DeKoter Lab

Rysan, H., Iansavitchous, J. A., Day, T. M., Uribe Estrada, M., Dou, E., Ye, S., Baronijan, L. H., and DeKoter, R. P.. 2026. H195Y mutation of IKZF3 identified in a mouse model of precursor B cell acute lymphoblastic leukemia impairs transcriptional repression activity and increases protein stability. Journal of Leukocyte Biology. Funded by CIHR 168995 and NSERC 04749-2010.

MacKenzie, A. C. E., Sams, M. P., Lin, J., Reyes Batista, C., Lim, M., Riarh, C. and DeKoter, R. P.. 2024. Negative regulation of activation-induced cytidine deaminase gene transcription in developing B cells by a PU.1-interacting intronic region. BioRxiv. Funded by CIHR 168995.

Sams, M. P., Iansavitchous, J., Astridge, M., Rysan, H., Xu, L. S., Rodrigues de Oliveira, B. and DeKoter, R. P.. 2024. N-acetylcysteine alters disease progression and increases Janus Kinase mutation frequency in a mouse model of precursor B cell acute lymphoblastic leukemia. Journal of Pharmacology and Experimental Therapeutics. Funded by CIHR 142258 and 168995.

Rodrigues de Oliveira, B., Iansavitchous, J., Rysan, H., Wang, W.-C., Sams, M. P., Knight, D., Xu, L. S., Jeong, J., Qu, T. P., and DeKoter, R. P.. 2024. IKZF3/Aiolos H195Y mutation identified in a mouse model of B cell leukemia results in altered DNA binding and altered STAT5-dependent gene expression. Funded by NSERC 2022-03518 and CIHR 168995.

Kim, S. J., Kiser, P. K., Asfaha, S., DeKoter, R. P., and Dick, F. A.. 2023. EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells. The EMBO Journal.

Xu, L. S., Zhu, J. T., Raczowski, H. L., Batista, C. R., and DeKoter, R. P.. 2023. Spi-C and PU.1 counterregulate Rag1 and Igk transcription to effect Vk-Jk recombination in small pre-B cells. The Journal of Immunology. Funded by NSERC 2022-03518.

Raczkowski, H. L. Xu, Li S., Wang, W-C., and DeKoter, R. P.. 2022. The E26 transformation-specific family transcription factor Spi-C is dynamically regulated by external signals in B cells. Immunohorizons. Funded by NSERC 04749-2016.

Raczkowski, H. L. and DeKoter, R. P.. 2021. Lineage-instructive functions of the E26-transformation-specific-family transcription factor Spi-C in immune cell development and disease. WIREs Mechanisms of Disease 2021:e519. Funded by NSERC 04749-2016 and CIHR grants 106581 and 142258.

Lim, M., Batista, C.R., de Oliveira, B.R., Creighton, R., Ferguson, J., Clemmer, K., Knight, D., Iansavitchous, J., Mahmood, D., Avino, M., and DeKoter, R. P. 2020. Janus kinase mutations in mice lacking PU.1 and Spi-B drive B cell leukemia through reactive oxygen species-induced DNA damage. Molecular and Cellular Biology 40:1-19. Funded by The Leukemia & Lymphoma Society of Canada 569086 and CIHR 142258.