| Current work |
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Mojmír
Suchý, Christie Ettles, James Wisner, Augusto Matarazzo and Robert
H. E. Hudson “Unusual C- versus normal 5’-O-Dimethoxytritylation
of Pyrrolocyidine Analogues”
Journal of Organic Chemistry,
2016,
81(18), 8415–8425. |
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Mojmir Suchý, Alex X. Li, Mark Milne, Robert Bartha and Robert .H.E.
Hudson “DOTMA-based amides (DOTMAMs) as a platform for the
development of PARACEST MRI contrast agents”
RSC Advances, 2016,
6(67), 62647-62655.
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Mojmír
Suchý, Alex X. Li, Yin Liu, Qingping Feng, Robert Bartha and Robert
H. E. Hudson “Synthesis and Preliminary Evaluation of Contrast
Agents for the Detection of Nitric Oxide Synthase (NOS) enzymatic
activity by ParaCEST MRI”,
Canadian Journal of Chemistry,
2016,
94(8), 715-722. |
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Madalena Kozachuk, Ronald Martin, Andrew Nelson, Robert Hudson,
Sheila Macfie, Mark Biesinger, Mary Jane Walzak, Lisa Ellis,
Alexandra Suda, Arlen Heginbotham "Possible Radiation-Induced Damage to the Molecular Structure of Wooden
Artifacts Due to Micro-Computed Tomography, Handheld X-Ray
Fluorescence, and X-Ray Photoelectron Spectroscopic Techniques”
Journal of Conservation and Museum Studies,
2016,
14(1),
1-6.
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Xiaoxiao Wang and Robert H.E. Hudson
“A PNA Molecular Beacon
Assembled by Post-Synthetic “Click” Chemistry Functionalization”
ChemBioChem, 2015,
16, 2156–2161. |
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Mojmír Suchý, Mark Milne, Adam A. H. Elmehriki, Nevin McVicar,
Robert Bartha and Robert H. E. Hudson
“Decreasing the overall positive charge of Tm3+ DOTAM-alkyl
complexes by introduction of terminal carboxylate groups and
conjugation with Asp-OH: Implications for detection sensitivity and
in vivo toxicity of PARACEST MRI contrast agents”
Journal of Medicinal Chemistry,
2015,
58(16), 6516-6532. |
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Jonatan A. Snir, Mojmir Suchy, Keith St. Lawrence, Robert
H.E. Hudson, Stephen H. Pasternak and Robert Bartha*
“Prolonged In-vivo Retention of a
Cathepsin D Targeted Contrast Agent in Alzheimer’s Disease”
Journal of Alzheimer's Disease,
2015,
48(1),
73-87. |
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Gobbo, Pierangelo; Luo, Wilson; Cho, Sung Ju; Wang, Xiaoxiao;
Biesinger, Mark C.; Hudson, Robert H. E.; Workentin, Mark S. "Small
gold nanoparticles for interfacial Staudinger-Bertozzi ligation"
Organic & Biomolecular Chemistry, 2015,
13,4 605-4612. |
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Matarazzo, Augusto; Hudson, Robert H. E., "Fluorescent
adenosine analogs: a comprehensive survey"
Tetrahedron, 2015, 71(11), 1627-1657
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Lewis, Melissa M.; Milne, Mark; Bartha,
Robert; Hudson, Robert H. E.. "Dysprosium(III)
and thulium(III) complexes of DO3A-monoanilides: an investigation
of electronic effects on their relaxometric and amide-based
PARACEST properties" Canadian Journal of Chemistry,
2015, 93(2), 244-252. |
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Wang, Xiaoxiao; Gobbo, Pierangelo; Suchy,
Mojmir; Workentin, Mark S.; Hudson, Robert H. E.
"Peptide-decorated
gold nanoparticles via strain-promoted azide-alkyne cycloaddition
and post assembly deprotection" RSC Advances, 2014, 4(81), 43087-43091.
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Hudson, Robert H. E.; Moustafa, Mohamed E.; Boyle, Paul D. "(E)-tert-Butyl
2-(5-{[4-(dimethylamino)phenyl]diazenyl}-2,6-dioxo-1H-pyrimidin-3-yl)acetate
dichloromethane monosolvate" Acta Crystallographica,
Section E: Structure Reports Online 2014, 70(5), o556-o557.
