differentiation, reduced ability to induce c-fos expression in synergy with cAMP and to induce a G1 growth arrest in yeast, does not bind p400 or p300 |
| dl1104 | del 701-739 | del 48-60 | (C. Egan et al., 1988; T.N. Jelsma et al., 1988; R.W. Gedrich et al., 1992; J.S. Mymryk et al., 1992; M.E. Miller et al., 1995; R.S. Slack et al., 1995; J.M. Routes et al., 1996) | does not transform with ras, induce mitosis, repress SV40 transcription, block myogenic differentiation, induce differentiation in P19 cells or induce c-fos expression in synergy with cAMP, does not block IFN stimulated gene expression or cytolytic resistance or induce a G1 growth arrest in yeast, does not bind p300 |
| dl1105 | del 767-802 | del 70-81 | (T.N. Jelsma et al., 1988; R.W. Gedrich et al., 1992) | reduced ability to induce c-fos expression in synergy with cAMP, otherwise appears wt |
| dl1106 | del 827-874 | del 90-105 | (T.N. Jelsma et al., 1988) | appears wt |
| dl1107 | del 890-928 | del 111-123 | (C. Egan et al., 1988; T.N. Jelsma et al., 1988) | transformation defective, mitosis defective, does not bind pRb or p130 |
| dl1108 | del 929-940 | del 124-127 | (C. Egan et al., 1988; T.N. Jelsma et al., 1988) | transformation defective, mitosis defective, induces DNA over-replication, does not bind pRb, p107 or p130 |
| dl1109 | del 941-973 | del 128-138 | (T.N. Jelsma et al., 1988) | mitosis defective, induces DNA over-replication, binds pRb poorly, appears to be less stable than wt |
| dl1110 | del 976-1038 | del 140-160 | (T.N. Jelsma et al., 1988; D. Caporossi and S. Bacchetti, 1990) | CR3 transactivation defective, no 12S product, does not induce cytogenetic damage |
| dl1112 | del 1040-1063 | del 161-168 | (T.N. Jelsma et al., 1988; D. Caporossi and S. Bacchetti, 1990) | CR3 transactivation defective, does not induce cytogenetic damage |
| dl1113 | del 1064-1090 | del 169-177 | (T.N. Jelsma et al., 1988; D. Caporossi and S. Bacchetti, 1990) | CR3 transactivation defective, does not induce cytogenetic damage |
| dl1114 | del 1091-1111 | del 178-184 | (T.N. Jelsma et al., 1988; D. Caporossi and S. Bacchetti, 1990) | CR3 transactivation defective, does not induce cytogenetic damage |
| dl1115 | del 1237-1287 | del 188-204 | (T.N. Jelsma et al., 1988; D. Caporossi and S. Bacchetti, 1990) | CR3 transactivation defective, does not induce cytogenetic damage |
| dl1116 | del 1288-1338 | del 205-221 | (T.N. Jelsma et al., 1988; D. Caporossi and S. Bacchetti, 1990) | impaired for induction of cytogenetic damage |
| dl1119 | del 569-973 | del 4-138 | (T.N. Jelsma et al., 1988) | exon 1 deleted |
| dl1132 | del 1345-1389 | del 224-238 | (J.S. Mymryk and S.T. Bayley, 1993) | |
| dl1133 | del 1396-1437 | del 241-254 | (J.M. Boyd et al., 1993) | immortalizes poorly, enhanced tumorigenicity and metastasis |
| dl1134 | del 1438-1485 | del 255-270 | (J.M. Boyd et al., 1993) | immortalizes poorly, enhanced tumorigenicity and metastasis |
| dl1135 | del 1486-1527 | del 271-284 | (H. Arsenault and J.M. Weber, 1993; J.M. Boyd et al., 1993; U. Schaeper et al., 1995) | does not bind CtBP, immortalizes very poorly, enhanced tumorigenicity, enhanced metastasis, not recognized by M73 |
