Publications

Visit Robert Hudson's Google Scholar webpage to see a full list of publications.

ORCID record

 

Current Work

2023

Selected recent publications

Mria Chowdhury, Julia A. Turner, Daniela Cappello, Maryam Hajjami, Robert H. E. Hudson,
“Chimeric GFP-uracil based molecular rotor fluorophores” Org. Biomol. Chem., 2023, https://doi.org/10.1039/d3ob01539d

 

Zi Wang, Morgan T. Tamminga, Paul Winiarz, James A. Wisner, Robert H. E. Hudson, “ Organic-Soluble Cytosine Derivatives for Studying Base-Pair Interactions in Nonaqueous Solution” Can J. Chem. 2023, accepted for publication. (Special issue highlighting Excellence in Canadian Undergraduate Chemistry Research)

 

Gyeongsu Park, Christie Ettles, McKenry Charles, Robert H. E. Hudson, “Nucleobase intrinsic quenchers: A fluorescence off switch” J. Photochem. Photobiol., A, 2023, 441, 114653. https://doi.org/10.1016/j.jphotochem.2023.114653

 

Mria Chowdhury, Robert H. E. Hudson, “Exploring Nucleobase Modifications in Oligonucleotide Analogues for Use as Environmentally Responsive Fluorophores and Beyond” Chem. Rec., 2023, 23, e202200218.
https://doi.org/10.1002/tcr.202200218

 

Collaborative Work

Jeremie Mitteaux, Sandy Raevens, Zi Wang, Marc Pirrotta, Ibai Valverde, Robert Hudson, David Monchaud “PhpC modulates G-quadruplex-RNA landscapes in human cells” Chem. Commun. 2023,
https://doi.org/10.1039/d3cc05155b

 

 2022

 

A simple and responsive fluorimetric assay for PNA strand invasion Mason Hermann, Ali Heidari and Robert H.E. Hudson From Biopolymers, (2022),  113(1), e23475, 1-6.

 

2021

Identifying G-Quadruplex-DNA-Disrupting Small Molecules By Mitteaux; Jérémie,  Lejault, Pauline; Pirrotta, Marc; Wojciechowski, Filip; Joubert, Alexandra; Desbois, Nicolas; Gros, Claude; Hudson, Robert; Boulé, Jean-Baptiste; Anton Granzhan, Anton; Monchaud, David.  From Journal of the American Chemical Society (2021), 143 (32), 12567-12577.  

A simple fluorescent assay for the detection of peptide nucleic acid‐directed double strand duplex invasion By Heidari, Ali; Hermann, Mason; Hudson, Robert H.E. From Biopolymers, (2021), e23475

6-​phenylpyrrolocytosine as a fluorescent probe to examine nucleotide flipping catalyzed by a DNA repair protein By Kotandeniya, Delshanee; Rogers, Melanie S.; Fernandez, Jenna; Kanugula, Sreenivas; Hudson, Robert H. E.; Rodriguez, Freddys; Lipscomb, John D.; Tretyakova, Natalia From Biopolymers (2021), 112(1), e23405.   TOC

 2020

Fluorescent biaryl uracils with C5-dihydro- and quinazolinone heterocyclic appendages in PNA By Heidari, Ali; Ghorbani-Choghamarani, Arash; Hajjami, Maryam; Hudson, Robert H. E. From Molecules (2020), 25(8), 1995.  TOC

Disclosing the actual efficiency of G-quadruplex DNA-disrupting small molecules By Mitteaux; Jérémie,  Lejault, Pauline; Pirrotta, Marc; Wojciechowski, Filip; Joubert, Alexandra; Desbois, Nicolas; Gros, Claude; Hudson, Robert; Boulé, Jean-Baptiste; Anton Granzhan, Anton; Monchaud, David. From bioRxiv 2020.11.16.382176;  https://doi.org/10.1101/2020.11.16.382176

2019

On the Necessity of Nucleobase Protection for 2-Thiouracil for Fmoc-Based Pseudo-Complementary Peptide Nucleic Acid Oligomer Synthesis  By Hudson, Robert H. E.; Heidari, Ali; Martin-Chan, Timothy; Park, Gyeongsu; Wisner, James A.  From Journal of Organic Chemistry (2019), 84(21), 13252-13261. TOC

6-Phenylpyrrolocytidine: An Intrinsically Fluorescent, Environmentally Responsive Nucleoside Analogue By Cho, Sung Ju; Ghorbani-Choghamarani, Arash; Saito, Yoshio; Hudson, Robert H. E. From Current Protocols in Nucleic Acid Chemistry (2019), 76(1), n/a.

Detection of active caspase-3 in mouse models of stroke and alzheimer's disease with a novel dual positron emission tomography/fluorescent tracer [68Ga]Ga-TC3-OGDOTA By Ostapchenko, Valeriy G.; Snir, Jonatan; Suchy, Mojmir; Fan, Jue; Cobb, M. Rebecca; Chronik, Blaine A.; Kovacs, Michael; Prado, Vania F.; Hudson, Robert H. E.; Pasternak, Stephen H.; et al From Contrast Media & Molecular Imaging (2019), 6403274/1-6403274/17.