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Suchy, Mojmir; Hudson, Robert H. E.
"Pyrimidine-Fused
Heterocyclic Frameworks Based on an N4-Arylcytosine Scaffold:
Synthesis, Characterization, and PNA Oligomerization of the
Fluorescent Cytosine Analogue 5,6-BenzopC" Journal
of Organic Chemistry 2014, 79(8), 3336-3347.
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Hudson, Robert H.E. "DOTAM-based
chelates for the development of paraCEST contrast agents"
Abstracts of Papers, 247th ACS National Meeting & Exposition,
Dallas, TX, United States, March 16-20, 2014, INOR-741.
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Milne, Mark; Lewis, Melissa; McVicar, Nevin; Suchy, Mojmir; Bartha,
Robert; Hudson, Robert H. E. "MRI
ParaCEST agents that improve amide based pH measurements by limiting
inner sphere water T2 exchange"
RSC Advances 2014, 4(4), 1666-1674.
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McVicar, Nevin; Li, Alex X.; Suchy, Mojmir; Hudson,
Robert H. E.; Menon, Ravi S.; Bartha, Robert "Simultaneous
in vivo pH and temperature mapping using PARACEST-MRI contrast
agent" Magnetic Resonance in Medicine, 2013, 70(4), 1016-1025.
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Matarazzo, Augusto; Moustafa, Mohamed, Hudson, Robert H. E. "5-(Acridin-9-yl-amino)uracil
- A hydrolytically labile nucleobase modification in peptide nucleic
acid" Canadian Journal of Chemistry 2013, 91(12), 1202-1206. |
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Mark Milne ,
Pierangelo Gobbo,
Nevin
McVicar, Mark S. Workentin, Robert Bartha and Robert H. E. Hudson* “Water soluble gold
nanoparticles functionalized with gadolinium through Michael
addition for use as a MRI contrast agent” Journal of
Materials Chemistry B: Materials for Biology and Medicine,
2013, 1(41), 5628-5635 |
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K. Chicas and R.H.E. Hudson,
"Expanding the Nucleic Acid Chemist's Toolbox: New Fluorescent
Cytidine Analogues" in Fluorescent Analogues of Biomolecular
Building Blocks: Design and Applications, Ed.s. Y. Tor and M.
Wilhelmmson, John Wiley and Sons, 2012, submitted
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Mark Milne†,
Todd K. Stevens, Adam A. Elmehriki, Mojmir Suchy, Robert Bartha,
Robert H. E. Hudson
“Overcoming Biological MT Effects by use of
ParaCEST MRI Contrast Agents Possessing Highly Shifted Amide Proton
Signals” Proceedings from OctoberCEST,
CMMI,
2012
submitted
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Nevin McVicar†,
Alex X. Li,
Mojmir Suchy, Robert H.E. Hudson, Ravi S. Menon, and Robert Bartha
“Mapping In-vivo pH and Temperature Using a PARACEST-MRI
Contrast Agent”
Proceedings from OctoberCEST,
CMMI,
2012
submitted
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Mojmír Suchý†,
Alex X. Li, Mark Milne, Robert Bartha and Robert H. E. Hudson
“Contrast agents for the detection of
NOS enzymatic activity by
PARACEST MRI”
Proceedings from
OctoberCEST,
CMMI,
2012
submitted
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Accepted and Published |
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André H. St. Amant, Christopher Engbers and Robert
H.E. Hudson* “A Solid-Phase CuAAC Strategy for the Synthesis of PNA
Containing Nucleobase Surrogates”
Artificial DNA: PNA & XNA,
2013, 4, 4-10. |
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Mojmír Suchý, Robert Bartha and
Robert H. E. Hudson* “Click” chemistry toward
bis(DOTA-derived)
heterometallic complexes:
potential bimodal MRI/PET(SPECT) molecular imaging probes”
RSC Advances,
2013,
3(10), 3249-3259,
DOI:
10.1039/C3RA23260C |
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Todd K. Stevens, Mark Milne, Adam A.