| dl1136 | del 1527-1542 | del 285-289 | (H. Arsenault and J.M. Weber, 1993; J.M. Boyd et al., 1993) | deletes nuclear localization sequence KRPRP, immortalizes very poorly, enhanced tumorigenicity, enhanced metastasis, not recognized by M73 |
| dl1141 | del 740-766 | del 61-69 | (J.A. Howe et al., 1990; R.W. Gedrich et al., 1992; J.S. Mymryk et al., 1992; R.S. Slack et al., 1995) | does not repress SV40 enhancer, block myogenic differentiation, induce differentiation in P19 cells or induce c-fos expression in synergy with cAMP, does not bind p300 |
| dl1142 | del 803-835 | del 82-92 | (J.A. Howe et al., 1990) | |
| dl1143 | del 671-739 | del 38-60 | (J.A. Howe et al., 1990; J. Shisler et al., 1996) | does not induce DNA synthesis or sensitivity to TNF |
| dl1151 | del 1008-1574 | del 151-289 | (J.S. Mymryk et al., 1992) | exon 2 and most of CR3 deleted, 6 extra amino acids added on C-terminus (TPLFAE) |
| dl1500 | del 1110-1118 | del 140-186 | (C. Montell et al., 1984) | no 13S mRNA, cold sensitive transformation, CR3 transactivation defective |
| dl1501 | del 455-460, ins GGAATTCC | none | (T.F. Osborne et al., 1982) | new Eco RI site |
| dl1502 | 455-475, ins GGAATTCC | none | (T.F. Osborne et al., 1982) | deletes TATA box, new Eco RI site |
| dl1503 | 455-519, ins GGAATTCC | none | (T.F. Osborne et al., 1982) | deletes TATA box and major cap site, new Eco RI site |
| dl1504 | 455-561, ins GGAATTCC | del 1 -14 | (T.F. Osborne et al., 1982; J.F. Downey et al., 1984; C. Egan et al., 1988) | deletes TATA box, major cap site and lacks normal initiation codon, translation initiates at next M, does not bind p300, new Eco RI site |
| E1A-mut CBP | del 749-763 | del 64-68 | (A.J. Bannister and T. Kouzarides, 1995) | does not bind CBP |
| E1A-mut RB | del 814-918 | del 38-44, ins A | (A.J. Bannister and T. Kouzarides, 1995) | does not bind RB |
| EV55 | E to V at 55 | (H. Wang et al., 1993) | ||
| in317 | ins about 360 bp at 1339 | (N. Jones and T. Shenk, 1979) | Xba I site at 1339 destroyed, somewhat host range | |
| F.S. | ins G after 985 | del 143-289, ins 46 missense residues | (L.C. Webster and R.P. Ricciardi, 1991) | frame shift, defective for CR3 transactivation |
| G3NX | del 64-86, ins SSAR | (J.F. Schneider et al., 1987) | does not immortalize, impaired transformation with ras, impaired repression of polyoma enhancer | |
| GCE-R | del 223-289, ins S | (J.F. Schneider et al., 1987) | ||
| GXmA | del 152-182 | (J.F. Schneider et al., 1987) | CR3 transactivation defective | |
| H5sub1101 | del 1-16, ins 1-68 Ad12 | (Y. Sawada et al., 1994) | ||
| H5sub1102 | del 1-185, ins 1-190 Ad12 | (Y. Sawada et al., 1994) | ||
| H5sub1103 | del 1-69 and 140-289, ins 1-68 and 191-266 Ad12 | (Y. Sawada et al., 1994) | does not induce transplantation immunity against group C Adenovirus transformed cells | |
| H5sub1106 | del 69-185, ins 68-190 Ad12 | (Y. Sawada et al., 1994) | ||
| H5sub1107 | del 186-289, ins 191-266 Ad12 | (Y. Sawada et al., 1994) | does not induce transplantation immunity against group C Adenovirus transformed cells | |
