BioIntel Paul Research Laboratory Members

Dr. Arghya Paul

Arghya Paul (Principle Investigator), is an Associate Professor in the Department of Chemical & Biochemical Engineering and Department of Chemistry at the University of Western Ontario (London, Ontario Canada). Prior to this he was an Assistant Professor at the University Of Kansas (Lawrence, USA). He did his Postdoctoral Research training with multiple Canadian scholarships in the laboratory of Prof. Ali Khademhosseini at Harvard-MIT Division of Health Sciences and Technology & Wyss Institute for Biologically Inspired Engineering (Boston, USA). He received his PhD in Biomedical Engineering with NSERC-CGSD Scholarship (Canada) at McGill University (Montreal, Canada). 

He directs the Bio-Intel Laboratory to develop new class of biofunctional nanomaterials for drug and gene delivery, regenerative tissue engineering and advanced biomedical devices for translational research. Specifically, the lab aims to: (1) innovate at the biomolecular and cellular level to develop biomedical technologies, (2) exploit the stem cell-material interactions and mechanistic pathways, and (3) discover therapeutic and diagnostic strategies which can be translated to point-of-care patient applications.

Courses Taught : 
CHEM 9608 - Polymers in Cell and Drug Delivery
CPE 656 & 756 - Introduction to Biomedical Engineering
CPE 221 - Basic Thermodynamics
PHCH 870 - Advances in Pharmaceutical Biotechnology

He believes in ......

“The best way to predict the future is to invent it” – Alan Kay

  Selected Papers

  1. Renae Waters, Siddharth Subham, Settimio Pacelli, Saman Modaresi, Aparna R Chakravarti and Arghya Paul* (2019). Development of microRNA-146a enriched stem cell secretome for wound healing applications. Molecular Pharmaceutics. DOI: 10.1021/acs.molpharmaceut.9b00639.

  2. Sayantani Basu, Settimio Pacelli, Yi Feng, Qinghua Lu, Jinxi Wang and Arghya Paul* (2018). Harnessing the Non-Covalent Interactions of DNA Backbone with 2D Silicate Nanodisks to Fabricate Injectable Therapeutic Hydrogels. ACS Nano. DOI: 10.1021/acsnano.8b02434.

  3. Ryan Maloney, Settimio Pacelli, Aparna R.Chakravarti, Jonathan Whitlow, Sayantani Basu, Saman Modaresi, Stevin Gehrke, and Arghya Paul* (2017). Controlling Adult Stem Cell Behavior Using Nanodiamond-Reinforced hydrogel: Implication in Bone Regeneration Therapy. Scientific Reports - Nature 7. Article number: 6577(2017) doi:10.1038/s41598-017-06028-y.

  4. Arghya Paul* (2015). Nanocomposite hydrogels: an emerging biomimetic platform for myocardial therapy and tissue engineering. Nanomedicine 10(9):1371-4

  5. Arghya Paul, MD Anwarul Hasan, Hamood Al-Kindi, Akhilesh Gaharwar, Mehdi Nikkhah, Mehmet Dokmeci, Dominique Shum-Tim, Ali Khademhosseini* (2014). Injectable Graphene Oxide/Hydrogel-Based Angiogenic Gene Delivery System for Vasculogenesis and Cardiac Repair. ACS Nano 8(8):8050-62

  6. Arghya Paul, Cynthia Elias, Dominique Shum-Tim, Satya Prakash* (2013). Bioactive baculovirus nanohybrids for stent based rapid vascular re-endothelialization. Scientific Reports - Nature Publisher 3:2366, doi:10.1038/srep02366.

  7. Arghya Paul, Anwarul Hasan, Laetitia Rodes, Satya Prakash* (2014). Bioengineered baculoviruses as new class of therapeutics using micro and nanotechnologies: Principles, prospects and challenges. Adv Drug Deliv Rev 71C:115-130

  8. Arghya Paul, Wei Shao, Dominique Shum-Tim, Satya Prakash* (2012). PAMAM Dendrimer-Baculovirus Nanocomplex for Microencapsulated Adipose Stem Cell-Gene Therapy: In Vitro and in Vivo Functional Assessment. ACS Molecular Pharmaceutics. 9 (9):2479-88