H. Elmehriki, Mojmír Suchý, Robert Bartha, Robert H. E. Hudson* “A
DOTAM–based paraCEST agent favoring TSAP geometry for enhanced amide
proton chemical shift dispersion and temperature sensitivity”
Contrast
Media
Molecular
Imaging,
2013, 8(3), 289-292
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Adam A. H. Elmehriki, Mark Milne,
Mojmír Suchý, Robert Bartha and Robert H. E. Hudson*
“Complexes of Selected Late Period Lanthanide(III) Cations with
DOTAM-Alkyl Ligands: A New Platform for the Development of
PARACEST MRI Contrast Agents”
Canadian Journal of Chemistry,
2013, 91(3), 211-219.
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Alex
X. Li, Mojmir Suchy, Robert H.E. Hudson, Ravi S. Menon, Robert
Bartha†
“Simultaneous In Vivo Temperature and pH Mapping Using a PARACEST-MRI
Contrast Agent” Magnetic
Resonance in Medicine, 2013, 70(4), 1016-1025.
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Robert Ta, Mojmir Suchy, Alex X. Li,
Robert H.E. Hudson, Robert Bartha, Stephen H. Pasternak†
“A Dual Magnetic Resonance Imaging/Fluorescent Contrast Agent for
Cathepsin-D Detection”
Contrast Media and Molecular Imaging,
2013, 8(2), 127-139
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André H. St Amant, Leslie A. Bean,
J. Peter Guthrie and Robert H.E. Hudson†
“Click Fleximers: A Modular Approach to Expanded Purine Nucleobases”
Organic and Biomolecular
Chemistry, 2012, 10(32), 6521-6525.
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Mojmír Suchý, Mark
Milne, David W. Dodd, Alex X. Li, Nevin McVicar, Robert Bartha and
Robert H. E. Hudson†
“Polyaza Macrocyclic Ligands Possessing Arginine
Pendant Groups for Use in PARACEST”, Contrast
Media and Molecular Imaging, 2012, 7(5), 441-449.
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Mojmír Suchý and Robert
H. E. Hudson “Alkylation of Cyclic Amines with Arginine Modified
Electrophiles” Synlett, 2012,
23(6), 893-896.
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Haifeng Song, Piotr M. Diakowski,
Robert H. E. Hudson,
Heinz-Bernhard Kraatz, “Effect of Ferrocene Position on
Charge Transfer in ds-DNA Films” Journal of Inorganic and
Organometallic Polymers and Materials,
2012,22(1), 178-182.
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André H. St. Amant and Robert H.E.
Hudson† “Synthesis and Oligomerization of
Fmoc/Boc-Protected PNA Monomers of 2,6-Diaminopurine, 2-Aminopurine
and Thymine” Organic and
Biomolecular Chemistry, 2012,10(4), 876-881.
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Adrian G.
Torres, Martin M. Fabani, Elena Vigorito, Donna Williams, Naowras
Al-Obaidi, Filip Wojciechowski, Robert H. E. Hudson, Oliver Seitz
and Michael J. Gait “Structural and mechanistic aspects
of microRNA-122 inhibition by anti-miR Peptide Nucleic Acids”
Nucleic Acids Research,
2012, 40(5), 2152-2167.
Doi:10.1093/nar/gkr885.
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Mark Milne,
Kirby Chicas, Alex Li, Robert Barthab and Robert H.E.
Hudson†
“ParaCEST MRI Contrast Agents
Capable of Derivatization via “Click” Chemistry”
Organic and Biomolecular
Chemistry, 2012,
10(2), 287-292. DOI:10.1039/C1OB06162C.
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Mojmír Suchý, Mark Milne, David W. Dodd, Alex X. Li, Nevin McVicar,
Robert Bartha and Robert H. E. Hudson†
“Mono- and Tetraalkyne Modified Ligands and Their Eu3+
Complexes: Utilizing ‘Click’ Chemistry to Expand the Scope of
Conjugation Chemistry”
European Journal of Organic Chemistry,
2011,
2011(32), 6532-6543.
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Kalen N. Swanick, David W. Dodd, Jacqueline T. Price,
Nathan D. Jones, Robert H.E. Hudson and Zhifeng Ding† "Electrogenerated Chemiluminescence of Modified
Trizolyldeoxycytidine Analogues in
N,N-Dimethylformamide"
Physical Chemistry Chemical Physics,
2011, 13(38), 17405-17412.