| H5sub1108 | del 69-289, ins 68-266 Ad12 | (Y. Sawada et al., 1994) | does not induce transplantation immunity against group C Adenovirus transformed cells | |
| HB dl12 | del 1384-1441, ins GTTA | del 237-256, ins VN | (J.L. Douglas et al., 1991) | enhanced transformation with ras |
| HB dl13 | del 1384-1494, ins GTT | del 237-273, ins V | (J.L. Douglas et al., 1991) | enhanced transformation with ras |
| HB dl14 | del 1384-1527, ins GTTTGT | del 237-284, ins VN | (J.L. Douglas et al., 1991; S. Gopalakrishnan et al., 1996) | enhanced transformation with ras, does not induce p110-GAP complex formation |
| HB dl23 | del 1441-1494 | del 256-273 | (J.L. Douglas et al., 1991) | enhanced transformation with ras |
| HB dl24 | del 1441 to 1527, ins AAC | del 256-284, ins N | (J.L. Douglas et al., 1991; S. Gopalakrishnan et al., 1996) | enhanced transformation with ras, does not induce p110-GAP complex formation |
| HB dl34 | del 1492 to 1527, ins GTTAAC | del 273-284, ins VN | (J.L. Douglas et al., 1991; S. Gopalakrishnan et al., 1996) | enhanced transformation with ras, does not induce p110-GAP complex formation |
| HN3 | H to N at 3 | (H. Wang et al., 1993) | poor viral immortalization of BRK cells, reduced binding to p300, does not repress HIV LTR expression | |
| hr1 | ? | ? | (T. Harrison et al., 1977; D. Caporossi and S. Bacchetti, 1990) | host range growth, CR3 transactivation defective, does not induce cytogenetic damage |
| hr3 | T to A at 1086 | M to K at 176 | (T. Harrison et al., 1977; G.M. Glenn and R.P. Ricciardi, 1985) | host range growth, CR3 transactivation defective |
| hr4 | C to T at 1076 | L to F at 173 | (T. Harrison et al., 1977; G.M. Glenn and R.P. Ricciardi, 1985) | host range growth, CR3 transactivation defective |
| hr5 | G to A at 1229 | S to N at 185 in 289R protein G to D in 243R protein |
(T. Harrison et al., 1977; G.M. Glenn and R.P. Ricciardi, 1985; G.M. Glenn and R.P. Ricciardi, 1987) | host range growth, CR3 transactivation defective, inhibits transactivation by wt CR3 |
| hr440 | del 141-289 | (D. Solnick, 1981; C.K. Krantz et al., 1996) | truncated after residue 140, does not induce susceptibility to lysis by NK cells | |
| LP49 | L to P at 49 | (H. Wang et al., 1993) | ||
| LS1 | del 141-144, ins AGSG | (M.L. Fahnestock and J.B. Lewis, 1989) | impaired CR3 transactivation | |
| LS1T | del 141-289, ins AGSGLCGAPR ARLQVLSLSP EEYGGPRYYV FALLYEDLWH VCL | (M.L. Fahnestock and J.B. Lewis, 1989) | frame shift, defective for CR3 transactivation | |
| LS5 | del 157-160, ins SGSG | (M.L. Fahnestock and J.B. Lewis, 1989) | impaired CR3 transactivation | |
| LS6 | del 162-165, ins SRIR | (M.L. Fahnestock and J.B. Lewis, 1989) | improved CR3 transactivation | |
| LS6A | del 166-168, ins RIR | (M.L. Fahnestock and J.B. Lewis, 1989) | ||
| LS7 | del 168-170, ins GSG | (M.L. Fahnestock and J.B. Lewis, 1989) | reduced CR3 transactivation | |
| LS8 | del 171-174, ins SGSG | (M.L. Fahnestock and J.B. Lewis, 1989) | impaired CR3 transactivation | |
| LS9 | del 175-178, ins SGSG | (M.L. Fahnestock and J.B. Lewis, 1989) | impaired CR3 transactivation | |