Boehmite@tryptophan-​Pd nanoparticles: A new catalyst for C-​C bond formation By Ghorbani-Choghamarani, Arash; Mohammadi, Masoud; Hudson, Robert H. E.; Tamoradi, Taiebeh From Applied Organometallic Chemistry (2019), 33(8), n/a.

Supported organometallic palladium catalyst into mesoporous channels of magnetic MCM-​41 nanoparticles for phosphine-​free C-​C coupling reactions By Ghorbani-Choghamarani, Arash; Tahmasbi, Bahman; Hudson, Robert H. E.; Heidari, Ali From Microporous and Mesoporous Materials (2019), 284, 366-377. TOC

FSM-​16​/AEPC-​SO3H: Synthesis, Characterization and Its Application for the Catalytic Preparation of 1,​8-​Dioxo-​octahydroxanthene and Tetrahydrobenzo[b]​pyran Derivatives By Hajjami, Maryam; Gholamian, Fatemeh; Hudson, Robert H. E.; Sanati, Ali Mohammad From Catalysis Letters (2019), 149(1), 228-247. TOC

 

2018

An Aspartyl Cathepsin Targeted PET Agent: Application in an Alzheimer's Disease Mouse Model By Snir, Jonatan A.; Suchy, Mojmir; Bindseil, Geron A.; Kovacs, Michael; Chronik, Blaine A.; Hudson, Robert H. E.; Pasternak, Stephen H.; Bartha, Robert From Journal of Alzheimer's Disease ( 2018), 61(3), 1241-1252.

Tribute to J. Peter Guthrie, FCIC, FRSC 1942-2017 By Workentin, Mark S.; Hudson, Robert H. E. From Canadian Journal of Chemistry ( 2018), 96(8), iii-iv.

Synthesis and photophysical evaluation of new fluorescent 7-arylethynyl-7-deazaadenosine analogs By Matarazzo, Augusto; Brow, Justin; Hudson, Robert H. E. From Canadian Journal of Chemistry ( 2018), 96(12), 1093-1100. TOC

A fluorescent 3,​7-​bis-​(naphthalen-​1-​ylethynylated)​-​2'-​deoxyadenosine analogue reports thymidine in complementary DNA by a large emission Stokes shift By Yanagi, Masaki; Suzuki, Azusa; Hudson, Robert H. E.; Saito, Yoshio From Organic & Biomolecular Chemistry ( 2018), 16(9), 1496-1507. TOC

2017

Synthesis of a poly(Gd(III)-DOTA)-PNA conjugate as a potential MRI contrast agent via post-synthetic click chemistry functionalization  By Wang, Xiaoxiao; Milne, Mark; Martinez, Francisco; Scholl, Timothy J.; Hudson, Robert H. E.  From RSC Advances ( 2017), 7(71), 45222-45226.  TOC

The fluorescently responsive 3-​(naphthalen-​1-​ylethynyl)​-​3-​deaza-​2'-​deoxyguanosine discriminates cytidine via the DNA minor groove By Suzuki, Azusa; Yanagi, Masaki; Takeda, Takuya; Hudson, Robert H. E.; Saito, Yoshio From Organic & Biomolecular Chemistry ( 2017), 15(37), 7853-7859. | Language: English, Database: CAPLUS

2016

Mojmír Suchý, Christie Ettles, James Wisner, Augusto Matarazzo and Robert H. E. Hudson “Unusual C7- versus Normal 5'-O-Dimethoxytritylation of 6-Arylpyrrolocytidine Analogs” Journal of Organic Chemistry,  2016, 81(18), 8415–8425.  TOC

Mojmir Suchý, Alex X. Li, Mark Milne, Robert Bartha and Robert .H.E. Hudson “DOTMA-based amides (DOTMAMs) as a platform for the development of PARACEST MRI contrast agents” RSC Advances,  2016, 6(67), 62647-62655. TOC

Mojmír Suchý, Alex X. Li, Yin Liu, Qingping Feng, Robert Bartha and Robert H. E. Hudson “Synthesis and Preliminary Evaluation of Contrast Agents for the Detection of Nitric Oxide Synthase (NOS) enzymatic activity by ParaCEST MRI”, Canadian Journal of Chemistry,  2016, 94(8), 715-722.  TOC

Madalena Kozachuk, Ronald Martin, Andrew Nelson, Robert Hudson, Sheila Macfie, Mark Biesinger, Mary Jane Walzak, Lisa Ellis, Alexandra Suda, Arlen Heginbotham "Possible Radiation-Induced Damage to the Molecular Structure of Wooden Artifacts Due to Micro-Computed Tomography, Handheld X-Ray Fluorescence, and X-Ray Photoelectron Spectroscopic Techniques” Journal of Conservation and Museum Studies, 2016, 14(1), 1-6. 