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Mojmir Suchy, Adam Elmehriki and Robert H.E. Hudson†
“A Remarkably Simple Protocol
for the N-Formylation of
Amino Acid Esters and Primary Amines”
Organic Letters, 2011,
13(15), 3952-3955.
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Mark Milne and Robert H.E. Hudson†
“Contrast agents possessing high temperature sensitivity”
Chemical Communications,
2011, 47(32), 9194-9196.
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Mohamed A.E. Moustafa and Robert H.E. Hudson†
“An Azo-based PNA Monomer: Synthesis and Spectroscopic studies” Nucleosides, Nucleotides and Nucleic Acids,
2011, 30(9), 740-751.
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Alexander Wahba,
Fereshteh Azizi, Glen Deleavey, Claire Brown, Francis Robert,
Marylin Carrier, Anna Kalota, Alan Gewirtz, Jerry Pelletier, Robert
Hudson, Masad Damha†
“Phenylpyrrolocytosine-modified siRNA: Unobtrusive
base modification for monitoring activity and cellular trafficking”
ACS Chemical Biology,
2011,
6(9), 912-919.
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David W. Dodd,
Sashko Damjanovsk
and Robert H.E. Hudson†
“Peptide Nucleic Acid Pt(II) Conjugates: A Preliminary Study of
Antisense Effects in Xenopus
laevis”
Nucleosides, Nucleotides and Nucleic Acids,
2011, 30(4), 257-263.
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Rebecca Guza, Delshanee Kotandeniya, Kristopher Murphy,Thakshila
Dissanayake Chen Lin, George Madalin Giambasu, Rahul R. Lad, Filip
Wojciechowski, Shantu Amin, Shana J. Sturla, Robert H.E. Hudson,
Darrin M. York, Ryszard Jankowiak, Roger Jones and Natalia Y.
Tretyakova† “Influence of C-5 substituted cytosine and related nucleoside analogs
on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG
base pairs of DNA” Nucleic
Acids Research, 2011,
39(9), 3988-4006
doi:10.1093/nar/gkq1341.
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David W. Dodd and Robert H.E. Hudson†
“Hydrogelation abilities
of nucleobase-modified cytidines possessing substituted triazoles”
Artificial DNA, 2010,
1(2), 90-95.
doi: 10.4161/adna.1.2.13975
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Alex X. Li, Mojmir Suchy, Chunhui Li, Joseph S. Gati,
Susan Meakin, Robert H.E. Hudson, Ravi S. Menon and Robert Bartha†
“ In vivo Detection of MRI-PARACEST Agents in Mouse Brain Tumors at
9.4 Tesla” Magnetic Resonance
in Medicine, 2011,
66(1), 67-72.
doi: 10.1002/mrm.22772
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Mojmír Suchý, Alex X. Li,
Robert Bartha, and Robert H. E. Hudson†
“Synthesis of MRI contrast agents derived from DOTAM-Gly-L-Phe-OH
incorporating a disulfide bridge: conjugation to a cell
penetrating peptide and preparation of a dimeric agent”
Biological and Medicinal
Chemistry Letters, 2010,
20(18), 5521-5526.
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Mojmír Suchý, Robert Ta, Alex X. Li,
Filip Wojciechowski, Stephen H. Pasternak,
Robert Bartha and Robert H.E. Hudson†
“A
PARACEST-based MRI Probe Metabolized by Cathepsin D: Design,
Synthesis and Cellular Uptake Studies” Organic and Biomolecular
Chemistry, 2010, 8,
2560-2566.
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Mojmír Suchý, Alex X. Li, Robert Bartha, and Robert H. E. Hudson†
“A bifunctional chelator
featuring the DOTAM-Gly-L-Phe-OH
structural subunit: en route
toward homo- and heterobimetallic lanthanide(III) complexes as
PARACEST MRI contrast agents”
Tetrahedron Letters,
2010,
51(7), 1087-1090.
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Craig
K Jones, Alex X. Li, Mojmír Suchý, Robert Hudson*, Ravi S Menon*,
Robert Bartha*,† “In
Vivo Detection of PARACEST Agents With Relaxation Correction”
Magnetic Resonance in Medicine,
2010, 63, 1184-1192.