| LS10 | del 180-183, ins AGSG | (M.L. Fahnestock and J.B. Lewis, 1989) | defective for CR3 transactivation | |
| LS20 | L to S at 20 | (H. Wang et al., 1993) | reduced viral immortalization of BRK cells, reduced binding to p300 | |
| LTNCT | del 1528-1542, ins CCAAAAAAGA AGAGAAAGGT A | del KRPRP at 285, ins PKKKRKV | (J.L. Douglas and M.P. Quinlan, 1996) | substitution of nuclear localization sequence with that from SV40 LT |
| Lys239 | K to N at 285 | (J.L. Douglas and M.P. Quinlan, 1996) | not localized exclusively to nucleus | |
| NCdl (86-120) | del 814-918 | del 86-120 | (E. Moran et al., 1986; H. Wang et al., 1993; H.G. Wang et al., 1995) | binds p300 and pRb/pRb family members individually but not in the same complex, does not immortalize primary BRK cells |
| NTdl598 | Bal31 digestion to 598, inserted Nco I linker (CCCATGGG) | 2-13 deleted, ins G | (P. Whyte et al., 1988; P. Whyte et al., 1989; C. Missero et al., 1991; R. Sanchez Prieto et al., 1995; S. Gopalakrishnan et al., 1996) | does not transform with ras, induce p110-GAP complex formation or enhance sensitivity to cisplatin or radiation, confers resistance to doxorubicin, impaired for induction of resistance to TGF-beta, does not bind p300 |
| NTdl646 | Bal31 digestion to 646, inserted NcoI linker (CCCATGGG) | 2-29 deleted, ins G | (M.P. Quinlan et al., 1988; P. Whyte et al., 1988; P. Whyte et al., 1989; R. Kaddurah-Daouk et al., 1990; C. Missero et al., 1991; S. Gopalakrishnan et al., 1996) | does not transform with ras, does not induce DNA synthesis, does not bind p300, does not induce p110-GAP complex formation, impaired for induction of resistance to TGF-beta, impaired for induction of brain creating kinase |
| NTdl814 | Bal31 digestion to 814, inserted NcoI linker (CCCATGGG) | 2-85 deleted, ins G | (M.P. Quinlan et al., 1988; P. Whyte et al., 1988; P. Whyte et al., 1989; R. Kaddurah-Daouk et al., 1990; P.J. Duerksen-Hughes et al., 1991; M.J. Gutch and N.C. Reich, 1991; C. Missero et al., 1991) | does not transform with ras, repress IFN stimulated gene expression, does not induce DNA synthesis, sensitivity to TNF, or brain creatine kinase, does not bind p300 or pRb, greatly impaired for induction of resistance to TGF-beta |
| NTdl919 | Bal31 digestion to 919, inserted NcoI linker (CCCATGGG) | 2-120 deleted, ins G | (P. Whyte et al., 1989; P.J. Duerksen-Hughes et al., 1991) | does not induce sensitivity to TNF, does not bind p300 or pRb |
| NTdl1010 | Bal31 digestion to 1010, inserted NcoI linker (CCCATGGG) | 2-150 deleted, ins G | (P. Whyte et al., 1989; P.J. Duerksen-Hughes et al., 1991) | does not induce sensitivity to TNF, bind p300, pRb or p107 |
| pDoff | 8-mer Xba I linker inserted at1247 | substitution of 193-289 with DSSSRALEL | (S. Linder et al., 1992) | enhanced invasion |
| pDroff | 10-mer Xho I linker inserted at1404 | substitution of 246-289 with SRGGPAVPH | (S. Linder et al., 1992) | |
| pD^Dr | substitution of 193-245 with DSSSRA | (S. Linder et al., 1992) | enhanced invasion | |
| pD^X | substitution of 193-221 with DSS | (S. Linder et al., 1992) | ||