Expanding The Nucleic Acid Chemist's Toolbox: Fluorescent Cytidine Analogs By Chicas, Kirby; Hudson, Robert H. E. Edited by Wilhelmsson, Marcus; Tor, Yitzhak From Fluorescent Analogues of Biomolecular Building Blocks (2016), 174-207.

2015

Xiaoxiao Wang and Robert H.E. Hudson “A PNA Molecular Beacon Assembled by Post-Synthetic “Click” Chemistry Functionalization” ChemBioChem, 2015, 16, 2156–2161. TOC

Mojmír Suchý, Mark Milne, Adam A. H. Elmehriki, Nevin McVicar, Robert Bartha and Robert H. E. Hudson “Decreasing the overall positive charge of Tm3+ DOTAM-alkyl complexes by introduction of terminal carboxylate groups and conjugation with Asp-OH: Implications for detection sensitivity and in vivo toxicity of PARACEST MRI contrast agents” Journal of Medicinal Chemistry, 2015, 58(16), 6516-6532. TOC

Jonatan A. Snir, Mojmir Suchy, Keith St. Lawrence, Robert H.E. Hudson, Stephen H. Pasternak and Robert Bartha* “Prolonged In-vivo Retention of a Cathepsin D Targeted Contrast Agent in Alzheimer’s Disease” Journal of Alzheimer's Disease, 2015, 48(1), 73-87.

Gobbo, Pierangelo; Luo, Wilson; Cho, Sung Ju; Wang, Xiaoxiao; Biesinger, Mark C.; Hudson, Robert H. E.; Workentin, Mark S. "Small gold nanoparticles for interfacial Staudinger-​Bertozzi ligation" Organic & Biomolecular Chemistry, 2015, 13,4 605-4612. TOC

Matarazzo, Augusto; Hudson, Robert H. E., "Fluorescent adenosine analogs: a comprehensive survey" Tetrahedron, 2015, 71(11), 1627-1657

Lewis, Melissa M.; Milne, Mark; Bartha, Robert; Hudson, Robert H. E. "Dysprosium(III) and thulium(III) complexes of DO3A-​monoanilides: an investigation of electronic effects on their relaxometric and amide-​based PARACEST properties" Canadian Journal of Chemistry, 2015, 93(2), 244-252. TOC

 

2014

Wang, Xiaoxiao; Gobbo, Pierangelo; Suchy, Mojmir; Workentin, Mark S.; Hudson, Robert H. E. "Peptide-​decorated gold nanoparticles via strain-​promoted azide-​alkyne cycloaddition and post assembly deprotection" RSC Advances, 2014, 4(81), 43087-43091. TOC

Hudson, Robert H. E.; Moustafa, Mohamed E.; Boyle, Paul D. "(E)​-​tert-​Butyl 2-​(5-​{[4-​(dimethylamino)​phenyl]​diazenyl}​-​2,​6-​dioxo-​1H-​pyrimidin-​3-​yl)​acetate dichloromethane monosolvate" Acta Crystallographica, Section E: Structure Reports Online 2014, 70(5), o556-o557. TOC

Suchy, Mojmir; Hudson, Robert H. E. "Pyrimidine-​Fused Heterocyclic Frameworks Based on an N4-​Arylcytosine Scaffold: Synthesis, Characterization, and PNA Oligomerization of the Fluorescent Cytosine Analogue 5,​6-​BenzopC" Journal of Organic Chemistry 2014, 79(8), 3336-3347. TOC

Hudson, Robert H.E. "DOTAM-​based chelates for the development of paraCEST contrast agents" Abstracts of Papers, 247th ACS National Meeting & Exposition, Dallas, TX, United States, March 16-20, 2014, INOR-741. 

Milne, Mark; Lewis, Melissa; McVicar, Nevin; Suchy, Mojmir; Bartha, Robert; Hudson, Robert H. E. "MRI ParaCEST agents that improve amide based pH measurements by limiting inner sphere water T2 exchange" RSC Advances 2014, 4(4), 1666-1674.  TOC

2013

McVicar, Nevin; Li, Alex X.; Suchy, Mojmir; Hudson, Robert H. E.; Menon, Ravi S.; Bartha, Robert "Simultaneous in vivo pH and temperature mapping using PARACEST-​MRI contrast agent" Magnetic Resonance in Medicine, 2013, 70(4), 1016-1025.

Matarazzo, Augusto; Moustafa, Mohamed, Hudson, Robert H. E. "5-​(Acridin-​9-​yl-​amino)​uracil - A hydrolytically labile nucleobase modification in peptide nucleic acid" Canadian Journal of Chemistry 2013, 91(12), 1202-1206. TOC

Mark Milne , Pierangelo Gobbo, Nevin McVicar, Mark S. Workentin, Robert Bartha and Robert H. E. Hudson* “Water soluble gold nanoparticles functionalized with gadolinium through Michael addition for use as a MRI contrast agent” Journal of Materials Chemistry B: Materials for Biology and Medicine, 2013, 1(41), 5628-5635.  TOC

 

Past Publications

André H. St. Amant, Christopher Engbers and Robert H.E. Hudson* “A Solid-Phase CuAAC Strategy for the Synthesis of PNA Containing Nucleobase Surrogates” Artificial DNA: PNA & XNA, 2013, 4, 4-10.