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David W. Dodd, Kalen N.
Swanick, Jacqueline
T. Price, Allison L.
Brazeau, Zhifeng Ding,
Nathan D. Jones, Robert H.E.
Hudson†
“Blue Fluorescent
Cytidine Analogs: convergent synthesis,
solid-state and
electronic structure, and solvatochromism”,
Organic and Biomolecular Chemistry, 2010,
8(3), 663-666.
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Alexander S. Wahba, Abbasali Esmaeili, Masad J. Damha† and Robert H. E. Hudson†
“A Single-Label Phenylpyrrolocytidine Provides a Molecular
Beacon-Like Response Reporting HIV-1 RT RNase H Activity”,
Nucleic Acids Research,
2010,
38(3),
1048-1056.
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Filip Wojciechowski and Robert H.E. Hudson†
“Peptide
Nucleic Acid Containing a meta-Substituted Phenylpyrrolocytosine
Exhibits a Fluorescence Response and Increased Binding Affinity
Towards RNA” Organic Letters, 2009,
11(21), 4878–4881.
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Jiaxin Hua, David W. Dodd, Robert H. E. Hudson†
and
David R. Corey† “Cellular localization and allele-selective inhibition
of mutant huntingtin protein by peptide nucleic acid oligomers
containing the fluorescent nucleobase [bis-o-(aminoethoxy)phenyl]pyrrolocytosine”
Bioorganic & Medicinal
Chemistry Letters, 2009,
19,
6181-6184.
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Tsvetan G. Gantchev, Sonia Girouard, David W. Dodd,
Filip Wojciechowski, Robert H. E. Hudson and Darel J. Hunting†
“Gamma-Radiation Induced Interstrand Crosslinks in PNA:DNA
Heteroduplexes”
Biochemistry, 2009,
48(29), 7032–7044.
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Alex X. Li, Mojmir Suchy, Craig K. Jones, Robert H.E.
Hudson, Ravi S. Menon and Robert Bartha†
“Optimized MRI Contrast for On-Resonance Proton Exchange Processes
of PARACEST Agents in Biological Systems”,
Magnetic Resonance in
Medicine, 2009,
62(5), 1282-1291.
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David Dodd and
Robert H.E. Hudson†
“Intrinsically Fluorescent Base-Discriminating Nucleosides and
Analogs”, MiniReviews in
Organic Chemistry, 2009, 4,
378-391.
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Alex X. Li, Robert H.E. Hudson, John Barrett, Craig Jones, Stephen
Pasternak and Robert Bartha†
“Four-Pool Modeling of Proton Exchange Processes in Biological
Systems in the Presence of MRI-PARACEST Agents”
Magnetic Resonance in Medicine,
2008,
60, 1197–1206.
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Mojmír Suchý, Robert H. E. Hudson†
“Synthetic Strategies Toward N-Functionalized Cyclens”,
Eur. J. Org. Chem.,
2008, 29, 4847-4865.
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David
Dodd, Heather Toews, Michael Trevail, Nathan D. Jones† and Robert H.E. Hudson† “Synthesis and In-vitro Reactivity of Chiral
cis-Dicholoropyridyloxazoline Platinum (II) Complexes”
Canadian Journal of Chemistry, 2008, 87(1), 321-327.
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Filip Wojciechowski and Robert H.E. Hudson†
“A
Fmoc/Boc Pseudoisocytosine Monomer for Peptide Nucleic Acid
Synthesis”
Canadian Journal of Chemistry, 2008,
130(38),
12574 - 12575.
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Filip
Wojciechowski and
Robert H.E. Hudson “Fluorescence and Hybridization Properties of Peptide Nucleic Acid
Containing a Substituted Phenylpyrrolocytosine Designed to Engage
Guanine with an Additional H-Bond”
Journal of the American
Chemical Society, 2008,
130(38), 12574-12575.
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Mojmír Suchý, Alex X. Li, Robert Bartha and Robert H.E. Hudson†
“A new synthesis of cystamine modified Eu3+ DOTAM-Gly-Phe-OH: a
conjugation ready temperature sensitive MRI contrast agent”
Organic & Biomolecular
Chemistry, 2008,
6(19), 3588-3596.
