Cell Cycle and Genome Instability Laboratory

These are selected publications from my research team.  Each has a link to its citation in PubMed or the journal.

MacDonald, J., Ramos-Valdes, Y., Perampalam, P., Litovchick, L., DiMattia, G.E., and Dick, F.A. (2017) A systematic analysis of negative growth control implicates the DREAM complex in cancer cell dormancy. Mol. Cancer Res. 15, 371-81.

Marshall, A.E., Ishak, C.A., and Dick, F.A. (2020) An RB-Condensin II complex mediates long range chromosome interactions and influences expression at divergently paired genes. Mol. Cell. Biol. 40, in press.

Thwaites, M.J., Cecchini, M.J., Passos, D.T., Welch, I.D., Dick, F.A. (2017) Interchangeable roles for E2F transcriptional repression by the retinoblastoma protein and p27KIP1-CDK regulation in cell cycle control and tumor suppression. Mol. Cell. Biol. 37, e00561-16

Ishak, C.A., Marshall, A.E., Passos, D.T., White, C.R., Kim, S.J., Cecchini, M.J., Ferwati, S., MacDonald, W.A., Howlett, C.J., Welch, I.D., Rubin, S.M., Mann, M.R.W., and Dick, F.A. (2016) An RB-EZH2 complex mediates silencing of repetitive DNA sequences. Mol. Cell 64, 371-381.

Cecchini, M.J., Ishak C.A., Passos, D.T., Warner, A., Palma, D.A., Howlett, C.J., Driman, D.K., Dick, F.A. (2015) Loss of the retinoblastoma tumor suppressor correlates with improved outcome in patients with lung adenocarcinoma treated with surgery and chemotherapy. Human Path. 46, 1922-34.

Coschi, C.H., Ishak, C.A., Gallo, D., Marshall, A., Talluri, S., Wang, J., Cecchini, M.J., Martens, A.L., Percy, V., Welch, I., Boutros, P.C., Brown, G.W., and Dick, F.A. (2014) Haploinsufficiency of an Rb-E2F1-condensin II complex causes aberrant replication and aneuploidy. Cancer Discov. 4, 840-53.

Kareta, M.S., Gorges, L.L, Hafeez, S., Benayoun, B.A., Zmoos, A.-F., Cecchini, M.J., Spacek, D., Batista, L.F.Z., O'Brien, M., Ng, Y.-H., Ang, C.E., Vaka, D., Artandi, S.E., Dick, F.A., Brunet, A., Sage, J., and Wernig, M. (2015) The Rb tumor suppressor restricts reprogramming by directly silencing pluripotency genes. Cell Stem Cell. 16, 39-50.

See commentary on this article in:

See commentary on this article in:       Cancer Discov. 4, 764-65.

Marshall, A.E., Roes, M.V., Passos, D.T., DeWeerd, M.C., Chaikovsky, A.C., Sage, J., Howlett, C.J., and Dick, F.A. (2014) RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression. Mol. Cell. Biol. 39, e00105-19.

Kim, S.J., Asfaha, S., and Dick, F.A. (2019) CDK4 Inhibitors Thwart Immunity by Inhibiting Phospho-RB-NF-kB Complexes. Mol. Cell 73, 1-2.

Dick, F.A., and Rubin, S. (2013) Molecular mechanisms underlying RB protein function. Nat. Rev. Mol. Cell Biol. 14, 297-306

Dick, F.A., Goodrich, D.W., Sage, J., Dyson, N.J. (2018) Non-canonical functions of the RB protein in cancer. Nat. Rev. Cancer. 18, 442-451.


Hirschi, A., Cecchini, M., Steinhardt, R., Schamber, M.R. Dick, F.A., and Rubin, S.M. (2010).  An Overlapping Kinase and Phosphatase Docking Site Regulates Activity of the Retinoblastoma Protein. Nat. Struct. Mol. Biol. 17, 1051-57.

Coschi, C.H., Martens, A.L., Ritchie, K., Francis, S.M., Chakrabarti, S., Berube, N.G., and Dick, F.A. (2010).  Mitotic chromosome condensation by the retinoblastoma protein is tumor suppressive. Genes Dev. 24, 1351-63.

Dick, F.A., and Li, S.S.C. (2019) Drugging RB1 Deficiency: Synthetic Lethality with Aurora Kinases. Cancer Discov. 9, 169-172.

Cancer Discov. 7, 13.

Mol. Cell 64, 1015-17.

See commentary on this article in:

Nat. Rev. Mol. Cell Biol. 11, 541.

Genes Dev. 24, 1329-33.

See commentary on this article in:       Mol. Cancer Res. 15, 359.

See commentary on this article in:       Mol. Cell. Biol. 37, e00623-16.

See commentary on this article in:       Cell 142, 653-55.

Nat. Rev. Cancer. 10, 536.

Nature 466, 1051.

See commentary on this article in:   Mol. Cell. Biol. 40, in press.

See journal cover related to this article:   Mol. Cell. Biol. 39, issue 16