Department of
Epidemiology & Biostatistics
Schulich School of Medicine & Dentistry
Winter 2014
Instructors:
Office:
K101D, Kresge Building
Office
Hours: Friday 10:30 a.m. – 11:30 a.m.
Telephone:
(519) 611 -2111 x 87583
E-mail: Sisira.Sarma@schulich.uwo.ca
Monali Malvankar,
PhD
Office: K213, Kresge Building
Office Hours: TBA
Telephone: (519)
611-2111 x 80463
E-mail: Monali.Malvankar@schulich.uwo.ca
Health Economic Evaluation
Inadomi JM. Decision analysis and economic modelling: a
primer. European Journal of Gastroenterology and Hepatology
2004, 16(6): 535-542.
Chung KC, Walters
M, Greenfield ML, Chernew ME. Endoscopic
versus open carpal tunnel release: a cost-effectiveness analysis. Plastic
and Reconstructive Surgery 1998, 102(4), 1089-1099.
Vasen AP, Neptune NJ,
Kuntz KM, Simmons BP, Katz JN. Open versus endoscopic carpal tunnel release: a
decision analysis. Journal of Hand Surgery 1999, 24A, 1109-117.
Lejeune et al. (2005) (TreeAge);
Parameters (excel)
Reference: Use of a decision analysis
model to assess the cost-effectiveness of 18F-FDG PET in the management of metachronous liver metastases of colorectal cancer. Journal of Nuclear Medicine 2005
46(12):2020-2028.
Briggs AH, Goeree R, Blackhouse G, O'Brien
BJ.
Probabilistic analysis of cost-effectiveness models: Choosing between treatment
strategies for gastro-esophageal reflux disease, Medical Decision Making 2002;
22: 290-308.
TreeAge
model (from authors’
website)
Markov Model Basics (Handout)
Example Gray et al,
Ch. 9 (TreeAge Model)
HIV Example Drummond et
al, Ch. 9 (excel)
HIV Example
Drummond et al, Ch. 9 (TreeAge Model)
Rao C, Darzi A, Athanasiou T 2011, Practical examples of the
application of decision analysis in healthcare, Evidence Synthesis in Healthcare:
A Practical Handbook for Clinicians, Editor(s): Darzi,
Athanasiou, Berlin Heidelberg, Springer-Verlag, Pages:221-267.
Briggs and Sculpher Paper (Handout)
Briggs
and Sculpher (1998) (TreeAge
Model – No discount)
Briggs
and Sculpher (TreeAge
Model – half-cycle correction + @3.5% discount)
Briggs
and Sculpher (TreeAge
Model – half-cycle correction + @3.5% discount + PSA)
Background
literature on how to glean probabilities from the Clinical/Epidemiological
studies:
Fleurence RL, Hollenbeak CS. Rates and probabilities in economic
modelling: transformation, translation and appropriate application. Pharmacoeconomics
2007;25(1):3-6.
Spruance SL,
Reid JE, Grace M, Samore M. Hazard ratio in clinical
trials. Antimicrobial Agents and Chemotherapy 2004 Aug;48(8):2787-92.
Moser BK, McCann
MH. Reformulating the hazard ratio to enhance communication
with clinical investigators. Clinical
Trials 2008;5(3):248-252.
Buyse
M. Reformulating the hazard ratio to enhance communication with clinical
investigators.
Clinical Trials 2008;5(6):641-642.
Ishak KJ, Kreif N, Benedict A, Muszbek N. Overview
of parametric survival analysis for health-economic applications. Pharmacoeconomics. 2013 Aug;31(8):663-75.
Hoyle MW, Henley
W. Improved curve fits to summary survival data: application to economic
evaluation of health technologies. BMC
Medical Research Methodology 2011 Oct 10;11:139. (Note: the authors supplied an excel
sheet)
Guyot
P, Ades AE, Ouwens MJ, Welton NJ. Enhanced secondary analysis of survival
data: reconstructing the data from published Kaplan-Meier survival curves. BMC Medical Research Methodology 2012
Feb 1;12:9. (Note:
the authors provide their R codes)
Diaby V, Adunlin G, Montero AJ. Survival modeling for the estimation
of transition probabilities in model-based economic evaluations in the absence
of individual patient data: a tutorial. Pharmacoeconomics 2014 Feb;32(2):101-108.
(Note: authors supplied their
digitized data and approximate survival data based on the algorithm of Guyot et al.,
2014)
Weibull
Transition Probability
Extracting data from KM curves:
Example Data SAS syntax STATA syntax
Hoyle
and Henley Paper: Excel
Sheet
Diaby et al. (2014) – IPD Algorithm R Syntax
Arm1Data: First file Second file IPD1; Arm2Data: First file Second file IPD2; Combined IPD STATA syntax
Some Examples of Costing:
Wolstenholme
J, Rivero-Arias O, Gray A, Molyneux
AJ, Kerr RS, Yarnold JA, Sneade
M; International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group. Treatment pathways, resource use, and costs of endovascular coiling
versus surgical clipping after aSAH. Stroke 2008 Jan;39(1):111-9.
Appendix
Clarke P, Gray
A, Legood R, Briggs A, Holman R. The impact of
diabetes-related complications on healthcare costs: results from the United
Kingdom Prospective Diabetes Study (UKPDS Study No. 65). Diabetic Medicine 2003, 20(6):442-50. Excel
Calculator
Goeree R, Lim ME, Hopkins R, Blackhouse G, Tarride J-E, Xie F, O’Reilly D.
Prevalence, total and excess costs of diabetes and related complications in
Ontario, Canada. Canadian Journal of
Diabetes 2009;33(1):35-45.
Statistical Analysis of Costs:
STATA Syntax
Details at http://www.uphs.upenn.edu/dgimhsr/eeinct.htm
TreeAge Lab Sessions:
Examples of Projects:
Babashov
Vusal’s Project; Model
E.
Ewara, G. Zaric, S. Welch,
S. Sarma. Cost-effectiveness
of first-line treatments for KRAS wild-type metastatic colorectal cancer
patients. Current Oncology,
forthcoming.