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Mojmír Suchý,Alex X. Li, Robert Bartha and Robert H.E. Hudson† “Analogs of Eu3+
DOTAM-Gly-Phe-OH and Tm3+ DOTAM-Gly-Lys-OH: Synthesis and
Magnetic Properties of Potential PARACEST MRI Contrast Agents”
Bioorganic and Medicinal Chemistry,
2008,
16(11),
6156-6166.
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Filip Wojciechowski and Robert H.E. Hudson†
“A Convenient Route to N-[2-(Fmoc)-Aminoethyl]glycine Esters and PNA
Oligomerization Using a bis-Boc Nucleobase Protecting Group
Strategy” Journal of Organic
Chemistry, 2008,
73(10), 3807-3816
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Alex X. Li, Filip Wojciechowski, Mojmir Suchy, Robert H.E. Hudson,
Ravi Menon and Robert Bartha†
“A Sensitive PARACEST Contrast Agent for In-vivo Temperature MRI: Eu3+-DOTAM-Gly-Phe”
Magnetic Resonance in Medicine,
2008,
59, 374-381.
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David Dodd and Robert H.E. Hudson†
“Analysis and Purification of Peptide Nucleic Acid by Denaturing
Polyacrylamide Gel Electrophoresis”
Electrophoresis, 2007, 28(21),
3884-3889.
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Filip Wojciechowski, Mojmir Suchy, Alex X. Li, Hassan Azab, Robert
Bartha and Robert H.E. Hudson†
“A Robust and Convergent Synthesis of Dipeptide-Cyclen Conjugates as
Chelators for Lanthanide Ions:
New Paracest MRI
Agents” Bioconjugate Chemistry,
2007, 18, 1625-1636.
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Robert H. E. Hudson†
and Arash Ghorbani Choghamarani “Oligonucleotides Incorporating
Structurally Simple 5-Alkynyl-2’-Deoxyuridines Fluorometrically
Respond to Hybridization”
Organic and Biomolecular Chemistry,
2007, 5(12),
1845-1848.
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Robert H. E. Hudson†
and Arash Ghorbani-Choghamarani “Selective Fluorometric Detection of
Guanosine-Containing Sequences by 6-Phenylpyrrolocytidine in DNA”
Synlett,
2007,
6,
870-873.
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Robert H.E. Hudson†,
Yuhong Liu and Filip Wojciechowski “Hydrophilic Nucleobase
Modifications in Peptide Nucleic Acid:
Synthesis and Properties of PNA Containing 5-Hydroxymethyl-
Uracil and Cytosine” Canadian
Journal of Chemistry,
2007,
85(4), 302-312.
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Filip Wojciechowski and Robert H.E. Hudson “Nucleobase Modifications
in Peptide Nucleic Acids” Curr.
Top. Med. Chem. 2007,
7, 667-679.
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Benedicte M. Patureau, Robert H.E. Hudson†,
Masad J. Damha†
“Induction of RNase H activity by arabinose-peptide
nucleic acids chimeras”
Bioconjugate Chemistry,
2007,
18(2),
421-430.
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Robert H.E. Hudson† and Andrew K. Dambenieks “Synthesis
of N1-unsubstituted 5-alkynylcytosine and derivatives thereof”
Heterocycles,
2006,
68(7),
1325 - 1328.
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Robert H.E Hudson† and Joanne M. Moszynski “A facile
synthesis of fluorophores based on 5-phenylethynyluracils”
Synlett, 2006,
18, 2997-3000.
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Robert H.E. Hudson and Filip Wojciechowski “The detrimental effect
of orotic acid substitution in the peptide nucleic acid strand on
the stability of PNA2:NA triple helices”
Can. J. Chem.,
2005,
83(10), 1731-1740.
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R.H.E. Hudson, M. Goncharenko, A. Wallman, F. Wojciechowski
“PNA-directed triple-helix formation by N7-xanthine” SynLett
2005, 9, 1442-1446.
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R.H.E. Hudson†, A.K. Dambenieks, R.D. Viirre “Fluorescent
7-deazapurine derivatives from 5-iodocytosine via a tandem
cross-coupling/annulation reaction” Synlett 2004,
13, 2400-2402.