Mojmír Suchý, Robert Bartha and Robert H. E. Hudson* “Click” chemistry toward bis(DOTA-derived) heterometallic complexes: potential bimodal MRI/PET(SPECT) molecular imaging probes” RSC Advances, 2013, 3(10), 3249-3259, DOI: 10.1039/C3RA23260C

Todd K. Stevens, Mark Milne, Adam A. H. Elmehriki, Mojmír Suchý, Robert Bartha, Robert H. E. Hudson* “A DOTAM–based paraCEST agent favoring TSAP geometry for enhanced amide proton chemical shift dispersion and temperature sensitivity” Contrast Media Molecular Imaging, 2013, 8(3), 289-292

Adam A. H. Elmehriki, Mark Milne, Mojmír Suchý, Robert Bartha and Robert H. E. Hudson* “Complexes of Selected Late Period Lanthanide(III) Cations with DOTAM-Alkyl Ligands: A New Platform for the Development of PARACEST MRI Contrast Agents” Canadian Journal of Chemistry, 2013, 91(3), 211-219.

Alex X. Li, Mojmir Suchy, Robert H.E. Hudson, Ravi S. Menon, Robert Bartha† “Simultaneous In Vivo Temperature and pH Mapping Using a PARACEST-MRI Contrast Agent” Magnetic Resonance in Medicine, 2013, 70(4), 1016-1025.

Robert Ta, Mojmir Suchy, Alex X. Li, Robert H.E. Hudson, Robert Bartha, Stephen H. Pasternak† “A Dual Magnetic Resonance Imaging/Fluorescent Contrast Agent for Cathepsin-D Detection” Contrast Media and Molecular Imaging, 2013, 8(2), 127-139

André H. St Amant, Leslie A. Bean, J. Peter Guthrie and Robert H.E. Hudson† “Click Fleximers: A Modular Approach to Expanded Purine Nucleobases” Organic and Biomolecular Chemistry, 2012, 10(32), 6521-6525.

Mojmír Suchý, Mark Milne, David W. Dodd, Alex X. Li, Nevin McVicar, Robert Bartha and Robert H. E. Hudson† “Polyaza Macrocyclic Ligands Possessing Arginine Pendant Groups for Use in PARACEST”, Contrast Media and Molecular Imaging, 2012, 7(5), 441-449.

Mojmír Suchý and Robert H. E. Hudson “Alkylation of Cyclic Amines with Arginine Modified Electrophiles” Synlett, 2012, 23(6), 893-896.

Haifeng Song, Piotr M. Diakowski, Robert H. E. Hudson, Heinz-Bernhard Kraatz, “Effect of Ferrocene Position on Charge Transfer in ds-DNA Films” Journal of Inorganic and Organometallic Polymers and Materials, 2012,22(1), 178-182.

André H. St. Amant and Robert H.E. Hudson† “Synthesis and Oligomerization of Fmoc/Boc-Protected PNA Monomers of 2,6-Diaminopurine, 2-Aminopurine and Thymine” Organic and Biomolecular Chemistry, 2012,10(4), 876-881.

Adrian G. Torres, Martin M. Fabani, Elena Vigorito, Donna Williams, Naowras Al-Obaidi, Filip Wojciechowski, Robert H. E. Hudson, Oliver Seitz and Michael J. Gait “Structural and mechanistic aspects of microRNA-122 inhibition by anti-miR Peptide Nucleic Acids” Nucleic Acids Research, 2012, 40(5), 2152-2167. Doi:10.1093/nar/gkr885.

Mark Milne, Kirby Chicas, Alex Li, Robert Barthab and Robert H.E. Hudson† “ParaCEST MRI Contrast Agents Capable of Derivatization via “Click” Chemistry” Organic and Biomolecular Chemistry, 2012, 10(2), 287-292. DOI:10.1039/C1OB06162C.

Mojmír Suchý, Mark Milne, David W. Dodd, Alex X. Li, Nevin McVicar, Robert Bartha and Robert H. E. Hudson† “Mono- and Tetraalkyne Modified Ligands and Their Eu3+ Complexes: Utilizing ‘Click’ Chemistry to Expand the Scope of Conjugation Chemistry” European Journal of Organic Chemistry, 2011, 2011(32), 6532-6543.

Kalen N. Swanick, David W. Dodd, Jacqueline T. Price, Nathan D. Jones, Robert H.E. Hudson and Zhifeng Ding† "Electrogenerated Chemiluminescence of Modified Trizolyldeoxycytidine Analogues in N,N-Dimethylformamide" Physical Chemistry Chemical Physics, 2011, 13(38), 17405-17412.