 Education / Research Experience

2019– Associate Professor, Canada Research Chair II,  Wolfe-Western Fellow,  Department of Chemical & Biochemical Engineering,  Department of Chemistry,   The University of Western Ontario, London, ON, Canada
2014–2019 Assistant Professor, Department of Chemical & Petroleum Engineering and Bioengineering Graduate Program, University of Kansas, Lawrence, KS, USA
Member: The Center For Epigenetics and Stem Cell Biology, Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, USA
2012–2014 Postdoctoral Research Associate, Harvard-MIT Division of Health Sciences & Technology, Cambridge, USA (Advisor: Ali Khademhosseini)
Wyss Institute for Biologically Inspired Engineering, Boston, USA
Research Topic: Advanced Tissue Engineering & NanoBiomaterials
2012– Research Fellow, Department of Cardiothoracic Research and Surgery, McGill University Health Centre, Montreal, Canada
Research Topic: Cardiovascular Therapeutics
2008–2012 PhD in Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Canada (Advisor: S Prakash, D. Shum-Tim)
Research Topic: Nano-bioengineered cardiovascular implants & devices
2006-2008 MSc (A) in Biotechnology, McGill University [in collaboration with National Research Council (NRC)-Biotech Research Inst] (Advisor: S Prakash/C Elias), Montreal, Canada
Research Topic: Nano-vectors for gene therapy and angiogenesis
2005–2006 Project Executive at R&D in IFB Industries Ltd., India
Responsibilities: Project management at bioprocess and distillery plant
2004- Undergrad Training in Biotech Operation (R&D/Process Dev), Dr. Reddy's Lab Ltd
Research Topic: Production & purification technique of proteins (summer intern)
2001-2005 Bachelor of Technology in Biotechnology, WBUT-Haldia, India
Responsibilities: Bioengineering (4 years Engineering program)

 Awards and Scholarships

2021-2026Early Researcher Award from the Ontario government
2019-2024Wolfe-Western Fellowship At-Large for Outstanding Newly Recruited Research Scholar (pan-Western)
2019-Canada Research Chair Tier 2 in Advanced Cell-Instructive Materials and Biotherapeutics, The University of Western Ontario
2018-Young Innovator Award in Cellular and Molecular Bioengineering, Biomedical Engineering Society (BMES)
2018-NIH/NIGMS NISBRE Young Investigator Travel Award
2018-Raymond Oenbring Award for Excellence in Teaching Chemical Engineering
2017-Fred Kurata Memorial Professorship at University of Kansas (till 2020)
2014- Banting Postdoctoral Fellowship awarded by Natural Sciences and Engineering Research Council (NSERC, Canada) (declined)
2013- Leslie A. Geddes Award for the Best PhD Thesis, McGill University
2012- Fonds de Recherche Sante Quebec (FRSQ) Postdoctoral award at Harvard-MIT Health Sciences and Technology & Wyss Institute for Biologically Inspired Engineering, Boston (2 years)
2012- Natural Sciences and Engineering Research Council (NSERC, Canada) Postdoctoral Award (declined) (2 years)
2012- 2 McGill MedStar Awards for best publication and research contributions
2011- McGill MedStar Award for best paper publications
2011- Canada Graduate Scholarship-Michael Smith Foreign Study Award at Harvard-MIT Health Sciences and Technology Division
2010- Alexander Graham Bell Canada Graduate Scholarship (NSERC-CGSD: 2 years)
2009- Fonds de Recherche Sante Quebec (FRSQ) Doctoral Award, Quebec, Canada (2 years)
2009- James O. Maria Meadows McGill Faculty of Medicine Internal Studentship for PhD studies (declined)
2008- McGill International Doctoral Awards

Our young scientists @Western University, Canada!

  • Aishik

    Aishik Chakraborty

    Post Doctoral Research Associate

  • Yasmeen

    Yasmeen Shamiya

    PhD in Chemistry

  • Cho-E

    Cho-E Choi

    PhD in Chemical & BioChemical Engineering

  • Alap

    Alap Zahid

    PhD in Chemical & BioChemical Engineering

  • Shruthi

    Shruthi Polla Ravi

    MESc in Biomedical Engineering

  • Ali

    Ali Coyle

    MESc in Biomedical Engineering

  • Hailey

    Hailey Adzija

    BSc in Chemistry

  • Janina

    Janina Chelu-Penalagan

    BSc in Chemistry

  • Shana

    Shana Alexander

    BESc in Chemical Engineering

  • Yousir

    Caroline Cui

    BSc in Chemistry (NSERC USRA)

  • Yousir

    Yousir Aldin

    BSc in Chemistry