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R.H.E. Hudson†, R.D. Viirre, Y.H. Liu, F. Wojciechowski,
A.K. Dambenieks “Chemistry for the synthesis of
Nucleobase-Modified Peptide Nucleic Acid” Pure & Applied
Chemistry 2004, 76
(7-8), 1591-1598.
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L.G. Nikolcheva, C.M. Vogels, R.A. Stefan, H.A. Darwish, S.J. Duffy,
R.J Ireland, A. Decken, R.H.E. Hudson†,
S.A Westcott†
“Synthesis and in vitro reactivity of cis-dichloro(pyridin-2-ylcarboxaldimine)platinum(II)
complexes with DNA” Canadian Journal of Chemistry 2003,
81(4), 269-274.
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R.D.
Viirre and R.H.E. Hudson† “A convenient and scalable
synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its
hydrochloride. Key intermediates for peptide nucleic acid synthesis”
Journal of Organic Chemistry 2003, 68 (4),
1630-1632.
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A.S. King, L.G. Nikolcheva, C.R. Graves, A. Kaminski, C.M. Vogels,
R.H.E. Hudson, R.J. Ireland, S.J. Duffy, S.A. Westcott†
“Synthesis and reactivity of palladium and platinum diimine
complexes containing boronate esters” Canadian Journal of
Chemistry 2002, 80, 1217-1222.
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C. Liu, R.H.E. Hudson and N.O. Petersen†,
“Convergent and sequential synthesis of dendritic, multivalent
complexing agents, Synthesis
2002,
10, 1398-1406.
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R.H.E. Hudson†,
G. Li and J. Tse “The Use of Sonogashira Coupling for the Synthesis
of Modified Uracil Peptide Nucleic Acid Monomers”, Tetrahedron
Letters 2002,
43 (8),
1381-1386.
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R.D. Viirre and R.H.E. Hudson†
"Optimization of a Solid-Phase Synthesis of a PNA
Monomer" Organic Letters 2001, 3, 3931-3934.
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Y.H. Liu and R.H.E. Hudson†,
“A Sulfonic Acid Analog of Peptide Nucleic Acid”, Synlett
2001, 10, 1626-1628.
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S. Carriero, R.S. Braich, R.H.E. Hudson, D. Anglin, J.D. Friesen,
M.J. Damha†
“Inhibition of In-vitro Pre-MRNA Splicing in S. Cerevisiae by
Branched Oligonucleotides”, Nucleosides and Nucleotides
2001,
20,
873-877.
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R.H.E. Hudson, S. Robidoux and M.J. Damha†,
“Divergent Solid-Phase Synthesis of Nucleic Acid Dendrimers”,
Tetrahedron Letters 1998, 39, 1299-1302.
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A.H. Uddin; P.A.E. Piunno; R.H.E. Hudson; M.J. Damha; U.J. Krull†,
"An Assay for the Detection of T•AT Triple-Helical DNA Using
a Fibre Optic Biosensor",
Nucleic Acids Research
1997, 25, 4139-4146
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R.H.E. Hudson and A.J. Poë†,
"Systematic CO Dissociation Kinetics of (m2-H)(H)Os3(CO)10L
Clusters (L=P-donor Ligand)",
Inorganic Chimica Acta,
1997, 259, 257-263.
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R.H.E. Hudson, A.H. Uddin, M.J. Damha†,
"Association of Branched Nucleic Acids: Structural and
Physicochemical Analysis of Antiparallel T*AT Triple-Helical DNA",
Journal of the American Chemical Society
1995, 117, 12470-12477.
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P.A.E. Piunno, U.J. Krull, R.H.E. Hudson, M.J. Damha, H. Cohen,
"Fiber-Optic DNA Sensor for Fluorimetric Nucleic Acid
Determination", Analytical
Chemistry 1995, 67,
2635-2643.
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R.H.E. Hudson, A.J. Poë†,
"Systematic Kinetic Studies of Nucleophile Addition to (m2-H)2Os3(CO)10",
Organometallics
1995, 14,
3238-3248.
