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All Publications, by year, in refereed journals (81) Papers currently submitted (2) (1) Robert Ta, Mojmir Suchy, Alex X. Li, Robert H.E. Hudson, Robert Bartha, Stephen H. Pasternak† “A Dual Magnetic Resonance Imaging/Fluorescent Contrast Agent for Cathepsin-D Detection” Contrast Media and Molecular Imaging, 2011, (2) Alex X. Li, Mojmir Suchy,Robert H.E. Hudson, Ravi S. Menon, Robert Bartha† “Simultaneous In Vivo Temperature and pH Mapping Using a PARACEST-MRI Contrast Agent” Magnetic Resonance in Medicine, 2011, 2012 (81) Mojmir Suchy,Robert H.E. Hudson "Alkylation of Cyclic Amines with Arginine Modified Electrophiles", Synlett, 2012, accepted.
2011 (80) André H. St. Amant and Robert H.E. Hudson† “Synthesis and Oligomerization of Fmoc/Boc-Protected PNA Monomers of 2,6-Diaminopurine, 2-Aminopurine and Thymine” Organic and Biomolecular Chemistry, 2011, accepted. (79) Adrian G. Torres, Martin M. Fabani, Elena Vigorito, Donna Williams, Naowras Al-Obaidi, Filip Wojciechowski, Robert H. E. Hudson, Oliver Seitz and Michael J. Gait “Structural and mechanistic aspects of microRNA-122 inhibition by anti-miR Peptide Nucleic Acids” Nucleic Acids Research, 2011, accepted.
(78) Mojmír Suchý, Mark Milne, David W. Dodd, Alex X. Li, Nevin McVicar, Robert Bartha and Robert H. E. Hudson† “ DOTAM-type Ligands Possessing Arginine Pendant Groups for Use in PARACEST MRI”, Contrast Media and Molecular Imaging, 2011, accepted January 2012.
(77) Mark Milne, Kirby Chicas, Alex Li, Robert Barthab and Robert H.E. Hudson† “ParaCEST MRI Contrast Agents Capable of Derivatization via “Click” Chemistry” Organic and Biomolecular Chemistry, 2011. DOI:10.1039/C1OB06162C. (76) Mojmír Suchý, Mark Milne, David W. Dodd, Alex X. Li, Nevin McVicar, Robert Bartha and Robert H. E. Hudson† “Mono- and Tetraalkyne Modified Ligands and Their Eu3+ Complexes: Utilizing ‘Click’ Chemistry to Expand the Scope of Conjugation Chemistry” European Journal of Organic Chemistry, 2011, accepted. (75) Kalen N. Swanick, David W. Dodd, Jacqueline T. Price, Nathan D. Jones, Robert H.E. Hudson and Zhifeng Ding† "Electrogenerated Chemiluminescence of Modified Trizolyldeoxycytidine Analogues in N,N-Dimethylformamide" Physical Chemistry Chemical Physics, 2011, 13(38), 17405-17412. (74) Mojmir Suchy, Adam Elmehriki and Robert H.E. Hudson† “A Remarkably Simple Protocol for the N-Formylation of Amino Acid Esters and Primary Amines” Organic Letters, 2011, 13(15), 3952-3955. (73) Mark Milne and Robert H.E. Hudson† “Contrast agents possessing high temperature sensitivity” Chemical Communications, 2011, 47(32), 9194-9196. (72) Mohamed A.E. Moustafa and Robert H.E. Hudson† “An Azo-based PNA Monomer: Synthesis and Spectroscopic studies” Nucleosides, Nucleotides and Nucleic Acids, 2011, 30(9), 740-751. (71) Alexander Wahba, Fereshteh Azizi, Glen Deleavey, Claire Brown, Francis Robert, Marylin Carrier, Anna Kalota, Alan Gewirtz, Jerry Pelletier, Robert Hudson, Masad Damha† “Phenylpyrrolocytosine-modified siRNA: Unobtrusive base modification for monitoring activity and cellular trafficking” ACS Chemical Biology, 2011, 6(9), 912-919. (70) David W. Dodd, Sashko Damjanovsk and Robert H.E. Hudson† “Peptide Nucleic Acid Pt(II) Conjugates: A Preliminary Study of Antisense Effects in Xenopus laevis” Nucleosides, Nucleotides and Nucleic Acids, 2011, 30(4), 257-263. (69) Rebecca Guza, Delshanee Kotandeniya, Kristopher Murphy,Thakshila Dissanayake Chen Lin, George Madalin Giambasu, Rahul R. Lad, Filip Wojciechowski, Shantu Amin, Shana J. Sturla, Robert H.E. Hudson, Darrin M. York, Ryszard Jankowiak, Roger Jones and Natalia Y. Tretyakova† “Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA” Nucleic Acids Research, 2011, 39(9), 3988-4006 doi:10.1093/nar/gkq1341. (68) David W. Dodd and Robert H.E. Hudson† “Hydrogelation abilities of nucleobase-modified cytidines possessing substituted triazoles” Artificial DNA, 2010, 1(2), 90-95. doi: 10.4161/adna.1.2.13975 (67) Alex X. Li, Mojmir Suchy, Chunhui Li, Joseph S. Gati, Susan Meakin, Robert H.E. Hudson, Ravi S. Menon and Robert Bartha† “ In vivo Detection of MRI-PARACEST Agents in Mouse Brain Tumors at 9.4 Tesla” Magnetic Resonance in Medicine, 2011, 66(1), 67-72. doi: 10.1002/mrm.22772
2010
(63)
Mojmír Suchý, Robert Ta,
Alex X. Li,
Filip Wojciechowski, Stephen H. Pasternak,
Robert Bartha and Robert H.E. Hudson†
“A
PARACEST-based MRI Probe Metabolized by Cathepsin D: Design, Synthesis and
Cellular Uptake Studies” Organic and Biomolecular Chemistry,
2010, 8, 2560-2566.