Mojmir Suchy, Adam Elmehriki and Robert H.E. Hudson† “A Remarkably Simple Protocol for the N-Formylation of Amino Acid Esters and Primary Amines” Organic Letters, 2011, 13(15), 3952-3955.

Mark Milne and Robert H.E. Hudson† “Contrast agents possessing high temperature sensitivity” Chemical Communications, 2011, 47(32), 9194-9196.

Mohamed A.E. Moustafa and Robert H.E. Hudson† “An Azo-based PNA Monomer: Synthesis and Spectroscopic studies” Nucleosides, Nucleotides and Nucleic Acids, 2011, 30(9), 740-751.

Alexander Wahba, Fereshteh Azizi, Glen Deleavey, Claire Brown, Francis Robert, Marylin Carrier, Anna Kalota, Alan Gewirtz, Jerry Pelletier, Robert Hudson, Masad Damha† “Phenylpyrrolocytosine-modified siRNA: Unobtrusive base modification for monitoring activity and cellular trafficking” ACS Chemical Biology, 2011, 6(9), 912-919.

David W. Dodd, Sashko Damjanovsk and Robert H.E. Hudson† “Peptide Nucleic Acid Pt(II) Conjugates: A Preliminary Study of Antisense Effects in Xenopus laevis” Nucleosides, Nucleotides and Nucleic Acids, 2011, 30(4), 257-263.

Rebecca Guza, Delshanee Kotandeniya, Kristopher Murphy,Thakshila Dissanayake Chen Lin, George Madalin Giambasu, Rahul R. Lad, Filip Wojciechowski, Shantu Amin, Shana J. Sturla, Robert H.E. Hudson, Darrin M. York, Ryszard Jankowiak, Roger Jones and Natalia Y. Tretyakova† “Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA” Nucleic Acids Research, 2011, 39(9), 3988-4006 doi:10.1093/nar/gkq1341.

David W. Dodd and Robert H.E. Hudson† “Hydrogelation abilities of nucleobase-modified cytidines possessing substituted triazoles” Artificial DNA, 2010, 1(2), 90-95. doi: 10.4161/adna.1.2.13975

Alex X. Li, Mojmir Suchy, Chunhui Li, Joseph S. Gati, Susan Meakin, Robert H.E. Hudson, Ravi S. Menon and Robert Bartha† “ In vivo Detection of MRI-PARACEST Agents in Mouse Brain Tumors at 9.4 Tesla” Magnetic Resonance in Medicine, 2011, 66(1), 67-72. doi: 10.1002/mrm.22772

Mojmír Suchý, Alex X. Li, Robert Bartha, and Robert H. E. Hudson† “Synthesis of MRI contrast agents derived from DOTAM-Gly-L-Phe-OH incorporating a disulfide bridge: conjugation to a cell penetrating peptide and preparation of a dimeric agent” Biological and Medicinal Chemistry Letters, 2010, 20(18), 5521-5526.

Mojmír Suchý, Robert Ta, Alex X. Li, Filip Wojciechowski, Stephen H. Pasternak, Robert Bartha and Robert H.E. Hudson† “A PARACEST-based MRI Probe Metabolized by Cathepsin D: Design, Synthesis and Cellular Uptake Studies” Organic and Biomolecular Chemistry, 2010, 8, 2560-2566.

Mojmír Suchý, Alex X. Li, Robert Bartha, and Robert H. E. Hudson† “A bifunctional chelator featuring the DOTAM-Gly-L-Phe-OH structural subunit: en route toward homo- and heterobimetallic lanthanide(III) complexes as PARACEST MRI contrast agents” Tetrahedron Letters, 2010, 51(7), 1087-1090.

Craig K Jones, Alex X. Li, Mojmír Suchý, Robert Hudson*, Ravi S Menon*, Robert Bartha*,† “In Vivo Detection of PARACEST Agents With Relaxation Correction” Magnetic Resonance in Medicine, 2010, 63, 1184-1192.

David W. Dodd, Kalen N. Swanick, Jacqueline T. Price, Allison L. Brazeau, Zhifeng Ding, Nathan D. Jones, Robert H.E. Hudson† “Blue Fluorescent Cytidine Analogs: convergent synthesis, solid-state and electronic structure, and solvatochromism”, Organic and Biomolecular Chemistry, 2010, 8(3), 663-666.

Alexander S. Wahba, Abbasali Esmaeili, Masad J. Damha† and Robert H. E. Hudson† “A Single-Label Phenylpyrrolocytidine Provides a Molecular Beacon-Like Response Reporting HIV-1 RT RNase H Activity”, Nucleic Acids Research, 2010, 38(3), 1048-1056.

Filip Wojciechowski and Robert H.E. Hudson† “Peptide Nucleic Acid Containing a meta-Substituted Phenylpyrrolocytosine Exhibits a Fluorescence Response and Increased Binding Affinity Towards RNA” Organic Letters, 2009, 11(21), 4878–4881.