| pJF12 (mCR3) | del 975-1228 | del 140-186 | (K.P. Haley et al., 1984) | 12S product only |
| pJN20 | del 1113-1228 | none | (K.P. Haley et al., 1984) | 13S product only |
| pm563 | A to C at 558 A to C at 559 A to G at 563 |
R to G at 2 | (P. Whyte et al., 1988; P. Whyte et al., 1989; M. Caruso et al., 1993; R. Eckner et al., 1994; S. Gopalakrishnan et al., 1996) | does not transform with ras, does not repress MyoD expression in C2 myoblasts, impaired induction of p110-GAP complex formation, no p300 binding, creates NcoI site |
| pm 933 | A to T at 933 | H to L at 125 | (J.F. Schneider et al., 1987) | impaired for immortalization and transformation with ras, new Xho I site introduced |
| pm 957 | A to T at 957 | D to V at 133 | (J.F. Schneider et al., 1987) | impaired for immortalization and transformation with ras, new Sal I site introduced |
| pm 961 | Q to K at 135 | (V.B. Kraus et al., 1992) | ||
| pm 975 | T to G at 975 | (C. Montell et al., 1982) | eliminates 12S splice site, no 12S product | |
| pm 1098 | G to D at 180 | (M.L. Fahnestock and J.B. Lewis, 1989) | specifically impaired for activation of E4 expression by CR3 | |
| pm 1112 | S to G at 185 | (M.L. Fahnestock and J.B. Lewis, 1989) | specifically impaired for activation of E4 expression by CR3 | |
| pm1120 | G to A at 998 G to A at 1000 G to A at 1012 |
V to I at 147 | (T.N. Jelsma et al., 1988) | impaired transactivation by CR3 |
| pm1121 | G to A at 998 G to A at 1000 G to A at 1001 G to A at 1010 G to A at 1012 G to A at 1017 G to A at 1023 G to A at 1029 |
V to I at 147 E to K at 148 G to R at 151 G to D at 153 R to K at 155 C to Y at 157 |
(T.N. Jelsma et al., 1988) | CR3 transactivation defective |
| pm1122 | C to T at 1006 C to T at 1007 C to T at 1008 C to T at 1015 C to T at 1021 |
P to F at 150 | (T.N. Jelsma et al., 1988) | CR3 transactivation defective |
| pm1131 | C to G at 1331 | del 219-289 | (T.N. Jelsma et al., 1988) | stop codon introduced, truncated protein |
| pm DA21 | D to A at 21 | (V.B. Kraus et al., 1992) | ||
| pm HN3 | H to N at 3 | (V.B. Kraus et al., 1992) | ||
| Pro241 | P to A at 287 | (J.L. Douglas and M.P. Quinlan, 1996) | not precipitated by M73 | |
| Pro243 | P to A at 289 | (J.L. Douglas and M.P. Quinlan, 1996) | reduced induction of DNA synthesis, not precipitated by M73 | |
| PSdl | del 625-879 | del 23-107 | (B. Moran and B. Zerler, 1988; R.S. Ames et al., 1990; P.J. Duerksen-Hughes et al., 1991; L.E. Heasley et al., 1991; D. Kalman et al., 1993; J. Shisler et al., 1996) | does not induce DNA synthesis, sensitivity to TNF, transform with ras or inhibit PC12 differentiation |
| pSVF12 | del 975-1228 | del 140-186 | (D.H. Smith et al., 1985; R.W. Stein and E.B. Ziff, 1987) | 12S cDNA only |
| pSVN20 | del 1113-1228 | none | (D.H. Smith et al., 1985; R.W. Stein and E.B. Ziff, 1987) | 13S cDNA only |
| pSVXL3 | del 746-754, ins Xho I linker (CCTCGAGG) | del 64-289, ins SRFFPTL | (D.H. Smith et al., 1985; A. Velcich and E. Ziff, 1985; X. Montano and D.P. Lane, 1987; R.W. Stein and E.B. Ziff, 1987; A. Velcich and E. Ziff, 1988; A. Velcich and E.B. Ziff, 1989) | frame shift, does not transactivate, repress transcription, transform with ras or induce F9 differentiation |