(62)
Mojmír Suchý, Alex X. Li, Robert Bartha, and Robert H. E. Hudson†
“A bifunctional chelator featuring
the DOTAM-Gly-L-Phe-OH structural
subunit: en route toward homo- and
heterobimetallic lanthanide(III) complexes as PARACEST MRI contrast agents”
Tetrahedron
Letters, 2010,
51(7), 1087-1090.
(61)
Craig K Jones, Alex X. Li,
Mojmír Suchý, Robert Hudson*, Ravi S Menon*, Robert Bartha*,† “In Vivo Detection of
PARACEST Agents With Relaxation Correction”
Magnetic Resonance in Medicine,
2010,
63, 1184-1192.
(60)
David W. Dodd,
Kalen N. Swanick,
Jacqueline T. Price,
Allison L. Brazeau,
Zhifeng Ding,
Nathan D. Jones, Robert H.E. Hudson†
“Blue Fluorescent
Cytidine Analogs: convergent
synthesis,
solid-state and electronic structure, and solvatochromism”, Organic and
Biomolecular Chemistry, 2010,
8(3), 663-666.
(59)
Alexander S. Wahba, Abbasali Esmaeili, Masad J. Damha† and Robert H. E. Hudson†
“A Single-Label Phenylpyrrolocytidine Provides a Molecular Beacon-Like
Response Reporting HIV-1 RT RNase H Activity”,
Nucleic Acids Research,
2010,
38(3),
1048-1056. 2009
(58)
Filip Wojciechowski and Robert H.E. Hudson†
“Peptide
Nucleic Acid Containing a meta-Substituted Phenylpyrrolocytosine Exhibits a
Fluorescence Response and Increased Binding Affinity Towards RNA”
Organic Letters,
2009, 11(21), 4878–4881.
(56)
Tsvetan G. Gantchev, Sonia Girouard, David W. Dodd, Filip Wojciechowski,
Robert H. E. Hudson and Darel J. Hunting† “Gamma-Radiation
Induced Interstrand Crosslinks in PNA:DNA
Heteroduplexes” Biochemistry,
2009, 48(29), 7032–7044. (55) Alex X. Li, Mojmir Suchy, Craig K. Jones, Robert H.E. Hudson, Ravi S. Menon and Robert Bartha† “Optimized MRI Contrast for On-Resonance Proton Exchange Processes of PARACEST Agents in Biological Systems”, Magnetic Resonance in Medicine, 2009, 62(5), 1282-1291. (54) David Dodd and Robert H.E. Hudson† “Intrinsically Fluorescent Base-Discriminating Nucleosides and Analogs”, MiniReviews in Organic Chemistry, 2009, 4, 378-391. (53) Dodd, David W.; Toews, Heather E.; Trevail, Michael J.; Jennings, Michael C.; Hudson, Robert H. E.; Jones, Nathan D. "Synthesis and evaluation of the in vitro DNA-binding properties of chiral cis-dichloro(pyridyloxazoline)platinum(II) complexes" Canadian Journal of Chemistry, 2009, 87(1), 321-327. 2008 (52) Alex X. Li, Robert H.E. Hudson, John Barrett, and Robert Bartha† “Four-Pool Modeling of Proton Exchange Processes in Biological Systems in the Presence of MRI-PARACEST Agents” Magnetic Resonance in Medicine, 01-2008, refereed, revised version submitted. (51) Filip Wojciechowski and Robert H.E. Hudson† “Fluorescence and Hybridization Properties of Peptide Nucleic Acid Containing a Substituted Phenylpyrrolocytosine Designed to Engage Guanine with an Additional H-Bond” Journal of the American Chemical Society, 2008, 130(38), 12574-12575. (50) Mojmír Suchý, Robert H. E. Hudson “Synthetic Strategies Toward N-Functionalized Cyclens”, Eur. J. Org. Chem., 2008, 29, 4847-4865. (49) Filip Wojciechowski and Robert H.E. Hudson† “A Fmoc/Boc Pseudoisocytosine Monomer for Peptide Nucleic Acid Synthesis” Canadian Journal of Chemistry, 2008, in press. (48) Mojmír Suchý, Alex X. Li, Robert Bartha and Robert H.E. Hudson† "A New Synthesis of Cystamine Modified Eu3+ DOTAM-Gly-Phe-OH: A Conjugation Ready Temperature Sensitive MRI Contrast Agent" Organic and Biomolecular Chemistry, 2008, 6(19), 3588-3596. (47) Mojmír Suchý, Alex X. Li, Robert Bartha and Robert H.E. Hudson† “Analogs of Eu3+ DOTAM-Gly-Phe-OH and Tm3+ DOTAM-Gly-Lys-OH: Synthesis and Magnetic Properties of Potential PARACEST MRI Contrast Agents” Bioorganic and Medicinal Chemistry, 2008, 16(11), 6156-6166. (46) Filip Wojciechowski and Robert H.E. Hudson† “A Convenient Route to N-[2-(Fmoc)-Aminoethyl]glycine Esters and PNA Oligomerization Using a bis-Boc Nucleobase Protecting Group Strategy” Journal of Organic Chemistry, 2008, 73(10), 3807-3816. (45) Alex X. Li, Filip Wojciechowski, Mojmir Suchy, Robert H.E. Hudson, Ravi Menon and Robert Bartha† “A Sensitive PARACEST Contrast Agent for In-vivo Temperature MRI: Eu3+-DOTAM-Gly-Phe” Magnetic Resonance in Medicine, 2008, 59, 374-381. 2007 (44) David Dodd and Robert H.E. Hudson† “Analysis and Purification of Peptide Nucleic Acid by Denaturing Polyacrylamide Gel Electrophoresis” Electrophoresis, 2007, 28(21), 3884-3889. (43) Filip Wojciechowski, Mojmir Suchy, Alex X. Li, Hassan Azab, Robert Bartha and Robert H.E. Hudson† “A Robust and Convergent Synthesis of Dipeptide-Cyclen Conjugates as Chelators for Lanthanide Ions: New Paracest MRI Agents” Bioconjugate Chemistry, 2007, 18, 1625-1636. (42) Robert H. E. Hudson† and Arash Ghorbani Choghamarani “Oligonucleotides Incorporating Structurally Simple 5-Alkynyl-2’-Deoxyuridines Fluorometrically Respond to Hybridization” Organic and Biomolecular Chemistry, 2007, 5(12), 1845-1848. (41) Robert H. E. Hudson† and Arash Ghorbani-Choghamarani “Selective Fluorometric Detection of Guanosine-Containing Sequences by 6-Phenylpyrrolocytidine in DNA” Synlett, 2007, 6, 870-873. (40) Robert H.E. Hudson†, Yuhong Liu and Filip Wojciechowski “Hydrophilic Nucleobase Modifications in Peptide Nucleic Acid: Synthesis and Properties of PNA Containing 5-Hydroxymethyl- Uracil and Cytosine” Canadian Journal of Chemistry, 2007, 85(4), 302-312. (39) F. Wojciechowski and R.H.E. Hudson “Nucleobase Modifications in Peptide Nucleic Acids” Curr. Top. Med. Chem. 2007, 7, 667-679. (38) B. Patureau, R.H.E. Hudson†, M.J. Damha† “Induction of RNase H activity by arabinose-peptide nucleic acids chimeras” Bioconjugate Chemistry, 2007, 18(2), 421-430. (37) Robert H. E. Hudson† and Arash Ghorbani Choghamarani “An Improved 6-Substituted Pyrrolocytosine for Selective Fluorimetric Detection of Guanosine-Containing Sequences” Nucleosides, Nucleotides and Nucleic Acids, 2007, 26(6-7), 533-537. (36) Filip Wojciechowski and Robert H. E. Hudson† “Synthesis of a Fluorescent PNA Monomer Containing 5-((9H-Fluoren-2-yl)ethynyl)uracil” Nucleosides, Nucleotides and Nucleic Acids, 2007, 26 (8-9), 1199-1202. (35) Filip Wojciechowski and Robert H. E. Hudson† “Introduction of Chirality into PNA by Replacement of the Achiral Methylene Carbonyl Linkage to the Thymine Nucleobase” Nucleosides, Nucleotides and Nucleic Acids, 2007, 26 26(8-9), 195-1198. 2006 (34) R.H.E. Hudson† and A.K. Dambenieks “Synthesis of N1-unsubstituted 5-alkynylcytosine and derivatives thereof” Heterocycles, 2006, 68(7), 1325-1328. (33) R.H.E. Hudson† and J.M. Moszynski “A facile synthesis of fluorophores based on 5-phenylethynyluracils” Synlett, 2006, 18, 2997-3000. 