Jiaxin Hua, David W. Dodd, Robert H. E. Hudson† and David R. Corey† “Cellular localization and allele-selective inhibition of mutant huntingtin protein by peptide nucleic acid oligomers containing the fluorescent nucleobase [bis-o-(aminoethoxy)phenyl]pyrrolocytosine” Bioorganic & Medicinal Chemistry Letters, 2009, 19, 6181-6184.

Tsvetan G. Gantchev, Sonia Girouard, David W. Dodd, Filip Wojciechowski, Robert H. E. Hudson and Darel J. Hunting† “Gamma-Radiation Induced Interstrand Crosslinks in PNA:DNA Heteroduplexes” Biochemistry, 2009, 48(29), 7032–7044.

Alex X. Li, Mojmir Suchy, Craig K. Jones, Robert H.E. Hudson, Ravi S. Menon and Robert Bartha† “Optimized MRI Contrast for On-Resonance Proton Exchange Processes of PARACEST Agents in Biological Systems”, Magnetic Resonance in Medicine, 2009, 62(5), 1282-1291.

David Dodd and Robert H.E. Hudson† “Intrinsically Fluorescent Base-Discriminating Nucleosides and Analogs”, MiniReviews in Organic Chemistry, 2009, 4, 378-391.

Alex X. Li, Robert H.E. Hudson, John Barrett, Craig Jones, Stephen Pasternak and Robert Bartha† “Four-Pool Modeling of Proton Exchange Processes in Biological Systems in the Presence of MRI-PARACEST Agents” Magnetic Resonance in Medicine, 2008, 60, 1197–1206.

Mojmír Suchý, Robert H. E. Hudson† “Synthetic Strategies Toward N-Functionalized Cyclens”, Eur. J. Org. Chem., 2008, 29, 4847-4865.

David Dodd, Heather Toews, Michael Trevail, Nathan D. Jones† and Robert H.E. Hudson† “Synthesis and In-vitro Reactivity of Chiral cis-Dicholoropyridyloxazoline Platinum (II) Complexes” Canadian Journal of Chemistry, 2008, 87(1), 321-327.

Filip Wojciechowski and Robert H.E. Hudson† “A Fmoc/Boc Pseudoisocytosine Monomer for Peptide Nucleic Acid Synthesis” Canadian Journal of Chemistry, 2008, 130(38), 12574 - 12575.

Filip Wojciechowski and Robert H.E. Hudson “Fluorescence and Hybridization Properties of Peptide Nucleic Acid Containing a Substituted Phenylpyrrolocytosine Designed to Engage Guanine with an Additional H-Bond” Journal of the American Chemical Society, 2008, 130(38), 12574-12575.

Mojmír Suchý, Alex X. Li, Robert Bartha and Robert H.E. Hudson† “A new synthesis of cystamine modified Eu3+ DOTAM-Gly-Phe-OH: a conjugation ready temperature sensitive MRI contrast agent” Organic & Biomolecular Chemistry, 2008, 6(19), 3588-3596.

Mojmír Suchý,Alex X. Li, Robert Bartha and Robert H.E. Hudson† “Analogs of Eu3+ DOTAM-Gly-Phe-OH and Tm3+ DOTAM-Gly-Lys-OH: Synthesis and Magnetic Properties of Potential PARACEST MRI Contrast Agents” Bioorganic and Medicinal Chemistry, 2008, 16(11), 6156-6166.

Filip Wojciechowski and Robert H.E. Hudson† “A Convenient Route to N-[2-(Fmoc)-Aminoethyl]glycine Esters and PNA Oligomerization Using a bis-Boc Nucleobase Protecting Group Strategy” Journal of Organic Chemistry, 2008, 73(10), 3807-3816

Alex X. Li, Filip Wojciechowski, Mojmir Suchy, Robert H.E. Hudson, Ravi Menon and Robert Bartha† “A Sensitive PARACEST Contrast Agent for In-vivo Temperature MRI: Eu3+-DOTAM-Gly-Phe” Magnetic Resonance in Medicine, 2008, 59, 374-381.

David Dodd and Robert H.E. Hudson† “Analysis and Purification of Peptide Nucleic Acid by Denaturing Polyacrylamide Gel Electrophoresis” Electrophoresis, 2007, 28(21), 3884-3889.

Filip Wojciechowski, Mojmir Suchy, Alex X. Li, Hassan Azab, Robert Bartha and Robert H.E. Hudson† “A Robust and Convergent Synthesis of Dipeptide-Cyclen Conjugates as Chelators for Lanthanide Ions: New Paracest MRI Agents” Bioconjugate Chemistry, 2007, 18, 1625-1636.

Robert H. E. Hudson† and Arash Ghorbani Choghamarani “Oligonucleotides Incorporating Structurally Simple 5-Alkynyl-2’-Deoxyuridines Fluorometrically Respond to Hybridization” Organic and Biomolecular Chemistry, 2007, 5(12), 1845-1848.