| pSVXL101 | del 1337-1367, ins Xho I linker (CCTCGAGG) | del 221-231 | (A. Velcich and E. Ziff, 1988) | |
| pSVXL105 | del 672-691, ins Xho I linker (CCTCGAGG) | del 38-44, ins SSR | (D.H. Smith et al., 1985; A. Velcich and E. Ziff, 1985; A. Velcich and E. Ziff, 1988) | |
| pSVXL124 | del 1015-1032, ins Xho I linker (CCTCGAGG) | del 153-289 | (A. Velcich and E. Ziff, 1988; A. Velcich and E.B. Ziff, 1989) | impaired for transactivation, does not repress or induce F9 differentiation |
| pSVXL132 | del 746-761, ins Xho I linker (CCTCGAGG) | del 64-67 | (A. Velcich and E. Ziff, 1988; A. Velcich and E.B. Ziff, 1989) | impaired for transformation with ras, repression and induction of F9 differentiation |
| pSVXL174 | del 542-567, ins Xho I linker (CCTCGAGG) | del 1-14 | (A. Velcich and E. Ziff, 1988) | |
| pSVXL185 | del 617-632, ins Xho I linker (CCTCGAGG) | del 20-24 | (A. Velcich and E. Ziff, 1988; A. Velcich and E.B. Ziff, 1989) | impaired for repression and induction of F9 differentiation |
| pSVXL214 | del 1110-1319, ins Xho I linker (CCTCGAGG) | del 185-214 | (A. Velcich and E. Ziff, 1988; A. Velcich and E.B. Ziff, 1989) | transactivation impaired, does not repress or induce F9 differentiation |
| pXAF | insert 8 bp Xho I linker and CT after 1109 | del 185-289, ins SRLQSCV | (K.P. Haley et al., 1984) | in 12S background only |
| pXAS | del 1102-1112, insert 8 bp Xho I linker | del 185-289, ins SRLQSCV | (K.P. Haley et al., 1984) | in 12S background only |
| pXoff | insertion of CTAG after 1343 | substitution of 223-289 with S | (S. Linder et al., 1992) | enhanced invasion |
| R205/206D | CG at 1288, 1289 to GA?, CG at 1291, 1292 to GA? |
R to D at 205, R to D at 206 | (L. Zhu et al., 1993) | does not bind DNA |
| RG2 | R to G at 2 | (H. Wang et al., 1993; S.E. Holt and V.G. Wilson, 1995; J.M. Routes et al., 1996) | defective for viral immortalization of BRK cells, does not repress HIV LTR expression, or induce apoptosis in rat cardiac muscle cells, does not block IFN stimulated gene expression or cytolytic resistance, does not bind p300, reduced binding to pRb and p130, similar mutant to pm 563 | |
| SM171 | (peptide) | C at 171 to A | (M. Green et al., 1988) | disrupts zinc finger, peptide is transactivation defective |
| SM179 | (peptide) | C at 179 to A | (M. Green et al., 1988) | peptide is transactivation defective |
| SmaX | ins Xba I linker after 1008 | del 151-289, ins L | (J.F. Schneider et al., 1987) | CR3 transactivation defective, does not immortalize, truncation |
| S-Stop | del 135-289 | (J.F. Schneider et al., 1987) | CR3 transactivation defective, does not immortalize or transform with ras, truncation | |
| sub315 | del about 1780 bp starting at about 1339, ins about 1500 bp | (N. Jones and T. Shenk, 1979) | host range, Xba I site at 1339 destroyed | |
| sub316 | del about 820 bp starting at about 1339, ins about 1350 bp | (N. Jones and T. Shenk, 1979) | host range, Xba I site at 1339 destroyed | |
| sub1005 | del 671-691 | del 38-44 | (D.H. Smith and E.B. Ziff, 1988) | induces DNA synthesis and transforms with E1B poorly |
