Ultrafine particle technology on titanium based biomaterial

During this project, the utilization of ultrafine particle coating technology in enhancing titanium biomaterial substrates is being optimized. Ultrafine particles with the aid of flow modifiers are applying onto conventional titanium surfaces in the surface enhancing process using a corona electrostatic spray gun and then cured in a curing oven.

The investigations of several ultrafine particle formulations are conducted to elucidate the factors that enhance the biocompatibility as well as osteo-inductivity of titanium substrates for bone implants. Functional additives were optimized to effectively promote the biocompatibility and osteo-inductivity of conventional orthopedic implant substrates. Furthermore, the benefits of incorporating micron-size titanium oxide in backbone polymer are also determined. Both physical examinations and in vitro cellular experiments are conducted to examine their results.

Figure 1: An ultrafine dry powder coating technique was used to create novel biocompatible surface coatings, which were then evaluated in cellular assays.