Robert H. E. Hudson† and Arash Ghorbani-Choghamarani “Selective Fluorometric Detection of Guanosine-Containing Sequences by 6-Phenylpyrrolocytidine in DNA” Synlett, 2007, 6, 870-873.

Robert H.E. Hudson†, Yuhong Liu and Filip Wojciechowski “Hydrophilic Nucleobase Modifications in Peptide Nucleic Acid: Synthesis and Properties of PNA Containing 5-Hydroxymethyl- Uracil and Cytosine” Canadian Journal of Chemistry, 2007, 85(4), 302-312.

Filip Wojciechowski and Robert H.E. Hudson “Nucleobase Modifications in Peptide Nucleic Acids” Curr. Top. Med. Chem. 2007, 7, 667-679.

Benedicte M. Patureau, Robert H.E. Hudson†, Masad J. Damha† “Induction of RNase H activity by arabinose-peptide nucleic acids chimeras” Bioconjugate Chemistry, 2007, 18(2), 421-430.

Robert H.E. Hudson† and Andrew K. Dambenieks “Synthesis of N1-unsubstituted 5-alkynylcytosine and derivatives thereof” Heterocycles, 2006, 68(7), 1325 - 1328.

Robert H.E Hudson† and Joanne M. Moszynski “A facile synthesis of fluorophores based on 5-phenylethynyluracils” Synlett, 2006, 18, 2997-3000.

Robert H.E. Hudson and Filip Wojciechowski “The detrimental effect of orotic acid substitution in the peptide nucleic acid strand on the stability of PNA2:NA triple helices” Can. J. Chem., 2005, 83(10), 1731-1740.

R.H.E. Hudson, M. Goncharenko, A. Wallman, F. Wojciechowski “PNA-directed triple-helix formation by N7-xanthine” SynLett 2005, 9, 1442-1446.

R.H.E. Hudson†, A.K. Dambenieks, R.D. Viirre “Fluorescent 7-deazapurine derivatives from 5-iodocytosine via a tandem cross-coupling/annulation reaction” Synlett 2004, 13, 2400-2402.

R.H.E. Hudson†, R.D. Viirre, Y.H. Liu, F. Wojciechowski, A.K. Dambenieks “Chemistry for the synthesis of Nucleobase-Modified Peptide Nucleic Acid” Pure & Applied Chemistry 2004, 76 (7-8), 1591-1598.

L.G. Nikolcheva, C.M. Vogels, R.A. Stefan, H.A. Darwish, S.J. Duffy, R.J Ireland, A. Decken, R.H.E. Hudson†, S.A Westcott† “Synthesis and in vitro reactivity of cis-dichloro(pyridin-2-ylcarboxaldimine)platinum(II) complexes with DNA” Canadian Journal of Chemistry 2003, 81(4), 269-274.

R.D. Viirre and R.H.E. Hudson† “A convenient and scalable synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its hydrochloride. Key intermediates for peptide nucleic acid synthesis” Journal of Organic Chemistry 2003, 68 (4), 1630-1632.

A.S. King, L.G. Nikolcheva, C.R. Graves, A. Kaminski, C.M. Vogels, R.H.E. Hudson, R.J. Ireland, S.J. Duffy, S.A. Westcott† “Synthesis and reactivity of palladium and platinum diimine complexes containing boronate esters” Canadian Journal of Chemistry 2002, 80, 1217-1222.

C. Liu, R.H.E. Hudson and N.O. Petersen†, “Convergent and sequential synthesis of dendritic, multivalent complexing agents, Synthesis 2002, 10, 1398-1406.

R.H.E. Hudson†, G. Li and J. Tse “The Use of Sonogashira Coupling for the Synthesis of Modified Uracil Peptide Nucleic Acid Monomers”, Tetrahedron Letters 2002, 43 (8), 1381-1386.

R.D. Viirre and R.H.E. Hudson† "Optimization of a Solid-Phase Synthesis of a PNA Monomer" Organic Letters 2001, 3, 3931-3934.

Y.H. Liu and R.H.E. Hudson†, “A Sulfonic Acid Analog of Peptide Nucleic Acid”, Synlett 2001, 10, 1626-1628.

S. Carriero, R.S. Braich, R.H.E. Hudson, D. Anglin, J.D. Friesen, M.J. Damha† “Inhibition of In-vitro Pre-MRNA Splicing in S. Cerevisiae by Branched Oligonucleotides”, Nucleosides and Nucleotides 2001, 20, 873-877.

R.H.E. Hudson, S. Robidoux and M.J. Damha†, “Divergent Solid-Phase Synthesis of Nucleic Acid Dendrimers”, Tetrahedron Letters 1998, 39, 1299-1302.

A.H. Uddin; P.A.E. Piunno; R.H.E. Hudson; M.J. Damha; U.J. Krull†, "An Assay for the Detection of T•AT Triple-Helical DNA Using a Fibre Optic Biosensor", Nucleic Acids Research 1997, 25, 4139-4146

R.H.E. Hudson and A.J. Poë†, "Systematic CO Dissociation Kinetics of (m2-H)(H)Os3(CO)10L Clusters (L=P-donor Ligand)", Inorganic Chimica Acta, 1997, 259, 257-263.