| sub1006 | del 647-760 | del 30-67 | (D.H. Smith and E.B. Ziff, 1988) | does not induce DNA synthesis or transform with E1B |
| sub1008 | del 671-760 | del 38-67 | (D.H. Smith and E.B. Ziff, 1988) | does not induce DNA synthesis or transform with E1B |
| sub1015 | del 617-760 | del 20-67 | (D.H. Smith and E.B. Ziff, 1988) | does not induce DNA synthesis or transform with E1B |
| sub1032 | del 749-760 | del 64-67 | (D.H. Smith and E.B. Ziff, 1988) | does not transform with E1B |
| sub1085 | del 617-631 | del 20-24 | (D.H. Smith and E.B. Ziff, 1988) | does not transform with E1B |
| sub1117 | del 1142-1288 | del 185-289 | (T.N. Jelsma et al., 1988; D. Caporossi and S. Bacchetti, 1990) | CR3 transactivation defective, does not induce cytogenetic damage, 11 nucleotide insertion, no 3' splice site |
| SVXCH | del 921-1107, ins ? | del 121-183, ins ENLFCSEEMP SSDDEATA | (E. Moran, 1988) | replaces CR2 of E1A with homologous SV40 sequence, deletes most of CR3, immortalizes poorly, reduced transformation with ras |
| T:1-14/E:20-243 | del 1-20, ins first 14 residues of SV40 Large T antigen | (H. Wang et al., 1993) | does not bind p300 | |
| T:1-24/E:25-243 | del 1-24, ins first 24 residues of SV40 Large T antigen | (P. Yaciuk et al., 1991; H. Wang et al., 1993) | does not bind p300 | |
| XS1 | TCTAA at 1384 replaced with GTTAC | S to V at 237 | (J.L. Douglas et al., 1991) | introduces new Hpa I site |
| XS2 | G to A at 1441 | A to N at 256 | (J.L. Douglas et al., 1991) | introduces new Hpa I site, enhanced transformation with ras |
| XS3 | C to G at 1492 | L to V at 273 | (J.L. Douglas et al., 1991; S. Gopalakrishnan and M.P. Quinlan, 1995) | introduces new Hpa I site, enhanced transformation with ras, interferes with E-cadherin processing and localization |
| XS4 | AGCTGT at 1522 to GTTAAC | S to V at 283, C to N at 284 | (J.L. Douglas et al., 1991; S. Gopalakrishnan et al., 1996) | introduces new Hpa I site, induction of p110-GAP complex impaired |
| XS dl1 | del 1381-1574, ins GT | del 237-289, ins VNAFVC | (J.L. Douglas et al., 1991) | enhanced transformation with ras |
| XS dl2 | del 1441-1574 | del 256-289, ins NAFVC | (J.L. Douglas et al., 1991; S. Gopalakrishnan and M.P. Quinlan, 1995) | enhanced transformation with ras, interferes with E-cadherin processing and localization |
| XS dl3 | C to G at 1492, del 1495 to 1574 | del 273-289, ins VNAFVC | (J.L. Douglas et al., 1991) | enhanced transformation with ras |
| XS dl4 | del 1522-1574, ins GTT | del 283-289, ins VNAFVC | (J.L. Douglas et al., 1991; S. Gopalakrishnan et al., 1996) | slightly enhanced transformation with ras, does not induce p110-GAP complex formation |
| X-Stop | del 127-289 | (J.F. Schneider et al., 1987) | CR3 transactivation defective, does not immortalize or transform with ras, truncation | |
| YG47 | Y to G at 47 | (H. Wang et al., 1993) | does not bind pRb or p130 in HeLa cells, but does bind pRb in BRK cells | |
| YH47 | Y to H at 47 | (H. Wang et al., 1993) | does not bind pRb or p130 in HeLa cells, but does bind pRb in BRK cells |
Last Update = October 29, 2009