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K. Nam, R.H.E. Hudson, K.B. Chapman, K. Ganeshan, M.J. Damha, J.D.
Boeke†, "Yeast Lariat
Debranching Enzyme:
Substrate and Sequence Specificity",
Journal of Biological
Chemistry 1994,
269, 20613-20621.
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.A.E. Piunno, U.J. Krull, R.H.E. Hudson, M.J. Damha, H. Cohen,
"Fiber-Optic Biosensor for Fluorimetric Detection of DNA
Hybridization", Analytical
Chimica Acta, 1994,
288, 205-214.
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R.H.E. Hudson and M.J. Damha†,
"Nucleic Acid Dendrimers - Novel Biopolymer Structures",
Journal of the American
Chemical Society, 1993,
115, 2119-2124.
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M.J. Damha†,
K. Ganeshan, R.H.E. Hudson, S. Zabarylo, "Solid Phase Synthesis
Branched Oligoribo-nucleotides Related to Messenger RNA Splicing
Intermediates", Nucleic Acids
Research, 1992,
20(24), 6565-6573.
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R.H.E. Hudson, A.J. Poë†,
C.N. Sampson, A. Siegal, "Kinetics of Reaction of Hydrogen with [Os3(CO)11NCMe]
and [Os3(CO)10NCMe2],
Journal of the Chemical Society, Dalton Transactions,
1989, 2235-2240.
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Papers in refereed conference proceedings (11)
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Robert H. E. Hudson† and Arash Ghorbani Choghamarani “An
Improved 6-Substituted Pyrrolocytosine for Selective Fluorimetric
Detection of Guanosine-Containing Sequences”
Nucleosides, Nucleotides and
Nucleic Acids, 2007, 26(6-7), 533-537.
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Filip Wojciechowski and Robert H. E. Hudson†
“Synthesis of a Fluorescent PNA Monomer Containing
5-((9H-Fluoren-2-yl)ethynyl)uracil”
Nucleosides, Nucleotides and
Nucleic Acids, 2007,
26 (8-9), 1199-1202.
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Filip Wojciechowski and Robert H. E. Hudson†
“Introduction of Chirality into PNA by Replacement of the Achiral
Methylene Carbonyl Linkage to the Thymine Nucleobase”
Nucleosides, Nucleotides and Nucleic Acids,
2007, 26
26(8-9), 195-1198.
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R.H.E. Hudson†,
A.K. Dambenieks and Joanne M. Moszynski “New Fluorescent Nucleobases
Derived from 5-
Alkynylpyrimidines”
Proceedings of SPIE-The International Society for Optical Engineering, (Photonic Applications in Biosensing and Imaging),
2005, 5969, 59690J1-J10.
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R.H.E. Hudson†,
A.K. Dambenieks and R.D. Viirre “A Direct Synthesis of
Pyrrolocytosine from 5-iodocytosine” Nucleosides, Nucleotides and
Nucleic Acids, 2005, 24(5-7), 581-584.
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R.H.E. Hudson†
and F. Wojciechowski “Synthesis and Properties of
PNA containing Orotic Acid Derivatives”
Nucleosides, Nucleotides and Nucleic Acids, 2005, 24(5-7), 1123-1126.
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R.H.E. Hudson†,
R.D. Viirre, N. McCourt and J. Tse, “Nucleobase Modified Peptide
Nucleic Acid”, Nucleosides, Nucleotides and Nucleic Acids,
2003, 5-8, 1029-1033.
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R.H.E. Hudson†
and J. Tse, “Towards a Circular Bis-Peptide Nucleic Acid”,
Nucleosides, Nucleotides and Nucleic Acids, 2003, 5-8,
1023-1027.
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Conference proceedings (2)
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Alexander S.
Wahba, Masad J. Damha and Robert H.E. Hudson†
“RNA containing pyrrolocytidine base analogs: good
binding affinity and fluorescence that responds to hybridization”
Nucleic Acids Symposium
Series
2008,
52, 399-400.
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Filip Wojciechowski; Robert H.E.
Hudson†
“Exceptional
Fluorescence and Hybridization Properties of a Phenylpyrrolocytosine
in Peptide Nucleic Acid”
Nucleic Acids Symposium Series,
2008,
52, 401-402.
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