2005 (32) R.H.E. Hudson and F. Wojciechowski “The detrimental effect of orotic acid substitution in the peptide nucleic acid strand on the stability of PNA2:NA triple helices” Canadian Journal of Chemistry, 2005, 83(10), 1731-1740. (31) R.H.E. Hudson†, A.K. Dambenieks and Joanne M. Moszynski “New Fluorescent Nucleobases Derived from 5-Alkynylpyrimidines”Proceedings of SPIE-The International Society for Optical Engineering, (Photonic Applications in Biosensing and Imaging), 2005, 103-112. (30) R.H.E. Hudson†, M. Goncharenko, A. Wallman, F. Wojciechowski “PNA-directed triple-helix formation by N7-xanthine” SynLett, 2005, 9, 1442-1446. (29) R.H.E. Hudson†, A.K. Dambenieks and R.D. Viirre “A Direct Synthesis of Pyrrolocytosine from 5-iodocytosine” Nucleosides, Nucleotides and Nucleic Acids, 2005, 24(5-7), 581-584. (28) R.H.E. Hudson† and F. Wojciechowski “Synthesis and Properties of PNA containing Orotic Acid Derivatives” Nucleosides, Nucleotides and Nucleic Acids, 2005, 24(5-7), 1123-1126. 2004 (27) R.H.E. Hudson†, A.K. Dambenieks, R.D. Viirre “Fluorescent 7-deazapurine derivatives from 5-iodocytosine via a tandem cross-coupling/annulation reaction” Synlett , 2004, 13, 2400-2402. (26) R.H.E. Hudson†, R.D. Viirre, Y.H. Liu, F. Wojciechowski, A.K. Dambenieks “Chemistry for the synthesis of Nucleobase-Modified Peptide Nucleic Acid” Pure & Applied Chemistry, 2004, 76 (7-8), 1591-1598. 2003 (25) L.G. Nikolcheva, C.M. Vogels, R.A. Stefan, H.A. Darwish, S.J. Duffy, R.J Ireland, A. Decken, R.H.E. Hudson†, S.A Westcott†“Synthesis and in vitro reactivity of cis-dichloro(pyridin-2-ylcarboxaldimine)platinum(II) complexes with DNA” Canadian Journal of Chemistry, 2003, 81 (4), 269-274. (24) R.D. Viirre and R.H.E. Hudson†“A convenient and scalable synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its hydrochloride. Key intermediates for peptide nucleic acid synthesis” Journal of Organic Chemistry, 2003, 68(4), 1630-1632. (23) R.H.E. Hudson†, R.D. Viirre, N. McCourt and J. Tse, “Nucleobase Modified Peptide Nucleic Acid”, Nucleosides, Nucleotides and Nucleic Acids, 2003, 5-8, 1029-1033. (22) R.H.E. Hudson† and J. Tse, “Towards a Circular Bis-Peptide Nucleic Acid", Nucleosides, Nucleotides and Nucleic Acids, 2003, 5-8, 1023-1027. (21) R.H.E. Hudson† and R.D. Viirre, “Progress Towards a Submonomer Synthesis of PNA”, Nucleosides, Nucleotides and Nucleic Acids, 2003, 5-8,1017-1022. 2002 (20) A.S. King, L.G. Nikolcheva, C.R. Graves, A. Kaminski, C.M. Vogels, R.H.E. Hudson, R.J. Ireland, S.J. Duffy, S.A. Westcott† “Synthesis and reactivity of palladium and platinum diimine complexes containing boronate esters” Canadian Journal of Chemistry, 2002, 80, 1217-1222. (19) C. Liu, R.H.E. Hudson and N.O. Petersen† “Convergent and sequential synthesis of dendritic, multivalent complexing agents, Synthesis, 2002, 10, 1398-1406. (18) R.H.E. Hudson†, G. Li and J. Tse “The Use of Sonogashira Coupling for the Synthesis of Modified Uracil Peptide Nucleic Acid Monomers”, Tetrahedron Letters, 2002,43 (8), 1381-1386. 