R.H.E. Hudson, A.H. Uddin, M.J. Damha†, "Association of Branched Nucleic Acids: Structural and Physicochemical Analysis of Antiparallel T*AT Triple-Helical DNA", Journal of the American Chemical Society 1995, 117, 12470-12477.

P.A.E. Piunno, U.J. Krull, R.H.E. Hudson, M.J. Damha, H. Cohen, "Fiber-Optic DNA Sensor for Fluorimetric Nucleic Acid Determination", Analytical Chemistry 1995, 67, 2635-2643.

R.H.E. Hudson, A.J. Poë†, "Systematic Kinetic Studies of Nucleophile Addition to (m2-H)2Os3(CO)10", Organometallics 1995, 14, 3238-3248.

K. Nam, R.H.E. Hudson, K.B. Chapman, K. Ganeshan, M.J. Damha, J.D. Boeke†, "Yeast Lariat Debranching Enzyme: Substrate and Sequence Specificity", Journal of Biological Chemistry 1994, 269, 20613-20621.

.A.E. Piunno, U.J. Krull, R.H.E. Hudson, M.J. Damha, H. Cohen, "Fiber-Optic Biosensor for Fluorimetric Detection of DNA Hybridization", Analytical Chimica Acta, 1994, 288, 205-214.

R.H.E. Hudson and M.J. Damha†, "Nucleic Acid Dendrimers - Novel Biopolymer Structures", Journal of the American Chemical Society, 1993, 115, 2119-2124.

M.J. Damha†, K. Ganeshan, R.H.E. Hudson, S. Zabarylo, "Solid Phase Synthesis Branched Oligoribo-nucleotides Related to Messenger RNA Splicing Intermediates", Nucleic Acids Research, 1992, 20(24), 6565-6573.

R.H.E. Hudson, A.J. Poë†, C.N. Sampson, A. Siegal, "Kinetics of Reaction of Hydrogen with [Os3(CO)11NCMe] and [Os3(CO)10NCMe2], Journal of the Chemical Society, Dalton Transactions, 1989, 2235-2240.

 

Papers in refereed conference proceedings 

Robert H. E. Hudson† and Arash Ghorbani Choghamarani “An Improved 6-Substituted Pyrrolocytosine for Selective Fluorimetric Detection of Guanosine-Containing Sequences” Nucleosides, Nucleotides and Nucleic Acids, 2007, 26(6-7), 533-537.

Filip Wojciechowski and Robert H. E. Hudson† “Synthesis of a Fluorescent PNA Monomer Containing 5-((9H-Fluoren-2-yl)ethynyl)uracil” Nucleosides, Nucleotides and Nucleic Acids, 2007, 26 (8-9), 1199-1202.

Filip Wojciechowski and Robert H. E. Hudson† “Introduction of Chirality into PNA by Replacement of the Achiral Methylene Carbonyl Linkage to the Thymine Nucleobase” Nucleosides, Nucleotides and Nucleic Acids, 2007, 26 26(8-9), 195-1198.

R.H.E. Hudson†, A.K. Dambenieks and Joanne M. Moszynski “New Fluorescent Nucleobases Derived from 5- Alkynylpyrimidines” Proceedings of SPIE-The International Society for Optical Engineering, (Photonic Applications in Biosensing and Imaging), 2005, 5969, 59690J1-J10.

R.H.E. Hudson†, A.K. Dambenieks and R.D. Viirre “A Direct Synthesis of Pyrrolocytosine from 5-iodocytosine” Nucleosides, Nucleotides and Nucleic Acids, 2005, 24(5-7), 581-584.

R.H.E. Hudson† and F. Wojciechowski “Synthesis and Properties of PNA containing Orotic Acid Derivatives” Nucleosides, Nucleotides and Nucleic Acids, 2005, 24(5-7), 1123-1126.

R.H.E. Hudson†, R.D. Viirre, N. McCourt and J. Tse, “Nucleobase Modified Peptide Nucleic Acid”, Nucleosides, Nucleotides and Nucleic Acids, 2003, 5-8, 1029-1033.

R.H.E. Hudson† and J. Tse, “Towards a Circular Bis-Peptide Nucleic Acid”, Nucleosides, Nucleotides and Nucleic Acids, 2003, 5-8, 1023-1027.

 

Conference proceedings 

Alexander S. Wahba, Masad J. Damha and Robert H.E. Hudson† “RNA containing pyrrolocytidine base analogs: good binding affinity and fluorescence that responds to hybridization” Nucleic Acids Symposium Series 2008, 52, 399-400.

Filip Wojciechowski; Robert H.E. Hudson† “Exceptional Fluorescence and Hybridization Properties of a Phenylpyrrolocytosine in Peptide Nucleic Acid” Nucleic Acids Symposium Series, 2008, 52, 401-402.