DeKoter Lab

Selected Recent Publications

Xu, L. S., Zhu, J. T., Raczowski, H. L., Batista, C. R., and DeKoter, R. P.. 2023. Spi-C and PU.1 counterregulate Rag1 and Igk transcription to effect Vk-Jk recombination in small pre-B cells. The Journal of Immunology. Funded by NSERC 2022-03518.

Raczkowski, H. L. Xu, Li S., Wang, W-C., and DeKoter, R. P.. 2022. The E26 transformation-specific family transcription factor Spi-C is dynamically regulated by external signals in B cells. Immunohorizons. Funded by NSERC 04749-2016.

Raczkowski, H. L. and DeKoter, R. P.. 2021. Lineage-instructive functions of the E26-transformation-specific-family transcription factor Spi-C in immune cell development and disease. WIREs Mechanisms of Disease 2021:e519. Funded by NSERC 04749-2016 and CIHR grants 106581 and 142258.

Lim, M., Batista, C.R., de Oliveira, B.R., Creighton, R., Ferguson, J., Clemmer, K., Knight, D., Iansavitchous, J., Mahmood, D., Avino, M., and DeKoter, R. P. 2020. Janus kinase mutations in mice lacking PU.1 and Spi-B drive B cell leukemia through reactive oxygen species-induced DNA damage. Molecular and Cellular Biology 40:1-19. Funded by The Leukemia & Lymphoma Society of Canada 569086 and CIHR 142258.

Laramée, A.-S., Raczkowski, H.L., Shao, P., Batista, C. R., Shukla, D., Xu, L.S., Haeryfar, S.M., Tesfagiorgis, Y., Kerfoot, S.M., and DeKoter, R. P. 2020. Opposing roles for the related ETS-family transcription factors Spi-B and Spi-C in regulating B cell Differentiation and Function. Frontiers in Immunology 11:841. Funded by CIHR 106581 and 142258 and NSERC 04749-2016.

Ha, S-D., Cho, W., DeKoter, R. P., and Kim, S. O. 2019. The transcription factor PU.1 mediates enhancer-promoter looping that is required for IL-1b eRNA and mRNA transcription in mouse myeloma and macrophage cell lines. The Journal of Biological Chemistry 294:17487-17500.

Xu, L.S., Francis, A., Turkistany, S., Shukla, D., Wong, A., Batista, C.R., and DeKoter, R. P. 2019. ETV6-RUNX1 interacts with a region in SPIB intron 1 to regulate gene expression in pre-B cell acute lymphoblastic leukemia.

Rhee, J., Solomon, L. A., and DeKoter, R. P. 2019. A role for ATP Citrate Lyase in cell cycle regulation during myeloid differentiation.

Batista, C. R., Lim, M., Laramee, A-S., Abu-Sardanah, F., Xu, L. S., Hossain, R., Bell, G. I., Hess, D.A., and DeKoter, R. P. 2018. Driver mutations in Janus Kinases in a mouse model of B-cell leukemia induced by deletion of PU.1 and Spi-B. Blood Advances 2:2798-2810, 2018.