2001 (17) R.D. Viirre and R.H.E. Hudson† "Optimization of a Solid-Phase Synthesis of a PNA Monomer" Organic Letters, 2001, 3, 3931-3934. (16) Y.H. Liu and R.H.E. Hudson† “A Sulfonic Acid Analog of Peptide Nucleic Acid”, Synlett, 2001, 10, 1626-1628. (15) S. Carriero, R.S. Braich, R.H.E. Hudson, D. Anglin, J.D. Friesen, M.J. Damha† “Inhibition of In-vitro Pre-MRNA Splicing in S. Cerevisiae by Branched Oligonucleotides” Nucleosides and Nucleotides, 2001, 20, 873-877. (14) R.H.E. Hudson, “Solid Phase Synthesis – A Practical Approach”, Book Review, Journal of the American Chemical Society, 2001, 123, 781. 1998 (13) R.H.E. Hudson, S. Robidoux and M.J. Damha†, "Divergent Solid-Phase Synthesis of Nucleic Acid Dendrimers”, Tetrahedron Letters, 1998, 39, 1299-1302. 1997 and earlier (12) A.H. Uddin, P.A.E. Piunno, R.H.E. Hudson, M.J. Damha and U.J. Krull† "An Assay for the Detection of T•AT Triple-Helical DNA Using a Fibre Optic Biosensor", Nucleic Acids Research, 1997, 25, 4139-4146. (11) R.H.E. Hudson and A.J. Poë†, "Systematic CO Dissociation Kinetics of (m2-H)(H)Os3(CO)10L Clusters (L=P-donor Ligand)", Inorganic Chimica Acta, 1997, 259, 257-263. (10) R.H.E. Hudson, A.H. Uddin, M.J. Damha†, "Association of Branched Nucleic Acids: Structural and Physicochemical Analysis of Antiparallel T*AT Triple-Helical DNA", Journal of the American Chemical Society 1995, 117, 12470-12477. (9) P.A.E. Piunno, U.J. Krull, R.H.E. Hudson, M.J. Damha, H. Cohen, "Fiber-Optic DNA Sensor for Fluorimetric Nucleic Acid Determination", Analytical Chemistry, 1995, 67, 2635-2643. (8) R.H.E. Hudson, A.J. Poë†, "Systematic Kinetic Studies of Nucleophile Addition to (m2-H)2Os3(CO)10", Organometallics, 1995, 14, 3238-3248. (7) K. Nam, R.H.E. Hudson, K.B. Chapman, K. Ganeshan, M.J. Damha, J.D. Boeke† "Yeast Lariat Debranching Enzyme: Substrate and Sequence Specificity", Journal of Biological Chemistry 1994, 269, 20613-20621. (6) P.A.E. Piunno, U.J. Krull, R.H.E. Hudson, M.J. Damha, H. Cohen, "Fiber-Optic Biosensor for Fluorimetric Detection of DNA Hybridization", Analytical Chimica Acta, 1994, 288, 205-214. (5) R.H.E. Hudson and M.J. Damha†, "Nucleic Acid Dendrimers - Novel Biopolymer Structures", Journal of the American Chemical Society, 1993, 115, 2119-2124. (4) R.H.E. Hudson and M.J. Damha†, "Association of Branched Nucleic Acids", Nucleic Acids Research Symposium Series, 1993, 29, 97-99. (3) M.J. Damha†, K. Ganeshan, R.H.E. Hudson, S. Zabarylo, "Solid Phase Synthesis Branched Oligoribo-nucleotides Related to Messenger RNA Splicing Intermediates", Nucleic Acids Research, 1992, 20(24), 6565-6573. (2) M.J. Damha†, R.H.E. Hudson, K. Ganeshan, S.V. Zabarylo, Y. Guo, "Synthesis and Properties of Branched and Hyperbranched Oligonucleotides", Nucleic Acids Research Symposium Series, 1991, 24, 203-204. (1) R.H.E. Hudson, A.J. Poë†, C.N. Sampson, A. Siegal "Kinetics of Reaction of Hydrogen with [Os3(CO)11NCMe] and [Os3(CO)10NCMe2]", Journal of the Chemical Society, Dalton Transactions, 1989, 2235-2240.
Find out more about our group,
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research and publications by following these links.
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Department of Chemistry Chemistry Building Laboratory 226 The University of Western Ontario
Tel: 519-661-2111x86349 Fax: 519-661-3022 Email: Robert.Hudson
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